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  • 1
    ISSN: 1432-0568
    Keywords: Corticotropin releasing factor ; Neurosecretion ; Hypophysis ; X-irradiation ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 195 female Wistar rats the influence of adrenalectomy, total body X-irradiation and dexamethasone treatment on the amount of CRF-granules in the external zone of the median eminence and “classical” neurosecretory material (NSM) in the internal zone of the median and in the posterior lobe of the hypophysis has been studied. In the normal rat only very few CRF-granules occur. 15 days after adrenalectomy increased amounts of CRF-granules but normal amounts of “classical” NSM are found. X-irradiation leads to a slight diminishment of “classical” NSM in normal rats. In adrenalectomized animals X-irradiation causes no changes in the amount of “classical” NSM but a marked decrease in the amount of CRF-granules. Application of dexamethasone from the 15th to 18th day after adrenalectomy enhances the augmentation of CRF-granules in irradiated and non-irradiated rats but does not influence the amount of “classical” NSM. The findings show that no correlation exists between the quantitative changes of CRF-granules and “classical” NSM under the experimental conditions used. Therefore it is to be assumed that the release of the two substances is regulated by different control mechanisms and that the substances have a different functional significance. The observations do not exclude the possibility that CRF-granules and “classical” NSM are biochemically identical.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1440
    Keywords: Gated blood pool scintigraphy ; Coronary heart disease ; Ejection fraction ; Volume curves ; Funktionsszintigraphie des Herzens ; Koronare Herzerkrankung ; Auswurffraktion ; max. Volumenänderungsgeschwindigkeit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 43 Patienten mit koronarer Herzerkrankung sowie 24 Patienten, bei denen eine Erkrankung des Herzens ausgeschlossen werden konnte, wurden nach i.v. Injektion von 15mCi99mTc-Humanserum-Albumin mittels eines Gamma-Kamera-Computersystems die Volumenänderungen im Verlauf einer „repräsentativen“ Herzaktion auf nichtinvasivem Wege registriert und quantitativ ausgewertet. Aus der so gewonnenen Volumenänderungskurve des linken Ventrikels wurden die Auswurffraktion sowie die maximale Füllungs- und Entleerungsgeschwindigkeit bestimmt. Bei Patienten mit koronarer Herzerkrankung kam es zu einer signifikanten, schweregradabhängigen Abnahme dieser Parameter, wobei die Veränderung der maximalen Füllungsgeschwindigkeit als Ausdruck einer Herabsetzung der Compliance besonders ausgeprägt war. Das Verfahren erscheint somit zur nichtinvasiven Beurteilung der Funktion des linken Ventrikels geeignet.
    Notes: Summary In 43 patients with angiographically proven coronary heart disease and in 24 patients without heart disease, gated blood pool scintigraphy was done under resting conditions with 15 mCi99mTcHSA in LAO projection. Scintigraphic data were collected in list mode by means of a gamma camera connected to a computer system (Siemens 330). A cumulative scintigram sequence with a time resolution of 100 frames/s was constructed using several hundred heart cycles of equal duration. After background correction volume curves of the left ventricle were obtained and the following parameters were calculated: EF,dV/dt max,dV/dt min. In all patients with coronary heart disease, these parameters were reduced depending on the severity of the stenotic lesion. The changes ofdV/dt min and to a greater extent ofdV/dt max were more pronounced than those of the EF. These results are in keeping with invasively obtained data which show that a decrease of myocardial compliance is one of the earliest manifestations of CHD. Quantitative gated nuclear cardiography allows, therefore, noninvasive evaluation of left ventricular function even under resting conditions.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 49 (1971), S. 494-498 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Drei Untersuchungsmethoden zur Bestimmung des PBJ131 im Serum wurden durch Parallelversuche miteinander verglichen. Diegelchromatographische Trennung von PBJ und Jodid erbrachte die exaktesten Ergebnisse, erforderte jedoch auch den größten Zeit-, Arbeits- und Materialaufwand. DieTrichloressigsäuremethode führte regelmäßig zu höheren, dasIonenaustauschverjahren zu geringeren PBJ-Werten als die Gelchromatographie. Die Inkonstanz der Abweichungen von den Realwerten war bei Trichloressigsäure und Ionenaustauscher etwa gleich groß. Technische Fehler konnten beim Ionenaustauscherverfahren leichter vermieden und besser kontrolliert werden. Es erwies sich zudem als wesentlich schneller und einfacher durchführbar. — Nach den erzielten Ergebnissen ist die Ionenaustauscheranwendung zur PBJ131-Bestimmung alsRoutinemethode in erster Linie in Betracht zu ziehen.
