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  • 1
    Electronic Resource
    Electronic Resource
    Computed tomography evaluation of radiolucent gallstones in vivo (1990)
    Springer
    Abdominal imaging 15 (1990), S. 58-60 
    Details
    ISSN: 1432-0509
    Keywords: Abdomen, computed tomography ; Gallstone, calcification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Computed tomography facilitates an in vivo classification of gallstones and can aid in the identification of calcifications that escape detection with conventional radiologic procedures. Of patients with radiolucent stones, 54.8% exhibited calcifications either in the form of discrete rims (41.9%) or at the center of the stone (12.9%). Densities of the noncalcified areas of partially calcified stones averaged 40.68±6.8 Hounsfield units (HU), which was not significantly higher than the average of 31.85±3.19 HU for noncalcified stones. Calcified regions showed significantly higher densities (240.0±28.6 HU,p〈 0.001,x ± SEM). Of the identified stones, 16.1% showed densities greater than 50 HU. These were primarily bilirubin stones, which cannot yet be treated successfully with conservative therapeutic modalities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01888736
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  • 2
    Electronic Resource
    Electronic Resource
    Ultrasound, computed tomography and endoscopic retrograde cholangiopancreatography in the morphologic diagnosis of pancreatic disease (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 291-296 
    Details
    ISSN: 1432-1440
    Keywords: Ultrasound ; Computed tomography ; Endoscopic retrograde cholangiopancreatography ; Chronic pancreatitis ; Pancreatic tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary From February to November 1981 the diagnostic relevance of ultrasound (US), computed tomography (CT) and endoscopic retrograde cholangiopancreatography (ERCP) was compared prospectively in 75 patients with suspected pancreatic disease. Final diagnosis was confirmed by autopsy, surgery, clinical course, and further laboratory data. Thus it was possible to exclude pancreatic disorders in 32 patients. By ERCP we diagnosed all tumors; sensitivity was 100%. Sensitivity of US and CT were 63% each. In five cases US made the false positive diagnosis” pancreatic malignant tumor” (specifity 93%), CT and ERCP in two cases (specifity 97% each). In chronic pancreatitis specifity of US and ERCP were 100% and specifity of CT was 98%. Sensitivity of ERCP amounted to 93%, CT and US revealed 74% and 52%, respectively. We conclude that ERCP is the best morphologic diagnostic tool in differentiating chronic pancreatitis from pancreatic carcinoma. US is a good screening method and CT reveals good diagnostic results in acute pancreatitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01497778
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  • 3
    Electronic Resource
    Electronic Resource
    Wirkung von Bezafibrat bei primären Hyperlipidämien (1982)
    Springer
    Journal of molecular medicine 60 (1982), S. 97-105 
    Details
    ISSN: 1432-1440
    Keywords: Hyperlipidemia ; Lipoproteins ; Bezafibrate ; Lipoprotein-Lipase ; Hyperlipidämie ; Lipoproteine ; Bezafibrat ; Lipoprotein-Lipase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Wirkung von Bezafibrat auf Lipid- und Lipoproteinspiegel wurde in einer Langzeitstudie über 40 Wochen bei 27 Patienten mit primären Hyperlipoproteinämien untersucht (12 Patienten mit HLP Typ IV n.F., 7 Patienten mit Typ IIb, 3 Patienten mit Typ IIa, 4 Patienten mit Typ V und 1 Patient mit Typ III). Bezafibrat senkte in diesem Kollektiv das Gesamtcholesterin um 16%, während das HDL-Cholesterin um 28 bzw. 36% anstieg (p〈0,05). Die Serumtriglyzeride fielen um 59% (450 mg Bezafibrat/die) bzw. 66% (600 mg Bezafibrat/die) statistisch signifikant ab (p〈0,05). Bei Hyperlipidämien vom Typ IV, IIb, IIa und V waren Anstiege des HDL-Cholesterins feststellbar. Das LDL-Cholesterin verhielt sich typenspezifisch. Die Aktivität der Lipoproteinlipasen (postheparin) wurde durch Bezafibrat von 10,5±0,7 auf 14,7±0,7 bzw. 15,5±0,8 µmol FFA/ml/Stunde um ca. 30% gesteigert (p〈0,05). Die Nebenwirkungen während Bezafibrat-Behandlung waren gering.
