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  • 1
    Electronic Resource
    Electronic Resource
    A proposal for staging malignant melanoma (1983)
    Springer
    Archives of dermatological research 275 (1983), S. 255-256 
    Details
    ISSN: 1432-069X
    Keywords: Malignant melanoma ; Pretherapeutic TNM classification ; Posttherapeutic TNM classification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00416672
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Operative mortality in carcinoma of the rectum (1993)
    Springer
    International journal of colorectal disease 8 (1993), S. 158-166 
    Details
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Une analyse de la mortalité opératoire pour cancer du rectum dans le groupe allemand de cancers colorectaux (SGCRC), comprenant 1115 patients opérés, a trouvé un taux total de mortalité opératoire de 4,3% et un taux de mortalité à 30 jours de 2,8%. L'âge avancé, des maladies associées sévères, une fuite anastomotique dans les résections antérieures et le lieu de traitement ont été trouvés comme étant les facteurs avec une influence significative indépendante. Dans les résections antérieures, spécialement dans les résections antérieures basses, avec entérostomie de protection, les taux les plus bas de fuite anastomotique et de mortalité mettent en évidence les avantages de l'entérostomie de protection.
    Notes: Abstract An analysis of operative mortality for carcinoma of the rectum in the German Study Group Colo-Rectal Carcinoma (SGCRC) comprising 1115 operated patients, found a total operative mortality rate of 4.3% and a 30-day-mortality rate of 2.8%. Advanced age, severe concurrent disease, anastomotic leakage in anterior resections and institution were found to be factors with independent significant influence. In anterior resections, especially low anterior resections, with protective enterostomy, the lower rates of anastomotic leakage and mortality emphasize the advantages of protective enterostomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00341191
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Autoinhibition of noradrenaline release from the rat heart as a function of the biophase concentration. Effects of exogenous α-adrenoceptor agonists, cocaine, and perfusion rate (1984)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 325 (1984), S. 25-33 
    Details
    ISSN: 1432-1912
    Keywords: Rat perfused heart ; 3H-noradrenaline release ; α-Adrenoceptor agonists ; Modulation of autoinhibition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Rat isolated perfused hearts with the right sympathetic nerves intact were loaded with 3H-(-)-noradrenaline. The nerves were stimulated with trains of 180 pulses at 3 Hz and at 10 min intervals. The overflow of 3H-noradrenaline and 3H-metabolites was determined by liquid scintillation spectrometry. 2. Clonidine (IC50 17 nM), oxymetazoline (IC50 63 nM), and α-methylnoradrenaline (apparent IC50 35 nM, determined in the presence of cocaine and propranolol) decreased the stimulation-evoked overflow of 3H-noradrenaline by 26, 49, and 78%, respectively, but not methoxamine up to 100 μM (propranolol present). Oxymetazoline and α-methyl-noradrenaline did not cause desensitization of the presynaptic adrenoceptors when present at their IC80 for 33 min. 3. At a perfusion rate of 7 ml/min, yohimbine 1 μM enhanced the stimulation-evoked 3H-noradrenaline overflow by 26% in the absence, and by 58% in the presence of cocaine. Phentolamine 1 μM increased it by 69% when the neuronal reuptake was blocked. The increase by the antagonists faded with successive periods of nerve stimulations, and was positively correlated with the biophase concentration of noradrenaline as reflected by the amount of 3H-noradrenaline released into the perfusate per nerve stimulation. 4. At a perfusion rate of 1.8 ml/min (neuronal reuptake blocked), yohimbine 1 μM increased the overflow by 127%. 5. The results indicate that the α 2-adrenoceptor-mediated autoinhibition in the rat perfused heart depends on the clearance of transmitter from the biophase via neuronal reuptake and diffusion into the vascular space. Reduction of either elimination pathway enhances the biophase concentration of noradrenaline, thus increasing the autoinhibition of release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00507050
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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