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  • 1
    Electronic Resource
    Electronic Resource
    Tissue ascorbic acid and polyol pathway metabolism in experimental diabetes (1998)
    Springer
    Diabetologia 41 (1998), S. 516-523 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Ascorbic acid ; polyol pathway ; streptozotocin-diabetic rat ; spontaneously diabetic BB rat ; oxidative stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Previous studies demonstrating reduced plasma concentrations of ascorbic acid (AA) in diabetes and interactions between this vitamin and biochemical mechanisms such as synthesis of structural proteins, oxidative stress, polyol pathway and non-enzymatic glycation of proteins suggest that disturbed AA metabolism may be important in the pathogenesis of diabetic microangiopathy. However, limited information is available on the concentration of AA in tissues which develop diabetic complications. This study demonstrates reduced renal but not sciatic nerve or plasma AA concentration in two animal models of insulin-dependent diabetes mellitus, namely the STZ-diabetic rat and the spontaneously diabetic BB rat. Decreased lens AA concentration was also observed in STZ-diabetic rats. Improvement of glycaemic control by insulin treatment (albeit insufficient to achieve normoglycaemia) partially corrected lens and renal AA concentration in STZ-diabetic rats. AA treatment increased kidney and lens AA concentrations of STZ-diabetic and non-diabetic rats and corrected the abnormalities observed for untreated diabetic rats. Sciatic nerve AA concentration was not increased by AA treatment in any group. Tissue ratios of dehydroascorbic acid (DHAA)/AA, one index of oxidative stress, were not different between the diabetic and non-diabetic groups and were unaltered by AA supplementation. AA treatment of STZ-diabetic rats had no effect on elevated tissue concentrations of glucose, sorbitol and fructose or reduced myo-inositol concentration. The effect of reduced tissue AA levels in diabetes on either collagen synthesis or ability to combat increased free radical production is not known. However, correction of abnormal kidney and lens AA concentrations in experimental diabetes by AA supplementation suggests that if AA does have a role in the development or progression of the renal and ocular complications of diabetes, this treatment could be beneficial. [Diabetologia (1998) 41: 516–523]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050940
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of thiocyanate on nitrosation of amines (1974)
    [s.l.] : Nature Publishing Group
    Nature 248 (1974), S. 601-602 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] FIG. 1 Initial rate of reaction of N-methylaniline (0.1 mM) and sodium nitrite (0.1 mM) with various concentrations of sodium thiocyanate against pH at 25 C. a, thiocyanate absent; b, 0.025 mM thiocyanate; c, 0.1 mM thiocyanate; d, 0.25 mM thiocyanate; e, 1.0 mM thiocyanate. The volume of saliva ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/248601a0
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  • 3
    Electronic Resource
    Electronic Resource
    Genetic mapping and functional analysis of a nodulation-defective mutant (sym19) of pea (Pisum sativum L.) (1999)
    Springer
    Molecular genetics and genomics 262 (1999), S. 1-11 
    Details
    ISSN: 1617-4623
    Keywords: Key words Root nodule ; ENOD12 ; Rhizobium ; Sym19 ; Symbiosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The pea mutant line P55 is defective in root nodule formation, and this phenotype is controlled by a single recessive gene. Complementation analysis revealed that the mutation in P55 is allelic to sym19, which has previously been mapped to linkage group I. Detailed mapping revealed that the sym19 and ENOD40 loci are separated by 2.7 cM. We identified four recombination events, demonstrating that the nodulation defect caused by mutation of the sym19 locus cannot be due to mutation of ENOD40. RT-PCR experiments showed that P55 expresses ENOD12A, but there was little or no increase in the level of its transcript in response to Nod factor or infection with Rhizobium. To investigate this expression pattern further, transgenic peas carrying a pENOD12A-GUS reporter construct were made. One transgenic line was crossed with line P55, to generate F2 progeny homozygous for sym19 and carrying pENOD12A-GUS. In both WT and sym19 mutant lines, ENOD12A-GUS expression was induced at sites of lateral root emergence in uninoculated plants. In Nod+ plants pENOD12A-GUS was induced in response to Rhizobium leguminosarum bv. viciae, but no such induction was seen in the Nod− (sym19) mutants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004380051053
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  • 4
    Electronic Resource
    Electronic Resource
    Applied studies on immobilized titanium dioxide films ascatalysts for the photoelectrochemical detoxification of water (1997)
    Springer
    Journal of applied electrochemistry 27 (1997), S. 385-395 
    Details
    ISSN: 1572-8838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract Preliminary results are presented on the photochemical and photoelectrochemical degradation of aqueous organic solutions by anodic, thermal and sol–gel TiO2 films. The films were tested in a photochemical falling film reactor, and a photochemical/photoelectrochemical vortex reactor, and preliminary results are presented on the degradation of a range of model organics using these reactors. The former showed the best mass transport characteristics and most efficient light usage, whilst the latter reactor clearly showed the efficacy of the electric field enhancement effect. The results on the vortex reactor effectively represent a proof-of-concept of the electric field enhancement approach in large scale photoelectrochemical reactors. From time to time it is necessary to recoat the substrates, and the importance of the procedure adopted to remove ’old‘ TiO2 films prior to the fabrication of ‘new’ films is highlighted, as well as the mode of operation of the sol–gel films, and problems encountered in reactor design.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018453402332
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  • 5
    Electronic Resource
    Electronic Resource
    Poster Presentations (1993)
    Springer
    Diseases of the colon & rectum 36 (1993), S. P23 
    Details
    ISSN: 1530-0358
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02053959
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  • 6
    Electronic Resource
    Electronic Resource
    Anionic syntheses of terminally functionalized ethylene oligomers (1989)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 27 (1989), S. 4205-4226 
    Details
    ISSN: 0887-624X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Synthetic procedures for preparation of terminally functionalized linear ethylene oligomers are described. The preferred synthetic method is anionic oligomerization of ethylene with n-butyllithium-tetramethylethylenediamine and electrophilic substitution of the living oligomer so-formed. Conditions and procedures for subsequent chemistry to elaborate the end groups of these oligomers are described. These procedures afford strictly linear ethylene oligomers which contain a wide variety of end groups and which range in molecular weight from 1000 to 4500 (Mn). The product oligomers were characterized spectroscopically as toluene-d8 solutions at 110°C using multinuclear NMR, FT-IR, fluorescence, and UV-visible spectroscopies as appropriate. Alternative stepwise approaches to such oligomers are also discussed.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1989.080271226
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