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  • 1
    Electronic Resource
    Electronic Resource
    Absorption and magnetic circular dichroism spectra of hexafluoroosmate(IV) and hexafluoroiridate(IV) in the cubic host dicesium hexafluorogermanate (1978)
    s.l. : American Chemical Society
    Inorganic chemistry 17 (1978), S. 2689-2698 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic50188a001
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Determination of Radioactive Gold in Biological Tissue (1954)
    s.l. : American Chemical Society
    Analytical chemistry 26 (1954), S. 586-587 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60087a057
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Prevention of diabetes mellitus in non-obese diabetic mice by Linomide, a novel immunomodulating drug (1994)
    Springer
    Diabetologia 37 (1994), S. 1195-1201 
    Details
    ISSN: 1432-0428
    Keywords: Key words Autoimmunity ; immunomodulation ; insulin-dependent diabetes mellitus ; non-obese diabetic mouse.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Oral administration of the synthetic immunomodulating drug quinoline-3-carboxamide (Linomide) in the drinking water to 5-week-old female non-obese diabetic (NOD) mice resulted in complete protection from insulitis and maintenance of normal glucose tolerance for over 40 weeks (impaired glucose tolerance: treated n = 2 of 18; control n = 17 of 18, p 〈 0.0001). Delayed administration of the drug at 16 weeks resulted in slowing of the progression to diabetes when assessed at 42 weeks (treated with diabetes n = 7 of 25; control with diabetes 25 of 43, p 〈 0.0234). No gross changes of immune system cell phenotype or function were observed in the Linomide-treated group. Adoptive transfer of spleen and lymph node cells from treated female NOD mice into sub-lethally irradiated male recipients failed to transfer diabetes, whereas a similar transfer of cells obtained from untreated age-matched controls resulted in diabetes in all secondary recipients (diabetes in control group n = 12 of 13; in Linomide group n = 0 of 11, p 〈 0.0001). Linomide pretreatment of the secondary recipients also inhibited the transfer of diabetes (diabetes in pretreated group n = 2 of 9, control group n = 12 of 13, p 〈 0.015), as did adoptive co-transfer of cell mixtures obtained from treated female NOD mice, free of diabetes, and from diabetic NOD female mice (diabetes in Linomide group n = 4 of 9; in control group 7 of 7, p 〈 0.0337). Our data indicate that Linomide-treated NOD mice generate immune cells with the capacity to downregulate responses to beta-cell antigens, apparently through immunoregulation rather then antigen non-specific immunosuppression. Based on our findings and considering the lack of severe side effects of orally administered Linomide in man, this new compound should be considered as a potential drug for treatment of insulin-dependent diabetes mellitus. [Diabetologia (1994) 37: 1195–1201]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00399792
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  • 4
    Electronic Resource
    Electronic Resource
    Prevention of diabetes mellitus in non-obese diabetic mice by Linomide, a novel immunomodulating drug (1994)
    Springer
    Diabetologia 37 (1994), S. 1195-1201 
    Details
    ISSN: 1432-0428
    Keywords: Autoimmunity ; immunomodulation ; insulin-dependent diabetes mellitus ; non-obese diabetic mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Oral administration of the synthetic immunomodulating drug quinoline-3-carboxamide (Linomide) in the drinking water to 5-week-old female non-obese diabetic (NOD) mice resulted in complete protection from insulitis and maintenance of normal glucose tolerance for over 40 weeks (impaired glucose tolerance: treated n=2 of 18; control n=17 of 18, p〈0.0001). Delayed administration of the drug at 16 weeks resulted in slowing of the progression to diabetes when assessed at 42 weeks (treated with diabetes n=7 of 25; control with diabetes 25 of 43, p〈0.0234). No gross changes of immune system cell phenotype or function were observed in the Linomide-treated group. Adoptive transfer of spleen and lymph node cells from treated female NOD mice into sub-lethally irradiated male recipients failed to transfer diabetes, whereas a similar transfer of cells obtained from untreated age-matched controls resulted in diabetes in all secondary recipients (diabetes in control group n=12 of 13; in Linomide group n=0 of 11, p〈0.0001). Linomide pretreatment of the secondary recipients also inhibited the transfer of diabetes (diabetes in pretreated group n=2 of 9, control group n=12 of 13, p〈0.015), as did adoptive co-transfer of cell mixtures obtained from treated female NOD mice, free of diabetes, and from diabetic NOD female mice (diabetes in Linomide group n=4 of 9; in control group 7 of 7, p〈0.0337). Our data indicate that Linomide-treated NOD mice generate immune cells with the capacity to downregulate responses to beta-cell antigens, apparently through immunoregulation rather then antigen non-specific immunosuppression. Based on our findings and considering the lack of severe side effects of orally administered Linomide in man, this new compound should be considered as a potential drug for treatment of insulin-dependent diabetes mellitus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00399792