    Notes: Summary The effect of long-term treatment over 40 weeks with Bezafibrate on lipids and lipoproteins was investigated in 27 patients with primary hyperlipoproteinemias (hlp) (12 patients with hlp type IV, 7 patients with type IIb, 3 patients with type IIa, 4 patients with type V and 1 patient with type III). Bezafibrate reduced total cholesterol by 16%, whereas HDL-cholesterol increased by 28% and 36% (p〈0.05). Serumtriglycerides decreased by 59% (450 mg Bezafibrate daily) and by 66% (600 mg Bezafibrate daily) statistically significant (p〈0.05). In hyperlipidemias type IV, IIb, IIa and V increases of HDL-cholesterol could be observed. The course of LDL-cholesterol was different in the various types of hlp. The postheparin-lipoprotein-lipase (PHLA) was activated by treatment with Bezafibrate from 10.5±0.7 to 14.7±0.7 and 15.5±0.8 µmol FFA/ml/h or by 30% (p〈0.05). Only few side-effects during treatment with Bezafibrate could be ascertained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716387
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  • 4
    Electronic Resource
    Electronic Resource
    Adipositas und Fettstoffwechselstörungen (1997)
    Springer
    Der Internist 38 (1997), S. 231-236 
    Details
    ISSN: 1432-1289
    Keywords: Schlüsselwörter Adipositas ; Adipositas ; Dyslipoproteinämie ; Adipositas ; Fettstoffwechsel ; Adipositas ; Therapie ; Fettstoffwechsel ; Dyslipoproteinämie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zum Thema Die Adipositas steht in enger Relation zu Fettstoffwechselstörungen. Über die unterschiedlichen Lipoproteinklassen, die Zusammensetzung der Lipoproteine sowie die Lipolyse bei Adipositas wird hier eingehend berichtet. Auch die verschiedenen Fettverteilungstypen sind von Wichtigkeit in ihrer Beziehung zur Ausprägung der Fettstoffwechselstörungen und deren Komplikationen, in erster Hinsicht also den arteriosklerotischen Erkrankungen. Gewichtsreduktion und körperliche Aktivität haben einen positiven prognostischen Wert bezüglich der Dyslipoproteinämie und sind somit die therapeutischen Säulen dieser Volkskrankheit im wahrsten Sinne des Wortes, unter der hierzulande, je nach Definitionskriterien, 10–50% der Bevölkerung leiden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00002638
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  • 5
    Electronic Resource
    Electronic Resource
    Fish oil, enriched with polyunsaturated fatty acids of the omega-3-type accelerates the nucleation time in healthy subjects (1991)
    Springer
    Journal of molecular medicine 69 (1991), S. 289-293 
    Details
    ISSN: 1432-1440
    Keywords: Omega-3-fatty acids ; PUFA ; Nucleation time ; Cholesterol saturation index ; Diet ; Polyunsaturated fatty acids ; Biliary lipids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The daily administration of fish oil, containing 1.5 g omega-3-fatty acids causes a significant decrease in nucleation time (12.1 ±7.3 vs. 2.0 ±1.2 days, p〈 0.001), as well as in biliary cholesterol saturation and biliary cholesterol composition in 13 healthy subjects. The nucleation time, cholesterol saturation index and biliary lipids showed no significant differences in 11 cholesterol gallstone patients after a six-week treatment period with omega-3-fatty acids. Taurocholate percentage increased significantly in the gallstone group (10.4 ±3.9 vs 13.5 ±1.7%, p〈0.05). The levels of the other bile acids remained unchanged during the treatment period. Therefore, the incidence of gallstones might be increased after treatment with fish oil, containing omega-3-fatty acids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01644757
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  • 6
    Electronic Resource
    Electronic Resource
    The relationship between serum lipids, nucleation time, and biliary lipids in patients with gallstones (1992)
    Springer
    Journal of molecular medicine 70 (1992), S. 430-436 
    Details
    ISSN: 1432-1440
    Keywords: Gallstones ; Serum cholesterol ; High density lipoprotein (HDL)-cholesterol ; Low density lipoprotein (LDL)-cholesterol ; triglycerides ; Nucleation time ; cholesterol saturation index ; Total lipid concentration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The relationship between biliary lipids, cholesterol saturation index, nucleation time, and serum lipids was studied in a group of 45 gallstone patients (10 male, 35 female; age 50.1 ±14.5 years). Bile was obtained by direct fine-needle puncture of the gallbladder under local anesthesia and sonographic monitoring. No significant correlation between the serum lipids and either the cholesterol saturation index or total biliary cholesterol levels was observed. We found a positive correlation between the nucleation time and serum triglycerides content (r = 0.45, p = 0.0018) and a negative correlation between nucleation time and biliary cholesterol level (r = −0.38, p = 0.009). The fatty acids derived from the triglycerides are primarily resynthesized to phospholipids in the liver. When the supply of free fatty acids exhausts the metabolic capacity of the liver as, for example, in fat-rich diets, triglycerides accumulate in the liver cells and may possibly be excreted in the bile. Free fatty acids stimulate mucin hypersecretion in the gallbladder. This mucosal hypersecretion has been assigned a significant role in the formation of gallbladder stones. We also found a positive correlation between the total biliary bile acids and serum high density lipoprotein (HDL)-cholesterol in patients with a rapid nucleation time (r = 0.50, p = 0.0128). This supports the findings of other researchers, which suggests that HDL-cholesterol is devoted primarily to bile acid synthesis. In patients with a short nucleation time, the cholesterol saturation index, total lipid concentration, biliary cholesterol, mean age, and biliary bile acids were statistically different in comparison with patients with a prolonged nucleation time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235527
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  • 7
    Electronic Resource
    Electronic Resource
    Determination of bile acids in serum and bile by a modified gas chromatographic glass capillary technique (1988)
    Springer
    Chromatographia 25 (1988), S. 447-450 
    Details
    ISSN: 1612-1112
    Keywords: Gas chromatography ; Glass capillary columns ; Bile acids ; Hexafluoroisopropyl esters
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A modified gas chromatographic glass capillary technique for determination of five major bile acids (Cholic acid: CA, Chenodeoxycholic acid: CDCA, Deoxycholic acid: DCA, Lithocholic acid: LCA and Ursodeoxycholic acid: UDCA) has been developed after preliminary extraction with XAD-2 resin. Enzymatic hydrolysis prevents the formation of interferring degradation products. Ether extraction with centrifugation eliminates water soluble interferring substances. Derivatization to hexafluorpropyl- instead of methyl esters results in better separation, shortens analysis time and prolongs the life span of the column.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02324790
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