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  • 1
    Electronic Resource
    Electronic Resource
    Asymptomatic encephalic intraparenchymatous neuroepithelial cysts (1984)
    Springer
    Acta neuropathologica 63 (1984), S. 264-268 
    Details
    ISSN: 1432-0533
    Keywords: Neuroepithelial cyst ; Ependymal cyst ; Intraparenchymatous cyst
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The authors report three cases of intraparenchymatous neuroepithelial cysts, which did not communicate with the ventricular system and the subarachnoid space. They were located in (1) the right frontal lobe, (2) the left cerebral peduncle and pons, and (3) the right cerebellar hemisphere. All of them were asymptomatic, despite their volume and location, and presented as incidental autopsy findings. A developmental origin is likely for these non-neoplastic cysts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685253
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  • 2
    Electronic Resource
    Electronic Resource
    Computed tomography evaluation of radiolucent gallstones in vivo (1990)
    Springer
    Abdominal imaging 15 (1990), S. 58-60 
    Details
    ISSN: 1432-0509
    Keywords: Abdomen, computed tomography ; Gallstone, calcification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Computed tomography facilitates an in vivo classification of gallstones and can aid in the identification of calcifications that escape detection with conventional radiologic procedures. Of patients with radiolucent stones, 54.8% exhibited calcifications either in the form of discrete rims (41.9%) or at the center of the stone (12.9%). Densities of the noncalcified areas of partially calcified stones averaged 40.68±6.8 Hounsfield units (HU), which was not significantly higher than the average of 31.85±3.19 HU for noncalcified stones. Calcified regions showed significantly higher densities (240.0±28.6 HU,p〈 0.001,x ± SEM). Of the identified stones, 16.1% showed densities greater than 50 HU. These were primarily bilirubin stones, which cannot yet be treated successfully with conservative therapeutic modalities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01888736
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  • 3
    Electronic Resource
    Electronic Resource
    Ultrasound, computed tomography and endoscopic retrograde cholangiopancreatography in the morphologic diagnosis of pancreatic disease (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 291-296 
    Details
    ISSN: 1432-1440
    Keywords: Ultrasound ; Computed tomography ; Endoscopic retrograde cholangiopancreatography ; Chronic pancreatitis ; Pancreatic tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary From February to November 1981 the diagnostic relevance of ultrasound (US), computed tomography (CT) and endoscopic retrograde cholangiopancreatography (ERCP) was compared prospectively in 75 patients with suspected pancreatic disease. Final diagnosis was confirmed by autopsy, surgery, clinical course, and further laboratory data. Thus it was possible to exclude pancreatic disorders in 32 patients. By ERCP we diagnosed all tumors; sensitivity was 100%. Sensitivity of US and CT were 63% each. In five cases US made the false positive diagnosis” pancreatic malignant tumor” (specifity 93%), CT and ERCP in two cases (specifity 97% each). In chronic pancreatitis specifity of US and ERCP were 100% and specifity of CT was 98%. Sensitivity of ERCP amounted to 93%, CT and US revealed 74% and 52%, respectively. We conclude that ERCP is the best morphologic diagnostic tool in differentiating chronic pancreatitis from pancreatic carcinoma. US is a good screening method and CT reveals good diagnostic results in acute pancreatitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01497778
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  • 4
    Electronic Resource
    Electronic Resource
    Wirkung von Bezafibrat bei primären Hyperlipidämien (1982)
    Springer
    Journal of molecular medicine 60 (1982), S. 97-105 
    Details
    ISSN: 1432-1440
    Keywords: Hyperlipidemia ; Lipoproteins ; Bezafibrate ; Lipoprotein-Lipase ; Hyperlipidämie ; Lipoproteine ; Bezafibrat ; Lipoprotein-Lipase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Wirkung von Bezafibrat auf Lipid- und Lipoproteinspiegel wurde in einer Langzeitstudie über 40 Wochen bei 27 Patienten mit primären Hyperlipoproteinämien untersucht (12 Patienten mit HLP Typ IV n.F., 7 Patienten mit Typ IIb, 3 Patienten mit Typ IIa, 4 Patienten mit Typ V und 1 Patient mit Typ III). Bezafibrat senkte in diesem Kollektiv das Gesamtcholesterin um 16%, während das HDL-Cholesterin um 28 bzw. 36% anstieg (p〈0,05). Die Serumtriglyzeride fielen um 59% (450 mg Bezafibrat/die) bzw. 66% (600 mg Bezafibrat/die) statistisch signifikant ab (p〈0,05). Bei Hyperlipidämien vom Typ IV, IIb, IIa und V waren Anstiege des HDL-Cholesterins feststellbar. Das LDL-Cholesterin verhielt sich typenspezifisch. Die Aktivität der Lipoproteinlipasen (postheparin) wurde durch Bezafibrat von 10,5±0,7 auf 14,7±0,7 bzw. 15,5±0,8 µmol FFA/ml/Stunde um ca. 30% gesteigert (p〈0,05). Die Nebenwirkungen während Bezafibrat-Behandlung waren gering.
