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  • 1
    Electronic Resource
    Electronic Resource
    Separation of 2,4-Dinitrophenylhydrazones of Some Substituted Benzaldehydes by Chromatographic Adsorption (1952)
    s.l. : American Chemical Society
    Analytical chemistry 24 (1952), S. 412-413 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60062a041
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  • 2
    Electronic Resource
    Electronic Resource
    Monoamine oxidase activities in human brain microvessels (1981)
    Springer
    Cellular and molecular life sciences 37 (1981), S. 764-765 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Microvessels can be easily isolated from human brain samples obtained at autopsy. Human frontal cortex MAO type A and B activities are similar in microvessel and microvessel-free preparations. In microvessels, enzyme activities and the ratio of MAO type A to type B vary among the areas studied and could selectively regulate the passage of certain amines through the blood vessel wall.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01967968
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  • 3
    Electronic Resource
    Electronic Resource
    Experimentelle und immunologische Untersuchungen der biologischen Wirkung von Hormonen (1968)
    Springer
    Journal of molecular medicine 46 (1968), S. 557-560 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In using the mixed-agglutination technique, the application of sheep-antisera to testosterone-3-bovine serum albumin to seminal vesicles of normal fertile rats and castrated rats after reenlargement of their atrophied seminal vesicles by means of an administration of testosterone, revealed evidence of a localization of testosterone in the epithelial cells of these seminal vesicles. Testosterone could not be detected in the seminal secretion fluid (seminal plasma). Results from control experiments confirm these findings.
    Notes: Zusammenfassung Schafantiseren gegen ein Testosteron-3-Rinderserumalbumin-Konjugat ergaben bei der Mixed-Agglutination Anhaltspunkte für eine Lokalisation von Testosteron im Samenblasenepithel von normalen geschlechtsreifen Ratten und solchen kastrierten Ratten, bei denen eine Kastrationsatrophie der Samenblasen durch Testosterongaben aufgehoben wurde. Es konnten keine Beweise einer Anwesenheit von Testosteron im Samenblasensekret erbracht werden. Resultate von endokrinologischen und serologischen Kontrollexperimenten erhärteten die erhobenen Befunde.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01747777
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  • 4
    Electronic Resource
    Electronic Resource
    Bromcarbamidvergiftung, ein Modell der Schocklunge (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 467-470 
    Details
    ISSN: 1432-1440
    Keywords: Bromcarbamide ; intoxication ; microthrombosis of the lung ; shock — lung — syndrome ; Bromcarbamidvergiftung ; Mikrothrombosierung der Lunge ; Schocklunge
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An drei Patienten, die an Bromcarbamid-Vergiftung verstarben und 18 Kaninchen, denen dieses Hypnotikum per os verabreicht wurde, konnten gleichlautende Befunde erhoben werden: Thrombocytenaggregationen mit Verlegung der Lungenstrombahn, Mikroembolismus, Endotheldefekte, perivasculäres Ödem und Lymphbahndilatation. Die Lungen waren von der Mikrothrombosierung besonders betroffen. Die Verlegung der Lungenstrombahn und die Permeabilitätsstörungen in der Lunge wirkten sich klinisch in einer Verminderung der Sauerstoffaufnahme und Erhöhung der Drucke im rechten Herzventrikel und in der Arteria pulmonalis aus. Die dargelegten Befunde bei Bromcarbamidvergiftung gleichen denjenigen beim Schocklungen-syndrom, wobei auch hier die Mikrothrombosierung im Mittelpunkt des pathologischen Geschehens steht. Beide Modelle können nutzbringend zum gegenseitigen weiteren Verständnis angewandt werden.