    Notes: Summary Simultaneous testing of three methods for the assessment of131PBI in serum permitted good comparison. Gel chromatographic separation of PBI yielded the most accurate results but required considerably more time and material than the other methods. The use of trichloroacetic acid regulary led to higher, application of an ion exchange resin to lower values when compared with the results of chromatography. The variation from the true values was approximately the same for both trichloroacetic acid and ion exchange resin, which proved, in addition, very much easier and less time-consuming. — It is concluded that the most suitable method for routine work is the one using ion exchange resin.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 55 (1977), S. 911-915 
    ISSN: 1432-1440
    Keywords: Coronary arteriogram ; Myocardial scintigram ; Arrythmias ; Myocarditis ; Small vessel disease ; Koronarogramm ; Myokardszintigramm ; Arrythmien ; Myokarditis ; Small vessel disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 7 Patienten (Durchschnittsalter 42 Jahre) mit Rhythmusstörungen verschiedener Form wurden mit Hilfe der Myokardszintigraphie Verteilungsstörungen der myokardialen Perfusion bei im Koronarogramm unauffälligen extramuralen Koronargefäßen nachgewiesen. Die Defekte waren zum Teil umschrieben, zum Teil diffus. Bei 2 Patienten mit einem Linksschenkelblock projizierte sich die Perfusionsverteilungsstörung auf den oberen Teil des Septum interventriculare. Ein Zusammenhang zwischen der Topographie des Perfusionsdefektes und der Form der elektrophysiologischen Abnormität erscheint bei diesen Patienten wahrscheinlich. Als Ätiologie der myokardialen Perfusionsstörung kann bei einem der Patienten ein Zustand nach Myokarditis mit narbiger Ausheilung angenommen werden. Bei den anderen 6 Patienten muß die Ursache der Perfusionsstörung offen bleiben. Das Vorliegen einer „small vessel disease“ muß diskutiert werden. Die Untersuchungen weisen auf einen Zusammenhang zwischen Störungen im Bereich der Mikrozirkulation und Arrhythmien bei jüngeren Patienten hin.
    Notes: Summary In 7 patients with arrhythmias of various origin the myocardial scintigram displayed either a diffuse or circumscript defect of the perfusion. The coronary arteriogram was normal in all patients. The localized defect of the perfusion in 2 patients was in the region of the upper part of the interventricular septum. Both had a left bundle brunch block. A correlation between the perfusion defect and the electrophysiological abnormality seems probable. The perfusion defect in one of the patients is most probably caused by a previous myocarditis followed by fibrous changes. In the other 6 patients the cause for the perfusion defect is not obvious. A history of myocarditis is missing. The presence of “small vessel disease” in those patients has however to be considered. Our results point to the relation between an abnormality of the microcirculation and arrhythmias in younger patients.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 50 (1972), S. 360-363 
    ISSN: 1432-1440
    Keywords: Blood flow distribution ; computer scintigraphy ; chronic obstructive airways disease ; pulmonary hypertension ; Durchblutungsverteilung ; Computerszintigraphie ; Chronisch obstruktive Atemwegserkrankung ; Pulmonale Hypertonie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 19 Patienten mit obstruktivem Syndrom wurde mit Hilfe der Computerszintigraphie die Verteilung der Lungendurchblutung in den Lungenober- und Lungenunterfeldern bestimmt. Es zeigte sich, daß in signifikanter Korrelation mit zunehmendem Druck in der A. pulmonalis die Oberfclder vermehrt durchblutet werden. Eine Ausnahme bildeten Patienten mit ausgedehnten emphysematösen oder restriktiven Veränderungen. Die Computerszintigraphie bietet die Möglichkeit, durch ein den Patienten nicht belastendes Verfahren, wichtige Hinweise für das Vorliegen einer pulmonalen Hypertonie zu gewinnen.
