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  • 1
    Electronic Resource
    Electronic Resource
    Intratumoral hypoxia resulting in the presence of a fibrotic focus is an independent predictor of early distant relapse in lymph node-negative breast cancer patients (2001)
    Oxford UK : Blackwell Science Ltd
    Histopathology 39 (2001), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Intratumoral hypoxia resulting in the presence of a fibrotic focus is an independent predictor of early distant relapse in lymph node-negative breast cancer patients Aims: To examine the importance of a fibrotic focus—a scar-like area in a carcinoma—as a marker of intratumoral hypoxia that correlates with angiogenesis and with clinical outcome in node-negative breast cancer. Methods and results: One hundred and four T1–2N0M0 breast carcinoma patients were divided into two groups: group 1 (n=46) showing early distant relapse (median disease-free survival 25 months) and group 2 (n=58) showing no evidence of disease (median follow-up 91.5 months). All tumours were evaluated for medial/lateral location, size, histological grade, mitotic activity, necrosis, fibrotic focus, angiogenesis, vascular permeation and growth pattern. Multiple regression analysis showed that only histological grade and the presence of a fibrotic focus were independent predictors of early distant relapse. A fibrotic focus was present in 53% of the tumours. The relative size (fibrotic focus/tumour ratio) was significantly correlated with an unfavourable outcome. The presence of necrosis inside the fibrotic focus and the absolute and relative size of the fibrotic focus were significantly correlated with angiogenesis. A fibrotic focus was significantly associated with large, expansively growing tumours with high histological grade and numerous mitoses. Conclusion: A fibrotic focus can be used as a surrogate for quantifying angiogenesis and is an independent predictor of early metastasis in lymph node-negative breast cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.2001.01238.x
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  • 2
    Electronic Resource
    Electronic Resource
    Cutaneous breast cancer deposits show distinct growth patterns with different degrees of angiogenesis, hypoxia and fibrin deposition (2003)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 42 (2003), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims:  We postulated that skin metastases and cutaneous local recurrences from breast adenocarcinoma show different growth patterns with distinct angiogenic profiles.Methods and results:  Fifty-one surgically resected dermal breast cancer deposits were evaluated for growth pattern, E-cadherin expression, presence of necrosis and a fibrotic focus, fibrin deposition, carbonic anhydrase IX expression (CA IX), microvessel density, endothelial cell proliferation and blood vessel immaturity. Growth patterns were infiltrative, with carcinoma cells infiltrating the dermis without significant disturbance of the pre-existing architecture, expansive, meaning that a nodule of carcinoma cells and desmoplastic tissue pushed aside the pre-existing dermal structures, or mixed. All lobular carcinomas showed an infiltrative growth and lacked membranous E-cadherin expression. Different growth patterns in the ductal carcinomas were not correlated with differences in E-cadherin expression. The presence of necrosis and/or a fibrotic focus and the expression of the hypoxia marker CA IX were significantly associated with an expansive growth. Fibrin was present in all expansive deposits and less frequently in the other growth patterns. There was a positive association between fibrin deposition, CA IX expression and microvessel density. The latter was significantly higher in the expansive and mixed growth patterns than in the infiltrative pattern. Endothelial cell proliferation was highest in the expansive growth pattern and was positively correlated with the presence of a fibrotic focus and with fibrin deposition. The maximum percentage of immature blood vessels was higher in the expansive and mixed growth patterns than in the infiltrative one.Conclusion:  The recognition of different subgroups of cutaneous breast cancer deposits with different degrees of hypoxia-driven angiogenesis may have important implications for the usefulness of anti-angiogenic therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.2003.01629.x
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  • 3
    Electronic Resource
    Electronic Resource
    Lack of angiogenesis in lymph node metastases of carcinomas is growth pattern-dependent (2002)
    Oxford UK : Blackwell Science Ltd
    Histopathology 40 (2002), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.2002.1340c.x
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  • 4
    Electronic Resource
    Electronic Resource
    Development of a special anti-Compton spectrometer
    Amsterdam : Elsevier
    Nuclear Inst. and Methods in Physics Research, B 64 (1992), S. 282-286 
    Details
    ISSN: 0168-583X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0168-583X(92)95481-6
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  • 5
    Electronic Resource
    Electronic Resource
    The least-squares discriminant function
    Amsterdam : Elsevier
    Optics Communications 89 (1992), S. 73-79 
    Details
    ISSN: 0030-4018
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0030-4018(92)90251-L
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  • 6
    Electronic Resource
    Electronic Resource
    Scaling of CGHs with hologram size
    Amsterdam : Elsevier
    Optics Communications 78 (1990), S. 25-29 
    Details
    ISSN: 0030-4018
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0030-4018(90)90051-T
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  • 7