    Notes: Summary The effect of long-term treatment over 40 weeks with Bezafibrate on lipids and lipoproteins was investigated in 27 patients with primary hyperlipoproteinemias (hlp) (12 patients with hlp type IV, 7 patients with type IIb, 3 patients with type IIa, 4 patients with type V and 1 patient with type III). Bezafibrate reduced total cholesterol by 16%, whereas HDL-cholesterol increased by 28% and 36% (p〈0.05). Serumtriglycerides decreased by 59% (450 mg Bezafibrate daily) and by 66% (600 mg Bezafibrate daily) statistically significant (p〈0.05). In hyperlipidemias type IV, IIb, IIa and V increases of HDL-cholesterol could be observed. The course of LDL-cholesterol was different in the various types of hlp. The postheparin-lipoprotein-lipase (PHLA) was activated by treatment with Bezafibrate from 10.5±0.7 to 14.7±0.7 and 15.5±0.8 µmol FFA/ml/h or by 30% (p〈0.05). Only few side-effects during treatment with Bezafibrate could be ascertained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716387
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  • 5
    Electronic Resource
    Electronic Resource
    Mutation and identification of the F plasmid locus determining resistance to acridine orange curing
    Amsterdam : Elsevier
    Plasmid 4 (1980), S. 276-280 
    Details
    ISSN: 0147-619X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0147-619X(80)90066-9
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  • 6
    Electronic Resource
    Electronic Resource
    Symptoms associated with malignancy of peripheral nerve sheath tumours: a retrospective study of 69 patients with neurofibromatosis 1 (2005)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 153 (2005), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Neurofibromatosis 1 (NF1) is a common genetic disorder with variable clinical manifestations and an unpredictable course. Plexiform neurofibromas are common complications of NF1. Their malignant transformation is the main cause of mortality in adult patients with NF1.Objectives  To identify clinical factors associated with malignant transformation of plexiform neurofibromas.Methods  Using the database of our neurofibromatosis clinic we included in a retrospective study all patients with NF1 having at least one peripheral nerve sheath tumour for which they underwent surgery or surgical biopsy. Predictive values for malignant transformation of three clinical symptoms, i.e. pain, enlargement of mass and neurological symptoms, were evaluated in association with histological parameters.Results  Of 69 patients studied, 48 had at least one plexiform neurofibroma and 21 had a malignant peripheral nerve sheath tumour. Only enlargement of the tumour had high negative and positive predictive values for malignant transformation: 0·92 and 0·95, respectively. In multivariate analysis, tumour enlargement was independently associated with malignant transformation (odds ratio 167·8, 95% confidence interval 14·0–2012·1).Conclusions  From a practical point of view, pain, neurological deficit and enlargement of a pre-existing peripheral nerve sheath tumour in NF1 must lead to deep surgical biopsy to rule out malignant transformation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2005.06558.x
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  • 7
    Electronic Resource
    Electronic Resource
    Eruptive angiomatous lesions associated with graft-versus-host disease (2003)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 149 (2003), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2003.05504.x
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  • 8
    Electronic Resource
    Electronic Resource