    Notes: Summary The distribution of blood flow in the lungs was determined in 19 patients with chronic obstructive airways disease. It could be shown that the upper parts of the lungs tend to be more perfused with increasing pulmonary artery pressure. Exceptions are patients with massive emphysematous or restrictive alterations of lung parenchyma in the upper zones of the lungs. The computer scintigraphy provides with information concerning the presence or absence of pulmonary hypertension without great stress to the patient.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 31 (1974), S. 23-38 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Hypotheses, the methodological bases, the use and the results of a new procedure for the preoperative pathological diagnosis of organic brain lesions is described. On the basis of Bayes' theorems concerning the probability estimation of hypotheses, a computer programme was developed which made it possible, based on Incidence Matrices, to ascertain mathematically in a case of abnormal clinical and scintigraphic findings the percentage probability for the consideration of (in the first place) nine different illnesses. As a first step a completed programme in 85 histologically verified cases could be tested and it led, in 88% of these cases, to the correct or essentially correct diagnosis. The further development provided for, as well as future possibilities for, an improvement of this new method were set out.
    Notes: Zusammenfassung Voraussetzungen, methodische Grundlagen, Anwendung und Ergebnisse eines neuen Verfahrens zur präoperativen Artdiagnostik hirnorganischer Prozesse werden beschrieben. Auf der Basis des Bayesschen Theorems zur Wahrscheinlichkeitseinschätzung von Hypothesen wurde ein Computerprogramm entwickelt, das es an Hand von Inzidenzmatrizen ermöglicht, aus den bei einem Fall erhobenen klinischen und szintigraphischen Befunden prozentuale Wahrscheinlichkeiten für das Vorliegen von zunächst neun verschiedenen Erkrankungen rechnerisch zu ermitteln. Das in einer ersten Ausbaustufe fertiggestellte Programm konnte an 85 histologisch verifizierten Fällen erprobt werden und führte in 88% dieser Fälle zu richtigen bzw. fakultativ richtigen Diagnosen. Die vorgesehene Weiterentwicklung sowie zukünftige Möglichkeiten einer Optimierung der neuen Methode werden dargelegt.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 92 (1990), S. 6875-6889 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Liquid helium clusters are produced by expanding gaseous 4 He into a vacuum from a cold source with temperatures between 5 and 20 K at stagnation pressures from P0 =8 to 20 bar and are studied by time-of-flight (TOF) and mass spectrometry. At low temperatures, T0 〈12 K, the mass spectra show several anomalies which can be attributed to pick-up of residual gases. At T0 〈10K, there is evidence for a very intense peak at m=16 amu which is attributed to He+4 . Depending on the temperatures, the TOF spectra reveal ions with three different velocities. These TOF observations are analyzed using isentropic lines in the known phase diagram of 4 He, which take into account deviations from ideal gas behavior. Three qualitatively different expansion regimes are identified: (I) the expansion proceeds through a region on the high temperature side of the critical point, (II) the expansion passes through or near the critical point, and (III) the expansion passes through a region on the low temperature side of the critical point. The mass spectra, peak velocities and speed ratios, when analyzed with the aid of the phase diagram, indicate that (a) two of the TOF peaks are due to clusters, (b) the fastest cluster peak is due to clusters formed by condensation of gas phase atoms, and (c) the slowest cluster peak is due to either separation into two phases (regime II) or disintegration of a liquid phase (regime III). Measured conversions of initial enthalpy into free jet kinetic energy suggest that the cluster temperature undergoes a sharp drop to a very low temperature approaching 0 K at T0 〈6.5 K where the expansion isentrope intersects the liquid–vapor line upstream from the source orifice.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 759 (1995), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    International Journal of Radiation Applications & Instrumentation. Part D, 18 (1991), S. 403-406 
    ISSN: 1359-0189
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Type of Medium: Electronic Resource
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