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  • 1
    Electronic Resource
    Electronic Resource
    Phase I study to the immunotherapy of metastatic malignant melanoma by a cancer vaccine consisting of autologous cancer cells transfected with the human IL-2 gene (1997)
    Springer
    Journal of molecular medicine 75 (1997), S. 297-299 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001090050115
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  • 2
    Electronic Resource
    Electronic Resource
    Über Klinik und Pathologie der isolierten Rundherde der Lungen (1934)
    Springer
    Lung 85 (1934), S. 116-138 
    Details
    ISSN: 1432-1750
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02146919
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  • 3
    Electronic Resource
    Electronic Resource
    Vegetating cicatricial pemphigoid (1987)
    Springer
    Archives of dermatological research 279 (1987), S. S30 
    Details
    ISSN: 1432-069X
    Keywords: Cicatricial pemphigoid ; Vegetating lesions ; Immunopathology ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case with widespread vegetating-pustular skin lesions, oral erosions, ulcerations and scarring, and conjunctival synechiae is reported. Clinically, histopathologically, and by immunofluorescence and electron microscopy this patient combined the features of pemphigoid vegetans, as described by Winkelmann and Su, and the mucocutaneous type of cicatricial pemphigoid. This observation suggests that a third subset of cicatricial pemphigoid can now be added to the two existing ones, the mucocutaneous and Brunsting-Perry types, and the designation vegetating cicatricial pemphigoid is proposed for this heretofore undescribed condition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00585917
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  • 4
    Electronic Resource
    Electronic Resource
    P45, an extracellular 45 kDa protein of Listeria monocytogenes with similarity to protein p60 and exhibiting peptidoglycan lytic activity (2000)
    Springer
    Archives of microbiology 173 (2000), S. 21-28 
    Details
    ISSN: 1432-072X
    Keywords: Key wordsListeria monocytogenes ; Secreted protein ; P45 ; spl gene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A monoclonal antibody obtained by immunization of mice with heat-killed cells of Listeria monocytogenes serotype 4d showed reactivity towards a protein (P45) from L. monocytogenes with an apparent molecular mass of 45 kDa. This protein was detected in the culture supernatant and at the cell surface of L. monocytogenes. Proteins cross-reacting with the monoclonal antibody were present in all Listeria strains investigated, except L. grayi. The structural gene was cloned in Escherichia coli and sequenced. Translation of the gene starts at a TTG initiation codon. The gene was found to code for a protein of 402 amino acid residues with a predicted molecular mass of 42.7 kDa. It has a signal peptide of 27 amino acid residues, resulting in a molecular mass for the mature polypeptide of 39.9 kDa. Protein database searches showed that this protein has 55% similarity and 38% identity to protein p60 of L. monocytogenes and exhibits significant sequence similarities to p54 from Enterococcus faecium and Usp45 from Lactococcus lactis. P45 was shown to have peptidoglycan lytic activity and the encoding gene was named spl (secreted protein with lytic property).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002030050003
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  • 5
    Electronic Resource
    Electronic Resource
    Steady-state pharmacokinetics of methadone in opioid addicts (1993)
    Springer
    European journal of clinical pharmacology 44 (1993), S. 189-194 
    Details
    ISSN: 1432-1041
    Keywords: Opioid addicts ; Methadone maintenance ; steady-state pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Kinetic parameters were investigated in tolerant methadone maintenance patients. The disposition of methadone at steady-state was assessed on 8 occasions — in 5 opioid addicts prescribed wide ranging doses of methadone (10 mg to 60 mg per day) — providing unique pharmacokinetic data. Statistical analysis showed that the kinetics of oral methadone at steady-state were described using a single compartment model. Analysis of the plasma concentration-time curves gave estimates of the variance of methadone clearance and apparent volume of distribution, and indicate that methadone is rapidly absorbed (mean Ka, 1.7 h−1) with a detectable increase in the plasma drug concentration 15 to 30 min after dosing. The elimination of methadone from plasma was found to occur slowly (mean t1/2 26.8 h) beginning soon after the administration of the daily oral prescription. The apparent volume of distribution — assuming the oral bioavailability (f) of methadone to be 0.95 — was large (mean 6.71 · kg−1). The slow clearance of this drug from the body (mean 3.1 ml · min−1 · kg−1) confirms that daily dosing at steady-state is adequate to maintain effective plasma concentrations throughout the dosing interval.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315479
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  • 6
    Electronic Resource
    Electronic Resource
