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  • 1
    Electronic Resource
    Electronic Resource
    Influence of cyclodextrins on nitrosation of drugs (1984)
    Springer
    Journal of inclusion phenomena and macrocyclic chemistry 2 (1984), S. 605-611 
    Details
    ISSN: 1573-1111
    Keywords: Nitrosation reactions: α-, β-, γ-cyclodextrin, dimethyl-β-cyclodextrin ; piperazine ; ethambutol ; cimetidine ; 1-ephedrine ; fencamfamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The World Health Organization issued a nitrosation procedure (NAP Test) which allows to carry out nitrosation under standard conditions. It has proved that the in vitro reaction rates of the fast nitrosatable drugs piperazine, cimetidine and ethambutol are not influenced by α-, β- and γ-cyclodextrin. On the contrary, β-, γ-cyclodextrin and heptakis-2,6-di-O-methyl-β-cyclodextrin enhance the nitrosation of the slower nitrosatable 1-ephedrine and fencamfamine significantly. This possible reaction must be considered if nitrosatable drugs are formulated with cyclodextrins to be administered to human beings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00662226
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Nitrosation of mefenorex in the presence of cyclodextrins (1987)
    Springer
    Journal of inclusion phenomena and macrocyclic chemistry 5 (1987), S. 625-629 
    Details
    ISSN: 1573-1111
    Keywords: Nitrosation reactions ; α-, β-, γ-cyclodextrin, dimethyl-β-cyclodextrin ; mefenorex ; nitrosomefenorex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract β- and γ-Cyclodextrin (CD) and heptakis-2,6-di-O-methyl-β-cyclodextrin (DIMEB) form soluble inclusion compounds with mefenorex (MEF); with α-CD a partial inclusion occurs. No solid inclusion compound could be obtained with the four CDs. β-, γ-CD and DIMEB, but not α-CD, enhance the nitrosation rate of MEF if the nitrosation assay procedure (NAP test) is applied. During this reaction with β- and γ-CD, solid inclusion compounds of the CDs and nitrosomefenorex (NMEF) precipitate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00663003
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    In vitro nitrosation of ephedrine in the presence of cyclodextrins (1987)
    Springer
    Journal of inclusion phenomena and macrocyclic chemistry 5 (1987), S. 621-624 
    Details
    ISSN: 1573-1111
    Keywords: Nitrosation reactions ; α-, β-, γ-cyclodextrin ; dimethyl-β-cyclodextrin ; ephedrine ; nitrosoephedrine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract β-, and γ-cyclodextrin and heptakis-2,6-di-O-methyl-β-cyclodextrin enhance the nitrosation rate of l-ephedrine if the nitrosation assay procedure (NAP test) is applied. During this reaction with β-cyclodextrin a solid inclusion compound of β-cyclodextrin andN-nitrosoephedrine precipitates. Solubilities and stabilities of inclusion compounds of the cyclodextrins with ephedrine and nitrosoephedrine, respectively, explain especially the catalytic effects of some cyclodextrins on ephedrine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00663002
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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