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Über das Wachstum des menschlichen Auges und über die Veränderung der Muskelinsertionen am wachsenden Auge (1897)
    Springer
    Anatomy and embryology 8 (1897), S. 191-248 
    Details
    ISSN: 1432-0568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02243538
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  • 6
    Electronic Resource
    Electronic Resource
    Leiomyoma of the adrenal gland in a patient with AIDS (1994)
    Springer
    Abdominal imaging 19 (1994), S. 259-261 
    Details
    ISSN: 1432-0509
    Keywords: Leiomyoma, adrenal tumor ; AIDS ; CT ; MR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Leiomyoma of the adrenal gland is an exceptional localization. We report a case occurring in a young patient with AIDS. Diagnosis was a surprise on pathologic examination. On enhanced computed tomographic (CT) scan, the adrenal mass had a low central attenuation area and a thin enhancing peripheral ring. On magnetic resonance (MR) imaging the left adrenal mass was isointense with the liver on T1-(TR/TE = 500/ 300 ms) and T2-(TR/TE = 2030/60, 120 ms) weighted spin-echo images, except a central area with a lower signal on T1-weighted images and a higher signal on T2-weighted images. The mass was slightly enhanced after Gd-DOTA injection, but the central area remained unchanged.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00203522
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  • 7
    Electronic Resource
    Electronic Resource
    Evolution of post-natal Herpes simplex virus encephalitis to multicystic encephalopathy (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 666-670 
    Details
    ISSN: 1432-0533
    Keywords: Herpes simplex encephalitis ; Multicystic encephalopathy ; In situ hybridization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 3-week-old, previously healthy infant developed biopsy-proven Herpes virus type 2 (HSV-2) encephalitis. The encephalitis was characterized by cells having intranuclear inclusions and was without evidence of inflammation or hemorrhage. Neuroimaging studies did not show any destructive lesions in the brain. In spite of antiviral therapy, the infant's neurological conditions deteriorated, and the patient died at the age of 18 weeks. Post-mortem examination showed that most of the cerebral hemispheres were replaced by multiloculated cystic cavities of various sizes, typical of multicystic encephalopathy (MCE). The cystic lesions were randomly distributed and were not confined to any vascular territory. By light microscopy, there were no features of viral infection in the brain. Although in situ hybridization of the biopsy specimen taken during the acute phase of the disease demonstrated abundant HSV genome, this same method failed to detect HSV on the post-mortem specimen. These findings suggest that HSV-2 can induce MCE. Furthermore, the absence of histological features of viral encephalitis and the failure to demonstrate viral genome in the brain at autopsy does not exclude an infections etiology in certain cases of MCE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307637
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  • 8
    Electronic Resource
    Electronic Resource
    Coenzym A-Thioester höherer Fettsäuren als mögliche Vermittler enzymatischer Regulationen im Tierkörper (1965)
    Springer
    Journal of molecular medicine 43 (1965), S. 645-654 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Die Schlüsselenzyme Acetyl-CoA-Carboxylase (geschwindigkeitsbegrenzender Schritt der Fettsäuresynthese), Citrat-synthase (einleitender Schritt des Citronensäurecyclus) und Glucose-6-phosphatdehydrogenase (erster Schritt des Hexosemonophosphatabbaues) werden in vitro hochempfindlich durch die Coenzym A-Thioester langkettiger Fettsäuren — vor allem Stearyl-CoA und Palmityl-CoA — gehemmt. Die wirksamen Konzentrationen dieser Verbindungen liegen in gleicher Größenordnung wie diejenigen, die man in der Leber antrifft. Auf Grund der kinetischen Daten kann man vermuten, daß die Coenzym A-Thioester nicht unmittelbar an den katalytischen Enzymzentren angreifen, sondern daß die Hemmung mittelbar (cooperativ) durch (allosterische) Änderungen der Proteinstruktur ausgelöst wird. Die Stellung der betroffenen