    Lactate compared with pH analysis at fetal scalp blood sampling: a prospective randomised study (1998)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 105 (1998), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective Fetal scalp blood sampling is a widely used method for assessing fetal condition in the event of ominous fetal heart rate patterns. The purpose of this randomised trial was to compare the value of fetal scalp blood lactate and pH management in cases of abnormal intrapartum fetal heart rate tracings.Methods Of 341 cases of ominous fetal heart rate patterns, 169 were randomly assigned to pH analysis, and 172 to lactate measurements. Lactate was measured using a lactate card requiring 5 μL of blood and yielding the result within 60 seconds. pH analysis was performed with an ABL 510 acid-base analyser requiring 35 μL of blood and yielding the results within 47 seconds.Results Unsuccessful fetal blood sampling procedures (no result or an unreliable result) occurred significantly more often in the pH subgroup than in the lactate subgroup (OR 16.1 with 95% CI 5.8-44.7). In the pH subgroup the failure rate was inversely related to the degree of cervical dilatation. Compared with the pH subgroup, the lactate subgroup was characterised by fewer fetal scalp incisions per blood sampling attempt (median 1.0 [interquartile range (IQR) 1-11 vs 2.0 [IQR 1-21]), and significantly less time required for the sampling procedure (median 120 s [IQR 90-147] vs 230 s [IQR 180-3001). The groups did not differ in mode of delivery, neonatal outcome and umbilical artery acid–base balance and lactate levels.Conclusion This trial showed the levels of lactate and pH in fetal scalp blood to be comparable in predicting perinatal outcome, but the procedure to measuring lactate was more successful than that for pH. Owing to its simplicity of performance, lactate analysis is an attractive alternative for intrapartum fetal monitoring.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1998.tb09346.x
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  • 7
    Electronic Resource
    Electronic Resource
    Multipoint Mapping of the Central Core Disease Locus
    Amsterdam : Elsevier
    Genomics 17 (1993), S. 205-207 
    Details
    ISSN: 0888-7543
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1006/geno.1993.1302
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  • 8
    Electronic Resource
    Electronic Resource
    Use of 'very low-dose phenobarbital' to investigate compliance in patients on reducing doses of methadone (detoxification)
    Amsterdam : Elsevier
    Journal of Substance Abuse Treatment 10 (1993), S. 453-458 
    Details
    ISSN: 0740-5472
    Keywords: detoxification ; methadone compliance ; pharmacological marker
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0740-5472(93)90006-N
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  • 9
    Electronic Resource
    Electronic Resource
    A review of biological indicators of illicit drug use, practical considerations and clinical usefulness (1999)
    Oxford, UK : Carfax Publishing, Taylor & Francis Ltd
    Addiction 94 (1999), S. 0 
    Details
    ISSN: 1360-0443
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Aims. To examine a range of biological indicators of illicit drug use, including blood, urine, hair and saliva, addressing both technological and practical issues relating to their application and interpretation. Methods. The review process involved an examination of key reference texts and literature from the scientific fields of analytical and clinical toxicology. Findings. Urine remains the biological tool of choice for qualitative detection of illicit drug use in a clinical setting, while quantitative accuracy remains strictly the domain of blood. The growing sophistication of laboratory analysis may additionally make possible the routine use of hair sampling which can provide a much longer time frame for assessment. Breath, saliva, sweat or breast milk remain possibilities in the future. Conclusions. Accurate interpretation of the screening tests within a clinical setting alongside other relevant information remains the key to the usefulness of any test.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1360-0443.1999.94912792.x
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  • 10
    Electronic Resource
    Electronic Resource
    Population-based pharmacokinetic approach for methadone monitoring of opiate addicts: potential clinical utility (2000)
    Oxford, UK : Carfax Publishing, part of the Taylor & Francis Group
    Addiction 95 (2000), S. 0 
    Details
    ISSN: 1360-0443
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Aims. There is evidence that plasma methadone measurements may be of benefit in dosage adjustment during methadone maintenance treatment for opiate dependence. However, to date the kinetics of oral rac-methadone have been poorly characterized. We describe plasma methadone concentration-time data collected from 35 opiate addicts. Subjects. Oral doses of rac-methadone were given to 24 male and 11 female addicts attending a community-based drug treatment centre. Measurements. Plasma methadone concentrations were measured by liquid chromatography (HPLC). Procedures. Plasma concentration-time data were collected from patients prescribed oral rac-methadone in order to describe the complex kinetics of the drug incorporating its long elimination half-life. Findings. Auto-induction of methadone metabolism was demonstrated and it was observed that clearance of methadone was significantly lower (p 〈 0.05) in opiate addicts at the start of treatment (median elimination half-life, 128-hours) than in those who had reached steady-state (median elimination half-life, 48 hours). Our data has provided the basis for a population-based pharmacokinetic (POP-PK) model which is intended for use as a clinical tool in association with plasma measurements in methadone maintenance patients. Conclusions. Using plasma monitoring in combination with the application of Bayesian forecasting it should be possible to predict trough levels of methadone during daily dosing. The model is able to utilize sparse sampling, and two blood samples are expected to be sufficient to define patient compliance. Random samples during treatment could be used to assess methadone dosing by comparing predicted with observed measurements for each individual. The clinical tool could therefore help to detect incomplete (failure to consume the whole daily dose as prescribed) and poor (due to ingestion of extra illicit methadone) compliance as well as therapeutic failure due to drug-drug interactions. Targeting resources in this way could be a cost-effective tool for supervision of methadone dosing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1360-0443.2000.951217717.x
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