Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    [3H]SCH 23390 Binding to Human Putamen D-1 Dopamine Receptors: Stereochemical and Structure-Affinity Relationships Among l-Phenyl-1H-3-Benzazepine Derivatives as a Guide to D-l Receptor Topography (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 48 (1987), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: A series of l-phenyl-1H-3-benzazepine analogues were assessed for enantiomeric and structure-affinity relationships at human putamen D-1 dopamine receptors labelled with [3H]SCH 23390. Substitution at the 7-position of both 3-H and 3-methyl benzazepine molecules critically affected affinity for these receptors over a 500-fold range. The general rank order of potency of 7-substituents was Cl = Br ≫ CH3 〉 OH ≥ H. 3-Methyl substituents increased the affinity of 7-H and 7-OH compounds two- to fivefold compared to desmethyl counterparts. The displacement of [3H]SCH 23390 binding showed substantial enantioselec-tivity; the R-enantiomer of SKF 83566 was 500-fold more potent that its S-antipode. However, the displacement of [3H]spiperone binding from D-2 sites in the same tissue showed negligible enantioselectivity. Through such structure-affinity relationships, these studies may help to define the topography of the human brain D-1 dopamine receptor and guide the design of more selecive agents for functional studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1987.tb05623.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Substantia Nigra γ-Aminobutyric Acid Receptors in Huntington's Disease (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 37 (1981), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The specific binding of [3H]γ-aminobutyric acid (GABA) to nigral GABA receptors has been studied in postmortem brains from controls and patients with Huntington's disease (HD). A specific increase in the number of high-affinity binding sites for [3H]GABA was observed in HD patients, analogous to changes observed in rat substantia nigra [3H]GABA binding after striatal kainic acid (KA) lesion. The results provide further support for the striatal KA lesion in the rat as an animal model of HD. The implications of the results for the proposed therapeutic potential of GABA agonists in HD are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1981.tb00458.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    GABAergic mechanisms in the substantia nigra (1980)
    [s.l.] : Nature Publishing Group
    Nature 283 (1980), S. 696-697 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] MARTIN AND HAUBRiCH1 have confirmed the original reports2,3 of contralateral rotational behaviour following unilateral injections of the ?-aminobutyric acid (GABA) agonist muscimol into the zona reticulata of the rat substantia nigra. They have also confirmed a previous report4 that intrani-gral ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/283696a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Denervation supersensitivity in the striatonigral GABA pathway (1978)
    [s.l.] : Nature Publishing Group
    Nature 276 (1978), S. 618-620 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 Left: rotational responses in automated rotometers20 1 h after unilateral intranigral injection of muscimol (2 ng; stereotaxic coordinates: A2.2, V-2.8, L2.0, Konig & Klippel ) made 3 weeks after ipsilateral striatal KA lesions (2.5 mg; coordinates A8.0, V0.0, L2.5) or in unlesioned ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/276618a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Further evidence for two directions of D-1:D-2 dopamine receptor interaction revealed concurrently in distinct elements of typical and atypical behaviour: studies with the new enantioselective D-2 agonist LY 163502 (1989)
    Springer
    Psychopharmacology 98 (1989), S. 245-250 
    Details
    ISSN: 1432-2072
    Keywords: LY 163502 ; Dopamine D-1 and D-2 receptors ; Jerking ; Behavioural assessment ; Stereotypy ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The new, extremely potent and enantioselective D-2 agonist LY 163502 failed to induce compulsive stereotyped behaviour. Very low doses (3–6 μg/kg) inhibited spontaneous sniffing and locomotion, while higher doses (12–50 μg/kg) induced episodes of non-stereotyped sniffing and chewing; these actions showed complete enantioselectivity. Up to 200-fold higher doses modestly induced only locomotion. Responsivity to LY 163502 was enantioselectively blocked by the selective D-2 antagonist R-piquindone. This responsivity was also enantioselectively blocked by the selective D-1 antagonist R-SK&F 83566 but, additionally, episodes of atypical limb/body jerking behaviour were released; thus, LY 163502 induced such jerking only when tonic D-1 activity was suppressed. These data extend our notion that there may be at least two forms of functional interaction between D-1 and D-2 receptor systems: one cooperative, as in the regulation of typical sniffing, and another oppositional, as in the regulation of atypical jerking.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00444699
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Rotational behaviour and cGMP responses following manipulation of nigral mechanisms with chlordiazepoxide (1977)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 300 (1977), S. 233-237 
    Details
    ISSN: 1432-1912
    Keywords: Benzodiazepines ; GABA ; Rotation ; cGMP ; Substantia nigra
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Unilateral stereotaxic injections of 1 μg of the soluble benzodiazepine chlordiazepoxide hydrochloride into the predominantly GABA-containing zona reticulata of the substantia nigra of amphetamine-pretreated rats induced rotational behaviour similar to that seen following unilateral elevation of nigral GABA levels and amphetamine treatment; this effect was not seen following injections into the vicinity of the predominantly dopamine-containing zona compacta. Chlordiazepoxide-induced rotations were abolished by the GABA-antagonist picrotoxin. Both chlordiazepoxide and GABA depressed production of cyclic 3′,5′-guanosine monophosphate in samples of nigral tissue in vitro as estimated by radioimmunoassay. It is concluded that chlordiazepoxide may enhance GABA transmission within the substantia nigra, by some as yet unidentified mechanism, to create asymmetric activity in GABA-modulated neurones and hence induce rotation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500965
