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  • 1
    Electronic Resource
    Electronic Resource
    Functional role of 5-HT2 receptors in the regulation of sleep and wakefulness in the rat (1989)
    Springer
    Psychopharmacology 97 (1989), S. 436-442 
    Details
    ISSN: 1432-2072
    Keywords: Sleep ; 5-Hydroxytryptamine (5-HT) ; Antagonist ; Agonist ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recently developed agents specifically acting on different 5-hydroxytryptamine (5-HT) receptor populations were used to analyze the functional role of 5-HT2 receptor subtypes in the sleep-wakefulness cycle of the rat. The 5-HT2 receptor antagonist ritanserin injected intraperitoneally (IP) (0.04–2.5 mg/kg) induced an increase in deep slow wave sleep (SWS2) duration at the expense of wakefulness (W), light slow wave sleep (SWS1) and paradoxical sleep (PS). The stimulation of 5-HT2 receptors by 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) produced a dose-related increase in W and a dose-dependent decrease in both SWS2 and PS. Pretreatment with ritanserin (0.16–2.5 mg/kg) or with cinanserin (2.5–5 mg/kg), another 5-HT2 receptor antagonist, dose-dependently reversed the W enhancement and the SWS2 deficit produced by DOM, but not the PS deficit. Sleep-wakefulness alterations (increase in W and SWS1 combined with a suppression of SWS2 and PS) observed after IP injection of two putative 5-HT1 receptor agonists, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) (2.5 mg/kg) and 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (RU 24969) (0.63 mg/kg), were not modified by ritanserin pretreatment (0.16–2.5 mg/kg). These results further support the hypothesis that the serotonergic system plays an active role in the regulation of the sleep-wakefulness cycle in the rat and that 5-HT2 receptors are involved in this action. In addition it is suggested that 5-HT1 receptor subtypes are unlikely to interact with 5-HT2 receptors in the sleep-wakefulness modulation mediated through 5-HT2 receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00439544
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Differential antagonism by the anticholinergic dexetimide of inhibitory effects of haloperidol and fentanyl on brain self-stimulation (1975)
    Springer
    Psychopharmacology 41 (1975), S. 229-235 
    Details
    ISSN: 1432-2072
    Keywords: Haloperidol ; Fentanyl ; Dexetimide ; Brain Self-Stimulation ; Medial Forebrain Bundle ; Dopamine ; Neostriatum ; Antipsychotic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Haloperidol (0.08 mg/kg) or fentanyl (0.16 mg/kg) injected subcutaneously suppressed bar-pressing for brain-stimulation in rats, implanted with electrodes in the lateral hypothalamic area of the medial forebrain bundle. Increasing doses: 0.04, 0.16, 0.63 and 2.50 mg/kg of the central anticholinergic dexetimide gradually antagonized the haloperidol effects. The highest dose of dexetimide did not reduce the fentanyl-induced inhibition. The results, together with a literature survey on the anticholinergic effects on neuroleptic-induced catalepsy and inhibition of avoidance behavior, are related to biochemical findings and clinical effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428929
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Differential antagonism by naloxone of inhibitory effects of haloperidol and morphine on brain self-stimulation (1974)
    Springer
    Psychopharmacology 37 (1974), S. 303-310 
    Details
    ISSN: 1432-2072
    Keywords: Haloperidol ; Morphine ; Naloxone ; Brain Self-Stimulation ; Catalepsy ; Catatonia ; Ptosis ; Medial Forebrain Bundle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Haloperidol (0.16 mg/kg) or morphine sulfate (40 mg/kg), injected subcutaneously, completely suppressed bar-pressing for brain self-stimulation in rats implanted with electrodes in the lateral hypothalamus. Haloperidol also caused catalepsy and ptosis while morphine produced catatonia with exophthalmia. Naloxone in a dose (5 mg/kg) which was ineffective when given alone, differentially reversed the morphine-effects but was without any reversing influence on the actions of haloperidol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428916
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Intracranial self-stimulation in rats as a function of various stimulus parameters (1976)
    Springer
    Psychopharmacology 46 (1976), S. 179-183 
    Details
    ISSN: 1432-2072
    Keywords: Fentanyl ; Piritramide ; Morphine ; Catatonia ; Self-stimulation ; Medial forebrain bundle ; Stimulus parameter combinations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of different subcutaneous doses of fentanyl (0.02, 0.04, 0.08, and 0.16 mg/kg), piritramide (0.63, 2.50, 10.0, and 40.0 mg/kg), and morphine (2.50, 5.00, 10.0, and 20.0 mg/kg) on self-stimulation in rats were studied. Different stimulus parameter combinations (SPC) inducing low, high, or intermediate control response rates (CRR) were applied during the same experimental sessions. The three narcotic analgesics induced response depression (RD) and response stimulation (RS). RS was mostly observed at low dose levels; RD was dose-related. SPC's inducing low CRR were more sensitive than those inducing high CRR. Fentanyl was more potent than piritramide and than morphine. The RD is related to motor incapacitation, as the doses needed to effectively reduce self-stimulation also induced obvious catatonia. The RS probably is a more specific effect reflecting sensitization of structures involved in reinforcement of behavior.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421389
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    Paper (German National Licenses)
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