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  • 1
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Nekrolytisches migratorisches Erythem ; Paraneoplasie ; Plattenepithelkarzinom ; Glukagonom ; Key words Necrolytic migratory erythema ; Paraneoplasia ; Squamous cell carcinoma ; Glucagonoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A 59-year-old Caucasian man suffered from persistent disseminated necrolytic skin lesions for 8 months. They failed to respond to a variety of therapeutic regimens but then cleared spontaneously within a few days. After one week an invasive squamous cell carcinoma of the hypopharynx became clinically apparent. At autopsy, the expected glucagonoma often associated with necrolytic migratory erythema was not found.
    Notes: Zusammenfassung Nach achtmonatiger therapierefraktärer Persistenz disseminierter nekrolytischer Hautveränderungen kam es bei einem 59jährigen Patienten zu einer spontanen Abheilung der Läsionen innerhalb weniger Tage. Eine Woche später manifestierte sich klinisch ein invasiv wachsendes Plattenepithelkarzinom des Hypopharynx. Ein im Rahmen der kutanen Paraneoplasie zu erwartendes Glukagonom konnte autoptisch nicht nachgewiesen werden.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Bioorganic & Medicinal Chemistry Letters 4 (1994), S. 2597-2600 
    ISSN: 0960-894X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Chromatographia 4 (1971), S. 578-587 
    ISSN: 1612-1112
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Es wird eine Zusammenstellung der neuesten Arbeiten auf dem Gebiet der Affinitäts-Chromatographie neben deren Möglichkeiten und Grenzen zur Protein-insbesondere Enzymtrennung und-reinigung gegeben. Die dabei berücksichtigte Literatur umfaßt hauptsächlich die Arbeiten der Jahre 1969 bis Frühjahr 1971, welche tabellarisch zusammengefaßt wurden. Verschiedene „Affinoren” und Matrizen werden diskutiert, und durch den zusätzlichen Vergleich mit der Stabilisierung von Enzymen an Matrizen kritisch beleuchtet.
    Abstract: Résumé La présente publication donne une revue des travaux récemment publiés dans le domaine de la «chromatographie d'affinité», et décrit les possibilités et les limites de la méthode en ce qui concerne le domaine de la séparation et de la purification des protéines et notamment d'enzymes. La littérature scientifique analysée est principalement celle parue entre 1969 et le printemps de 1971; elle est présentée sous forme de tableau. Quelques radicaux doués d'affinité spécifique pour les solutés («groupes actifs») et supports inertes de radicaux doués d'affinité spécifique pour les solutés («matrices») sont étudiés et leurs propriétés analysées d'une façon critique du point de vue de la stabilisation des enzymes sur ces supports chromatographiques (phase fixe).
    Notes: Summary This review covers the latest publications in the field of affinity chromatography and its merits and limits for the isolation and purification of proteins, with particular emphasis on enzymes. The literature considered in this survey includes mainly, in tabulated form, the papers published from 1969 to spring 1971. Various “affinants” and matrices are discussed and critically appraised with a view to the stabilisation of enzymes on matrices.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Chromatographia 6 (1973), S. 167-173 
    ISSN: 1612-1112
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Chromatographic investigations with two enzymes and selected low-molecular-weight compounds of different pka on three different “inert” gels (matrices) commonly used for enzyme separation and immobilization showed that considerable deviations from the theoretical elution volumes occur at low ionic strength. These deviations are explained in terms of ionic and hydrophobic interaction between gel matrix and solute.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-2307
    Keywords: Adenocarcinoma Gastroesophageal junction Loss of heterozygosity Microsatellite instability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Adenocarcinoma of the gastroesophageal junction is rapidly rising in incidence. It has been proposed that these tumors be classified as three different types: distal esophageal (AEG I), cardia (AEG II), and subcardia (AEG III). Using comparative genomic hybridization (CGH) analysis, one recent study reported that the 14q chromosomal arm showed a significantly higher rate of deletion in esophageal than in cardia adenocarcinoma. Using a microsatellite analysis technique, we analyzed this area and regions in the vicinity of the APC, DCC, and p53 genes. Tumor and normal tissues were microdissected from 54 cases (27 AEG I and 27 AEG III). DNA was extracted and then amplified using seven fluorescent-labeled microsatellite markers, one pair each on 5q, 18q, and 17p and four on 14q. The results were analyzed for loss of heterozygosity (LOH) and microsatellite instability (MSI). LOH varied from 20% to 30% at each locus except for the 17p locus, where it was slightly above 50% in both groups. No significant differences in LOH or MSI were found between the esophageal and gastric tumors, including the 14q chromosomal arm. These results fail to confirm the finding that abnormalities on the 14q chromosomal arm distinguish between distal esophageal and proximal gastric tumors.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Letters Edition 12 (1974), S. 697-710 
    ISSN: 0360-6384
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Letters Edition 13 (1975), S. 701-709 
    ISSN: 0360-6384
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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