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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Der Hautarzt 50 (1999), S. 5-11 
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Melatonin (N-Acetyl-5-Methoxytryptamin) ; Zirkadianer Rhythmus ; Schlaf-Wach-Rhythmus ; Radikalfänger ; Key words Melatonin (N-acethyl-5-methoxytryptamin) ; Circadian rhythm ; Daily sleep induction ; ageing ; Free radical scavenger
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Melatonin (N-acetyl-5-methoxytryptamine) is a hormone with multiple functions in humans, produced by the pineal gland and stimulated by β-adrenergic receptors. Serum melatonin levels exhibit a circadian rhythm with low levels during the day, rise in the evening and maximum levels at night between 2 and 4 a.m.. Melatonin participates in the regulation of several physiological processes such as seasonal biological rhythm, daily sleep induction, aging and modulation of immunobiological defence reactions. Furthermore, melatonin has a highly lipophilic molecular structure facilitating penetration of cell membranes and serving as an extra- and intracellular free radical scavenger. Melatonin seems to quench mainly hydroxyl radicals, the most damaging of all free radicals. Melatonin may play a role in the etiology and treatment of several dermatoses e.g. atopic eczema, psoriasis and malignant melanoma. The influence of melatonin on hair growth is another aspect. Topical application of melatonin inhibits the development of UV-erythema. Penetration through skin after topical application and oral bioavailability auxit further investigations on the pharmacokinetic and pharmacodynamic actions of melatonin.
    Notes: Zusammenfassung Melatonin (N-Acetyl-5-Methoxytryptamin) ist ein unter dem Einflußβ-adrenerger Rezeptoren von der Glandula pinealis produziertes und sezerniertes Hormon mit vielfältigem Wirkungsspektrum. Die Ausschüttung des Hormons folgt einem zirkadianen Rhythmus mit niedrigen, gleichmäßigen Spiegeln tagsüber und einem abendlichen Ansteigen und nächtlichen Peak zwischen 2.00 und 4.00 Uhr. Melatonin beeinflußt den saisonalen Biorhythmus, den Schlaf-Wach-Rhythmus, den Alterungsprozeß und moduliert immunbiologische Abwehrfunktionen. Zusätzlich besitzt Melatonin unabhängig von einem Rezeptorsystem durch seine starken lipophilen Eigenschaften die Fähigkeit, frei durch Zellmembranen zu diffundieren und im extra- wie intrazellulären Raum als Radikalfänger zu wirken. Die Affinität zu dem stark schädigenden Hydroxylradikal ist besonders groß. In der Dermatologie ergeben sich für Melatonin Perspektiven bei einigen Hauterkrankungen wie zum Beispiel dem atopischen Ekzem, der Psoriasis und dem malignen Melanom. Der Einfluß von Melatonin auf das Haarwachstum ist ein weiterer Aspekt. In topischer Anwendung hat Melatonin eine suppressive Wirkung auf die Ausbildung eines UV-Erythems. Über die Penetrationseigenschaften durch die Haut und die orale Verfügbarkeit liegen einige Erkenntnisse vor, die durch weitere Untersuchungen der Pharmakokinetik und Pharmakodynamik ergänzt werden können.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK; Malden, USA : Munksgaard International Publishers
    Contact dermatitis 53 (2005), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The objective of this study is to determine the effect of emollients in a propanol-based hand rub on skin dryness and erythema. In this prospective, randomized, controlled, double-blind trial, 35 subjects participated; of them approximately half were atopic (modified Erlanger atopy score ≥8). 2 propanol-based formulations were tested in a repeated open application test, 1 contained a mixture of emollients (0.81%, w/w). 2 aliquots of 0.7 ml of each formulation were applied twice per day over 2 weeks to the cubital fossa of each subject after random assignment of the preparations. Treatment areas were assessed before each application and 3 days postfinal application by visual inspection for erythema and dryness according to a standard scale. The sum score over all assessment time-points served as primary parameter. The mean sum score for erythema and dryness was significantly lower for the hand rub with emollients (0.8 ± 2.4) in comparison with that for the hand rub without emollients (1.5 ± 3.5; P = 0.022; Wilcoxon signed rank test). A comparison of the atopic and non-atopic subjects revealed no significant difference for any of the products (P 〉 0.05; Mann–Whitney U-test). It is concluded that the addition of emollients to a propanol-based hand rub can significantly decrease irritant contact dermatitis under frequent-use conditions.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 41 (1999), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Products intended for individuals in contact with strongly adhering dirt often contain grit. Various clinical test methods have been developed for evaluating the potential of personal washing products to induce skin irritation. In the present study, differences in the irritant effects of washing products containing naturally-derived grit and synthetic grit were investigated in a forearm wash test. The forearms of 16 test subjects were washed in a total of 18 treatments (4 per day for 4 days, with 2 treatments on the 5th day). Treatment consisted of continuous washing for 2 min by a technician, who gently slid his fingertips with the lather up and down the forearm. Non-invasive instrumental measurements of skin barrier function were performed. Repetitive washing for 1 week lead to increased TEWL values, skin redness and decreased stratum corneum hydration. Results indicate differences in irritancy potential due to different types of grit, their surface and concentration. It is concluded that the repeated wash test seems to be adequate for rating personal washing products that contain grit.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Wood-Licht ; Fluoreszenz ; Applikation ; Prävention ; Hautschutz ; Key words Wood’s light ; Fluorescence ; Application ; Prevention ; Skin protection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The invisible long-wave ultraviolet radiation (340–450 nm, max. 365 nm) produced by a Wood lamp can help to diagnose dermatoses with a characteristic fluorescence (tinea capitis, erythrasma, tinea versicolor, Pseudomonas infections, porphyrians, and pigmentary alterations). It is also used in the detection of medications that are taken systemcally (tetracycline) or that are applied to the skin. Recently, a fluorescence technique with Wood light has been used as a preventive measure to monitor and quantify skin protection at the workplace and to teach workers in high-risk occupations the proper use of protective creams.
    Notes: Zusammenfassung Das durch eine Wood-Lampe emittierte langwellige UV A-Licht (340–450 nm, Max. 365 nm) wird vor allem in der Diagnostik von Dermatosen, die mit einer typischen Fluoreszenz einhergehen (Tinea capitis, Erythrasma, Tinea versicolor, Pseudomonas aeruginosa-Infektionen, Porphyrien und Pigmentveränderungen), eingesetzt. Neben dem Nachweis systemisch verabreichter Medikamente (Tetracyclin) ist die Fluoreszenz unter Wood-Licht durch Zusatz von Fluoreszenzmarkern in der Applikationskontrolle von Topika angewendet worden. Neu ist die Verwendung von Fluoreszenztechniken als Bestandteil präventiver Maßnahmen in der Anwendungskontrolle von Hautschutzpräparaten und in der Schulung hautgefährdeter Beschäftigter.
    Type of Medium: Electronic Resource
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