    Isolation of a CD8αα+ CD4– tumour T-cell clone with cytotoxic activity from a CD4+ CD8– cutaneous T-cell lymphoma (2003)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 148 (2003), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  We have previously established tumour T-cell lines, both from the skin and from the blood of patients with a cutaneous T-cell lymphoma (CTCL). In one patient, the tumour cells and the derived cell lines had a CD3+ CD4+ CD8– phenotype and a trisomy of chromosome 7. They expressed three T-cell receptor (TCR) β-chain transcripts, but only one was productively rearranged and expressed at the cell membrane.Objectives  In the present study, we tried to isolate a fast-growing new tumour T-cell line from the same patient.Patients/methods  We performed direct cell cloning of the skin tumour lymphocyte population, which led to the isolation of an interleukin-2-dependent highly proliferative T-cell subclone, named Cou-L3, with a CD3+ TCR-Vβ13+ CD4– CD8αα+ phenotype.Results  We demonstrated that Cou-L3 was identical to the original clonal tumour CD3+ Vβ13+ CD4+ CD8– cells, as it expressed the same rearranged TCR-Vβ13 chain. We further studied the functional activity of these CD8αα+ Vβ13+ Cou-L3 cells. We found that these cells exhibited CD3-redirected cytotoxic activity.Conclusions  An immunophenotypic shift, with a change from a CD4+ to a CD8+ phenotype, has been already reported in association with disease progression in CTCL. However, in these cases, there has been no demonstration that the phenotypic change involved the same T-cell clone. The present study is the first report of the phenotypic heterogeneity of the tumour clonal cell population in CTCL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2003.05015.x
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  • 9
    Electronic Resource
    Electronic Resource
    Erythrodermic cutaneous T-cell lymphoma with disseminated pustulosis. Production of high levels of interleukin-8 by tumour cells (2001)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 144 (2001), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Interleukin (IL) -8 is a neutrophil chemoattractant cytokine with proinflammatory and growth-promoting activities, which is involved in the pathogenesis of several inflammatory diseases. It is found in high amounts in lesional biopsies of pustular diseases such as psoriasis and palmoplantar pustulosis. We report a 50-year-old woman with a 10-year history of erythroderma with disseminated pustulosis. Skin biopsies showed an epidermotropic infiltrate composed of atypical CD4+ CD8+ lymphocytes with numerous admixed neutrophils. Peripheral blood flow cytometric analysis revealed a major clonal subset of CD3+ CD4+ CD8+ T-cell receptor Vβ22+ atypical lymphocytes. Bone marrow biopsy, lymph node biopsy and computed thoracoabdominal tomography were normal. Serologies for human T-cell lymphotropic virus type I and human immunodeficiency virus were negative. Our patient’s status deteriorated despite topical (nitrogen mustard, psoralen plus ultraviolet A) and systemic (interferon, methotrexate, multiagent chemotherapy) treatments, and she finally died. We showed that our patient’s peripheral blood lymphocytes (PBL) spontaneously produced high amounts of IL-8. In contrast, PBL of patients with classical Sézary syndrome produced lower amounts of IL-8. The production of IL-8 by tumour T cells could explain this unusual clinical and histopathological presentation of cutaneous T-cell lymphoma as disseminated pustulosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2001.04203.x
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  • 10
    Electronic Resource
    Electronic Resource
    Amicrobial pustulosis associated with autoimmune diseases: healing with zinc supplementation (2000)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 143 (2000), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Amicrobial pustulosis associated with autoimmune diseases is an eruption involving the cutaneous flexures and scalp. We report two young women with this disease, in whom pustulosis healed with zinc supplementation. We suggest that it may be relevant to measure plasma zinc level in patients with such a disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2000.03907.x
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