    Notes: Summary Bromcarbamide-intoxication in three patients and 18 rabbits has been analysed. The patients died from the overdose, rabbits received the drug per os and died spontaneously or else they survived and were killed. In patients and in experimental studies identical results could be obtained: the initiating event seems to be the aggregation of thrombocytes and obstruction of the pulmonary vascular bed. Apparently, the thrombi circulate as could be demonstrated with intravital microscopy. Simultaneously endothelial defects, perivascular edema and dilatation of the lymphatics appear. The obstruction of the pulmonary vascular bed and the enhancement of permeability in the lung had a depressory effect on oxygen-uptake. Blood pressure raised in both the right ventricle and arteria pulmonalis. The results with bromcarbamide-poisoning are equivalent to findings in the shock lung syndrome, where microthrombosis plays a central role in the pathophysiological process. Both models can be usefully applied for the mutual understanding of the underlying pathogenic mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01487602
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  • 5
    Electronic Resource
    Electronic Resource
    Über den Gestaltwandel des Schocksyndroms innerhalb zweier Jahrzehnte (1973)
    Springer
    Journal of molecular medicine 51 (1973), S. 37-38 
    Details
    ISSN: 1432-1440
    Keywords: Shock syndrome ; pathomorphosis ; changes in disease patterns ; therapy of shock ; consumptive coagulopathy ; Schocksyndrom ; Gestaltwandel ; Pathomorphose ; Schocktherapie ; Verbrauchskoagulopathie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Von 1949–1971 hat sich der Ablauf und die Gestalt des Schocksyndroms stark gewandelt. Die Pathomorphose ist bedingt durch Verlängerung der Krankheitsdauer (von 4 auf 11 Tage), Hinzufügung neuer Stadien (1. Periode: Hypovolämie-Volumensubstitution; 2. Periode: Nierenversagen-Dialyse; 3. Periode: respiratorische Insuffizienz-Schocklungen) und positive und negative Folgen der Therapie (Überwässerung, O2-Toxizität). Eine Änderung der ärztlichen Anschauung hat zudem einen scheinbaren Gestaltwandel des Schocksyndroms herbeigeführt. Besonders die Einführung des Konzeptes der Verbrauchskoagulopathie, Erkennung morphologischer Äquivalente des Schocks und eine perfektionierte Kriegsmedizin haben den Blickwinkel verschoben.
    Notes: Summary The shock syndrome has undergone great changes both in aspect and pattern (pathomorphosis) during the last 20 years. Between 1949 and 1971, the survival time of patients has increased from 4 to 11 days. This has produced the appearance of new stages in the shock syndrome: 1st period: hypovolaemia with fluid replenishment; 2nd period: acute renal failure with dialysis; and 3rd period: respiratory insufficiency with respirator therapy. Longer survival produces both positive and negative therapeutical consequences (liquid overload, O2-toxicity). In addition, changes in medical approach toward the shock syndrome have brought about an apparent change in the form of the afflication. Refined clinical methods, the introduction of the concept of consumptive coagulopathy, the knowledge of morphological equivalents of shock and perfect war-time medicine have changed views and judgements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01484141
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  • 6
    Electronic Resource
    Electronic Resource
    Einfluß einer adjuvanten Immunglobulintherapie auf Infektionen bei Patienten einer operativen Intensiv-Therapie-Station (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 245-256 
    Details
    ISSN: 1432-1440
    Keywords: Immunoglobulin therapy ; Severe infections ; Intensive care patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A randomized controlled clinical trial was conducted on the effects of immunoglobulin in therapy for infections in 104 intensive care patients. At the first sign of infection, one group of 50 patients received an i.v. preparation of immunoglobulin (4×100 ml) combined with antibiotics. The other 54 control patients received antibiotics alone. The most common infections in these patients were pneumonia, septicemia, peritonitis and wound sepsis. Infections were significantly seldom the cause of death, especially in patients with high-risk surgery who had been treated with immunoglobulin (p≤0.05). Likewise ventilation time in the high-risk surgery group averaged only 5.5 days for those receiving immunoglobulin as opposed to 12.7 days in controls (p≤0.01). Whereas the control group, in particular patients with pneumonia, remained in intensive care an average of 21.5 days, those receiving immunoglobulin stayed only 14.8 days (p≤0.01). In general, patients treated with immunoglobulin recovered more rapidly from infections than did controls (p≤0.01).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01711930
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  • 7
    Electronic Resource
    Electronic Resource
    Occupancy of the iron-binding sites of human transferrin in sera obtained from different anatomical sites (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 538-542 
    Details
    ISSN: 1432-1440
    Keywords: Iron-binding site ; Transferrin ; Tissue iron exchange ; Organ donors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Transferrin is the major iron-transport protein in serum. Four molecular species (apo-, two mono-, and diferric transferrins) can be distinguished on the basis of their occupancy with iron. These species differ physicochemically and in the affinity with which they bind to the transferrin receptor. To elucidate the possible role of the four molecular species in directing the flow of iron between the major anatomical sites of iron release and utilization we have analyzed sera from eight stable multiorgan donors. The samples were obtained from veins draining the spleen, gut, and liver, and from the periphery. Employing polyacrylamide-gel electrophoresis in combination with crossed immunoelectrophoresis we were able to identify the four molecular species in all samples. Apo-transferrin was the predominant molecular species while differric transferrin was the least abundant (P〈0.01). The monoferric species were dominated by the acid-stable form (iron loading on the C-terminal end of the molecule) with ratios C/N from 1.2 (splenic and posthepatic serum) to 1.5–1.6 in mesenteric or peripheral samples respectively. We conclude from our study that it is unlikely that the monoferric transferrin species play a role in directing internal iron exchange and that in accordance with most of the literature the acidstable form is preferentially loaded under physiological conditions of iron metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01719780
