ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
For dental/orthopedic implants to achieve better bone apposition and bone-implantbonding, various approaches to improve titanium surfaces have been developed. Recently, afluoridated hydroxyapatite (FHA) coating on titanium (Ti) implants was made by sol–gel methodand shown to be a possible applicative bone implant. The purpose of the current study was toevaluate biological responses and biomechanical bonding strength of FHA coated Ti implants ascompared with that of the conventional Ti alloys and hydroxyapatite (HA) coated Ti implants. Invitro assays were made using human osteoblast-like cell (MG63) culture on different implants withcell attachment, morphology and differentiation evaluations. The implant plates were alsoimplanted into the proximal metaphysis of New Zealand White rabbit tibiae. After 8 and 16 weeksimplantation, mechanical and histological assessments were performed to evaluate biomechanicaland biological behavior in vivo. The results showed that the cell adhesion and cell growth rate onthe FHA and HA surface was higher than that on cp Ti surface (p〈0.01), and insignificantdifference was observed between two coated groups. Mechanical test demonstrated that the FHAimplants had a higher interface shear strength than the both controls at 8 and 16 wks, with nosignificant difference with HA-Ti. Histologically, the coated implants revealed a significantlygreater percentage of bone-implant contact when compared with the uncoated implants. Resultsdemonstrated that the new FHA surface improved cell adhesion and proliferation. The coatingexhibited a bioactive mechanical and histological behavior at bone-implant interface, suggestingthat a useful approach by combined coating processes could optimize implant surfaces for bonedeposition and early implant fixation
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.361-363.1087.pdf
Permalink