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Baclofen and muscimol: Behavioural and neurochemical sequelae of unilateral intranigral administration and effects on 3H-GABA receptor binding (1979)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 306 (1979), S. 275-280 
    Details
    ISSN: 1432-1912
    Keywords: Baclofen ; Muscimol ; GABA ; Rotational behaviour ; 3H-GABA binding ; Substantia nigra
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Log dose-response curves for induction of contralateral rotational behaviour in the rat by unilateral intranigral injections of the GABA agonist muscimol and the GABA analogue baclofen have been compared. Baclofen, 5–1000 ng, produced a maximal rotational response that was only 40% of that produced by 0.25–100 ng muscimol, and log dose-response curves failed to show parallelism. The behavioural effects of both drugs were only weakly antagonised by haloperidol and were not antagonised by 6-hydroxydopamine lesions of ipsilateral dopamine (DA) neurons, indicating that these responses were independent of DAergic mechanisms. The effects of baclofen were weakly antagonised by picrotoxin. Intranigral muscimol and baclofen substantially elevated striatal DA concentrations. While muscimol also substantially elevated striatal dihydroxyphenylacetic acid (DOPAC) but not homovanillic acid (HVA), baclofen did not significantly effect either DOPAC or HVA. Baclofen, GABA and muscimol displaced specific 3H-GABA binding in vitro with IC50's of 40 μm 400 nM and 40 nM respectively. These results indicate that muscimol and baclofen do not act via a unitary GABAergic mechanism, but suggest that baclofen may be a partial GABA agonist, at least at nigral GABA receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00507114
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Dissociation of the anti-punishment activities of chlordiazepoxide and atropine using two heterogeneous passive avoidance tasks (1977)
    Springer
    Psychopharmacology 52 (1977), S. 93-96 
    Details
    ISSN: 1432-2072
    Keywords: Passive avoidance ; Punishment ; Escape ; Chlordiazepoxide ; Atropine ; Disinhibition ; Benzodiazepines ; Anticholinergics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of chlordiazepoxide and atropine on the acquisition of passive avoidance learning in rats were compared in two superficially similar but theoretically distinct forms of the step down task in an attempt to dissociate behaviourally the disinhibiting effects of these two classes of drug. In a discrete trial procedure both chlordiazepoxide and atropine significantly retarded acquistion; on retention testing under saline treatment alone, the initial chlordiazepoxide group showed no change in behaviour while the initial atropine group showed a facilitation. In a continuous trial procedure, however, atropine but not chlordiazepoxide produced an increase in the total number of step downs; despite this, these groups showed acquisition at similar rates, though learning was not shown on retention testing under saline alone. These results enabled the two classes of drug to be distinguished. The nature of the heterogeneity between the two test paradigms is discussed, and results interpreted in terms of possible differential drug effects on punishment and escape components of the tasks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426606
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Methodological problems in the measurement of drug-induced rotational behaviour: Continuous recording reveals time-course differences undetected by previous techniques (1978)
    Springer
    Psychopharmacology 58 (1978), S. 153-155 
    Details
    ISSN: 1432-2072
    Keywords: Rotational behaviour ; 6-Hydroxydopamine ; 5,6-Dihydroxytryptamine ; Assessment techniques
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats were lesioned unilaterally in the medial forebrain bundle with either the catecholamine neurotoxin 6-hydroxydopamine or the indoleamine neurotoxin 5,6-dihydroxytryptamine. Their rotational responses in automated rotameters to a challenge with the dopamine-receptor agonist apomorphine were compared using four different techniques in current use, and by assessment of complete rotation curves using both conventional statistical procedures and elementary computer-derived elements of curvature. The rotational responses of the two groups, characterized neurochemically by identical depletions of striatal dopamine but with a greater depletion of striatal 5-hydroxytryptamine in 5,6-dihydroxytryptamine-lesioned animals, were indistinguishable using each of the four current techniques. Assessment of rotation curves by both methods revealed significant differences between the two groups, characterised by faster onset and offset of the rotational response in 5,6-dihydroxytryptamine-lesioned animals. Some current techniques may implicitly exclude the detection of such time-course differences in rotational behaviour. Assessment of complete rotation curves may best allow valid comparisons between experimental groups.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426898
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Dopaminergic behaviour stereospecifically promoted by the D1 agonist R-SK & F 38393 and selectively blocked by the D1 antagonist SCH 23390 (1984)
    Springer
    Psychopharmacology 82 (1984), S. 409-410 
    Details
    ISSN: 1432-2072
    Keywords: Dopamine D1 & D2 receptors ; SK & F 38393 ; SCH 23390 ; Grooming ; Behaviour ; Stereotypy ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The selective D1 dopamine receptor agonist R-SK & F 38393 (20 mg/kg), but not its S-antipode, stereospecifically promoted episodes of prominent grooming behaviour. Typical stereotyped behaviour, such at that induced by apomorphine, was not seen. Grooming responses to 20 mg/kg R-SK & F 38393 were blocked by 0.1–0.5 mg/kg of the selective D1 antagonist SCH 23390 but not by 1.0–5.0 mg/kg of the selective D2 antagonist metoclopramide, while stereotyped behaviour induced by 0.5 mg/kg apomorphine was blocked by both antagonists. These results are consistent with certain individual dopaminergic behaviours such as grooming being mediated by D1 receptors. Other dopaminergic syndromes may involve complex functional interactions between D1 and D2 receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427697
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...