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  • 8
    Electronic Resource
    Electronic Resource
    Single-Channel Analysis of a Delayed Rectifier K+ Channel in Xenopus Myelinated Nerve (1996)
    Springer
    The journal of membrane biology 149 (1996), S. 221-232 
    Details
    ISSN: 1432-1424
    Keywords: Key words: Patch clamp — Myelinated nerve fiber — Potassium channel — Single Channel — Resting potential
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract. Single-channel properties of a delayed rectifier voltage-gated K+ channel (I-type) were investigated in peripheral myelinated axons from Xenopus laevis. Channels activated between −60 and −40 mV with a potential of half-maximal activation, E50, at −47.5 mV. Averaged single-channel currents activated with a time delay at all membrane potentials tested. Time to half-maximal activation decreased from 80 to 1.6 msec between −60 and +40 mV. The channel inactivated monoexponentially with a time constant of 10.9 sec at −40 mV. The time constant of deactivation was 126 msec at −80 mV and 16.9 msec at −110 mV. In symmetrical 105 mm K+, the single-channel conductance (γ) was 22 and 13 pS at negative and positive membrane potentials, respectively, at 13–15°C. In Na+-rich solution with 2.5 mm extracellular K+γ was 7 pS and the reversal potential was negative to −80 mV, indicating a high selectivity for K+ over Na+. γ depended on extracellular K+ concentration (K D = 19.6 mm) and temperature (Q 10= 1.45). External tetraethylammonium (TEA) reduced the apparent single-channel current amplitude at all potentials tested with a half-maximal inhibiting concentration (IC50) of 0.6 mm. Open probability of the channel, but not single-channel current amplitude was decreased by extracellular dendrotoxin (DTX, IC50= 6.8 nm) and mast cell degranulating peptide (MCDP, IC50= 41.9 nm). In Ringer solution the membrane potential of macroscopic I-channel patches was about −65 mV and depolarized under TEA and DTX. It is concluded that besides their activation during action potentials, I-channels may also stabilize the resting membrane potential.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002329900022
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  • 9
    Electronic Resource
    Electronic Resource
    Large Conductance Ca2+-activated K+ Channels in the Soma of Rat Motoneurones (1998)
    Springer
    The journal of membrane biology 162 (1998), S. 9-15 
    Details
    ISSN: 1432-1424
    Keywords: Key words: Potassium channel — Motoneurone — Spinal cord — Slice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract. Properties of large conductance Ca2+-activated K+ channels were studied in the soma of motoneurones visually identified in thin slices of neonatal rat spinal cord. The channels had a conductance of 82 ± 5 pS in external Ringer solution (5.6 mm K+ o //155 mm K+ i ) and 231 ± 4 pS in external high-K o solution (155 mm K+ o //155 mm K+ i ). The channels were activated by depolarization and by an increase in internal Ca2+ concentration. Potentials of half-maximum channel activation (E50) were −13, −34, −64 and −85 mV in the presence of 10−6, 10−5, 10−4 and 10−3 m internal Ca2+, respectively. Using an internal solution containing 10−4 m Ca2+, averaged KCa currents showed fast activation within 2–3 msec after a voltage step to +50 mV. Averaged KCa currents did not inactivate during 400 msec voltage pulses. External TEA reduced the apparent single-channel amplitude with a 50% blocking concentration (IC50) of 0.17 ± 0.02 mm. KCa channels were completely suppressed by externally applied 100 mm charybdotoxin. It is concluded that KCa channels activated by Ca2+ entry during the action potential play an important role in the excitability of motoneurones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002329900337
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  • 10
    Electronic Resource
    Electronic Resource
    Tandemchromosom (G/G) mit Satelliten am kurzen und langen Arm bei einem Patienten mit Translokationstrisomie G1 (1970)
    Springer
    Human genetics 〈Berlin〉 9 (1970), S. 361-371 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Wir berichten über einen Patienten mit dem Vollbild des Down-Syndroms und spontaner Translokationstrisomie G1. Das Translokationschromosom ist aus einer Tandemfusion zwischen zwei G-Chromosomen hervorgegangen und trägt Satelliten am kurzen und langen Arm. Es kann auch autoradiographisch nicht entschieden werden, welche G-Chromosomen an der Translokation beteiligt sind. Aus der Literatur bekannte G/G-Tandemfusionen werden mit unserem Fall verglichen und mögliche Entstehungsmechanismen des Tandemchromosoms diskutiert.
    Notes: Summary Report on a patient with features characteristic of Down's syndrome, trisomic for a G-group chromosome due to G/G translocation. The acrocentric translocation chromosome is assumed to be the product of a tandem-fusion event and is endowed with satellites on both short and long arm. The identification of the G-chromosomes involved in this translocation could not be achieved by means of autoradiography. Discussion bears on possible mechanisms leading to the formation of the tandem-chromosome (with additional long arm satellites). Reports of similiar published cases are revised.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00286998
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