Enzyme im Stoffwechsel sowie die Ergebnisse ausführlicher in vivo-Untersuchungen machen es wahrscheinlich, daß die langkettigen Fettsäure-Thioester des Coenzym A als körpereigene Wirkstoffe (Kontroll-Metabolite) in die Regulation folgender Stoffwechselabschnitte eingeschaltet sind: a) Die cytoplasmatische Biosynthese langkettiger Fettsäuren aus Acetyl-Coenzym A. b) Die Endoxydation des Acetyl-CoA über den Citronensäurecyclus. c) Den direkten Glucoseabbau über den Hexosemonophosphatweg. Einige pathophysiologische Merkmale des Leberstoffwechsels des akut-dekompensierten Diabetes mellitus und verwandter Zustände — nämlich Hemmung der Lipoidsynthese, gesteigerte Ketonkörperbildung und Unterdrückung des direkten Glucoseabbaues — könnten auf diese Weise unter einem gemeinsamen Nenner erklärt werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728702
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  • 9
    Electronic Resource
    Electronic Resource
    Observations on phase-locking within the response of primary muscle spindle afferents to pseudo-random stretch (1988)
    Springer
    Biological cybernetics 59 (1988), S. 49-54 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract In order to uncover encoder properties of primary muscle spindle afferent fibers, time coupling (phase-locking) of action potentials on cyclic muscle stretch was studied by means of pseudo-random noise. In cats Ia action potentials were recorded from dorsal root filaments and the gastrocnemius muscles of one hind leg were stretched. The stimulus time course was a determined sequence of randomly varying muscle length which could be applied repeatedly (sequence duration 0.6 or 20 s). The noise amplitude σ (standard deviation of displacements) was varied between 5 and 300 μm, the upper cut-off frequency of noise f c was varied between 20 and 100 Hz. The responses to the consecutive pseudo-random noise cycles were displayed as raster diagrams and cycle histograms. Phaselocking characterized the responses at all noise amplitudes outside the near threshold range (σ〉10 μm). The higher σ and f c , the stronger was the phase-locking of impulses on the stretch. When σ and f c were selected to achieve high mean stretch velocities of about 500 mm/s, phase-locking was as precise as 0.15 ms, measured as the variability of spike occurrences with respect to stretch. The rasters obtained with low noise amplitudes (〈40 μm) showed a loose phase-locking and this gave insight into underlying mechanisms: The elicitation of action potentials caused by dynamic stretch can be prevented by a post-spike depression of excitability. This disfacilitation was very effective in counteracting weak stretch components within the random sequence and less effective or even missing when relatively strong stretch components could force the spike elicitation. This led to the reestablishment of phase-locked patterns. The results were discussed in relation to the known encoder models.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00336890
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  • 10
    Electronic Resource
    Electronic Resource
    A study of the encoder properties of muscle-spindle primary afferent fibers by a random noise disturbance of the steady stretch response (1990)
    Springer
    Biological cybernetics 63 (1990), S. 91-97 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract Muscle spindle stretch responses (cat gastrocnemius muscles) were studied when bothsteady stretch andsmall near-threshold random stretch determined the Ia impulse sequence. Statistical properties of the inter-impulse-intervals gave some insight into the Ia encoder mechanism. Superimposed random stretch of mean velocitiesσ vel below 5 mm s−1 did not change the mean discharge rate, but the width of the Ia interspike interval distribution was clearly increased. Raising the stretch velocity further (σ vel 〉 5 mm s−1) led to an additional increase in the distribution width, finally reaching values of 0.6 for the coefficient of variation. The shapes of the impulse interval histograms changed from symmetrical to positively skewed ones. The 1st order serial correlation coefficient of the interval sequence shifted to slightly more negative values with increasingσ vel; on the average, ther 1,2-value varied between zero and −0.2. The data were discussed in relation to current ideas on the mechanism of impulse initiation in the Ia terminal ending. They provide evidence that a combination of multiple encoder sites located in the myelinated terminal branches and a separate pathway for large static and small-amplitude dynamic stretch is not very likely. A model is proposed as to how the whole tree of myelinated axons functions as a single encoder site.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00203030
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