    Electronic Resource
    Electronic Resource
    The influence of a pneumoperitoneum on the peritoneal implantation of free intraperitoneal colon cancer cells (1996)
    Springer
    Surgical endoscopy and other interventional techniques 10 (1996), S. 809-812 
    Details
    ISSN: 1432-2218
    Keywords: Pneumoperitoneum ; Tumor seeding ; Portsite metastases ; Implantation ; Abdominal-wall metastases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: In order to test the influence of a pneumoperitoneum on the peritoneal implantation of free intraperitoneal colon cancer cells, 40 male syngeneic WAG rats were at random divided into four groups. Methods: Group 1 (n=10) animals underwent a midline laparotomy and 104 CC531 colon cancer cells were injected intraperitoneally (IP); in group 2 (n=10) 104 CC531 cells were injected IP without further manipulation; in group 3 (n=10) a pneumoperitoneum up to 10 mmHg was created after the IP injection of the same amount of CC531 cells. The pneumoperitoneum was maintained for 15 min. Finally in group 4 (n=10) after the IP injection of 104 CC531 cells and after the creation of a pneumoperitoneum, two 14-G IV catheters simulating trocars were introduced in each flank. A follow-up period of 8 weeks was used. Tumor implantation was scored according to the peritoneal cancer index of Eggermont and the index of Chauffert. Results: Tumor nodules were found varying from 60% in groups 1–3 to 50% in group 4. There was no statistical difference between the implantation rate in the four groups. A port-site recurrence was seen in group 4; all the other tumor implants were located in the mesenterium, omentum, internal genitals, or parietal peritoneum. Conclusions: The presence of a pneumoperitoneum does not enhance the implantation of free intraperitoneal malignant colon cancer cells in the rat, but the presence of a “port” may lead to abdominal-wall metastases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00189539
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  • 8
    Electronic Resource
    Electronic Resource
    The influence of a pneumoperitoneum on the peritoneal implantation of free intraperitoneal colon cancer cells (1996)
    Springer
    Surgical endoscopy and other interventional techniques 10 (1996), S. 809-812 
    Details
    ISSN: 1432-2218
    Keywords: Key words: Pneumoperitoneum — Tumor seeding — Port-site metastases — Implantation — Abdominal-wall metastases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: In order to test the influence of a pneumoperitoneum on the peritoneal implantation of free intraperitoneal colon cancer cells, 40 male syngeneic WAG rats were at random divided into four groups. Methods: Group 1 (n= 10) animals underwent a midline laparotomy and 104 CC531 colon cancer cells were injected intraperitoneally (IP); in group 2 (n= 10) 104 CC531 cells were injected IP without further manipulation; in group 3 (n= 10) a pneumoperitoneum up to 10 mmHg was created after the IP injection of the same amount of CC531 cells. The pneumoperitoneum was maintained for 15 min. Finally in group 4 (n= 10) after the IP injection of 104 CC531 cells and after the creation of a pneumoperitoneum, two 14-G IV catheters simulating trocars were introduced in each flank. A follow-up period of 8 weeks was used. Tumor implantation was scored according to the peritoneal cancer index of Eggermont and the index of Chauffert. Results: Tumor nodules were found varying from 60% in groups 1–3 to 50% in group 4. There was no statistical difference between the implantation rate in the four groups. A port-site recurrence was seen in group 4; all the other tumor implants were located in the mesenterium, omentum, internal genitals, or parietal peritoneum. Conclusions: The presence of a pneumoperitoneum does not enhance the implantation of free intraperitoneal malignant colon cancer cells in the rat, but the presence of a ``port'' may lead to abdominal-wall metastases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004649900166
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  • 9
    Electronic Resource
    Electronic Resource
    Production, disinfection and evaluation for aquaculture applications of rotifer resting eggs from Bohai Bay, P.R. of China (1997)
    Springer
    Aquaculture international 5 (1997), S. 0-0 
    Details
    ISSN: 1573-143X
    Keywords: Brachionus plicatilis ; Disinfection ; Resting egg production ; Rotifers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract The dynamics of resting egg production of the rotifer Brachionus plicatilis originating from a wild population in the Tanggu Saltworks (P.R. China) was investigated. In the natural environment as well as in semi-controlled rearing conditions an increased resting egg production was noticed with declining food availability. Processed resting eggs had a hatching efficiency of 3 x 10 6 rotifers per gramme irrespective of their origin. Hatching started 22 h after the initiation of incubation and was completed after 36 h. Rotifers obtained from resting eggs could be further cultured on Culture Selco® and enriched with Super Selco®. The fatty acid profile of these rotifers were not divergent from reference rotifers (originating from the Laboratory of Aquaculture and Artemia Reference Centre) demonstrating that this strain was not catabolizing essential fatty acids and could be used for enrichment purposes. Storage of resting eggs at 4°C resulted in a 50% lower hatching after 1 year but remained stable during the next 2 years. The resting eggs used for storage could easily be disinfected without affecting their hatching characteristics. These results indicate that this material could be used as inocula for mass cultures of live food for commercial hatcheries.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018331200146
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