Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Studies on cutaneous vascular permeability in the rat: Increases caused by histamine and histamine-like agents (1984)
    Springer
    Inflammation research 14 (1984), S. 39-42 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The pharmacology of histamine-induced increases in microvascular permeability has been studied in rat skin. Histamine caused dose-dependent increases in microvascular permeability, assessed as increases in extravascular albumin accumulation. The responses to histamine were inhibited in a dose-dependent manner by pretreatment with mepyramine and were not changed by cimetidine. 2-(2-Aminoethyl)pyridine also increased microvascular permeability whereas impromidine did not. These results suggest that H1-receptors and not H2-receptors are involved in the permeability response to histamine in rat skin. In contrast, dimaprit increased microvascular permeability and responses to dimaprit exceeded the maximum response to histamine. The response to dimaprit proved to be independent of H2 receptors and was consistent with an indirect response due to mast cell degranulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01966830
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Histamine H1- and H2-receptor involvement in eosinophil infiltration and the microvascular changes associated with cutanneous anaphylaxis (1985)
    Springer
    Inflammation research 17 (1985), S. 121-125 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Several substances alter eosinophil motility, but the relative importance of these putative mediators in immediate hypersensitivity remains unclear. The present study has reinvestigated the role of histamine in type I allergic eosinophil infiltration, and the temporally associated microvascular events, by examining the effect of H1-and H2-receptor antagonist pretreatment. A combination of cimetidine and pyrilamine significantly reduced eosinophil accumulation, whereas neither antagonist alone was effective. Similarly, cutaneous hyperemia, measured indirectly as ear surface temperature, was reduced only by the cimetidine-pyrilamine combination. Pyrilamine partially attenuated the increase in microvascular permeability, but the addition of cimetidine provided no further reduction. It appears that histamine participates significantly in mediating both the microvascular changes and the eosinophil infiltration evoked by cutaneous anaphylaxis. The histaminergic component of increased microvascular permeability appears to be an H1-receptor mediated phenomenon. However, blockade of both H1-and H2-receptor subtypes is required to inhibit the hyperemia and eosinophil infiltration responses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01966579
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Bimatoprost: A Novel Antiglaucoma Agent (2004)
    Oxford, UK : Blackwell Publishing Ltd
    Cardiovascular drug reviews 22 (2004), S. 0 
    Details
    ISSN: 1527-3466
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim of glaucoma therapy is to preserve vision by reducing intraocular pressure (IOP). Following recent National Eye Institute sponsored studies, it is becoming increasingly apparent that every mmHg of extra IOP lowering counts.Bimatoprost is the newest and most effective addition to the physician's armamentarium of ocular hypotensive drugs. Direct clinical comparisons have demonstrated that it is more efficacious than the prostaglandin (PG) FP receptor agonist prodrugs, latanoprost and travoprost, as well as a β-adrenoceptor antagonist, timolol, alone or in fixed combination with the carbonic anhydrase inhibitor, dorzolamide. Moreover, patients that are refractory to latanoprost therapy may be successfully treated with bimatoprost. Such evidence provides support, at the clinical level, for the contention that bimatoprost is pharmacologically distinct from PG FP receptor agonist prodrugs.Bimatoprost is a structural analog of PGF2α-ethanolamide (prostamide F2α), which is formed from the endocannabinoid anandamide by a biosynthetic pathway involving cyclooxygenase-2 (COX-2). Their pharmacology is remarkably similar, such that bimatoprost may be regarded as a prostamide mimetic. The target receptor for bimatoprost and the prostamides appears unique and unrelated to PG- and endocannabinoid-sensitive receptors. Extensive ocular distribution/metabolism studies in non-human primates demonstrate that bimatoprost is not a prodrug, it remains essentially intact. Its profound ocular hypotensive effects may, therefore, be attributed to its prostamide-mimetic properties.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1527-3466.2004.tb00134.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Distribution of metals during digestion by cutthroat trout fed benthic invertebrates contaminated in the Clark Fork River, Montana and the Coeur d'Alene River, Idaho, U.S.A., and fed artificially contaminated Artemia (2000)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 56 (2000), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The concentrations of essential amino acids in three, undigested invertebrate diets collected from the Clark Fork River (CFR) for cutthroat trout were similar to each other, but were c. 25–75% less than Artemia that were exposed to a mixture of arsenic, copper, cadmium, lead and zinc in the laboratory. The Artemia diet appeared less palatable and the texture, quantity and appearance of the intestinal contents differed between fish fed the Artemia and CFR diets. The Pb% in the fluid fraction of the intestinal contents was greater for the Artemia (29%) than for the CFR diets (10–17%), and the Cu% in the amino acid plus metal fraction of the intestinal contents was greater for the Artemia (78%) than for two of the three CFR diets (67% and 70%). Intestinal contents of fish fed invertebrate diets collected from various sites on the Coeur d'Alene River (CDA), Idaho, were similar in texture, quantity, and appearance. For fish fed the CDA diets, differences in the distribution of metals among fractions of the digestive fluids appeared to be related to concentrations of metals in the invertebrate diets. Pb% was lowest of all metals in the fluid portion of the intestinal contents. However, 〉80% of all metals in the hind gut were associated with the particulate fraction where they may still be available for uptake through pinocytosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.2000.tb02093.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Toxicity of five forest insecticides to cutthroat trout and two species of aquatic invertebrates (1980)
    Springer
    Bulletin of environmental contamination and toxicology 25 (1980), S. 846-854 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01985619
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Petroleum hydrocarbon concentrations in a salmonid stream contaminated by oil field discharge water and effects on macrobenthos (1983)
    Springer
    Archives of environmental contamination and toxicology 12 (1983), S. 327-334 
    Details
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract The concentration of total hydrocarbons in the water effluent from an oil field was 5.6 mg/L and resulted in concentrations of 46 to 85μg/L in the receiving stream. Total hydrocarbons were 55,000 times more concentrated in the sediment than in the water, ranging from 979 (778) to 2,515 (1,263) mg/kg. Saturated hydrocarbons contributed most to the total hydrocarbon concentration in both water and sediment. Naphthalenes were found in stream water, but not in sediment. Cadmium, chromium, copper, lead, and zinc were detected in water and sediment. Zinc was elevated in the sediment, probably because an organic zinc complex was used by the oil company during processing to enhance oil-water separation. Species diversity of macrobenthos was reduced below the discharge, as evidenced by the almost complete elimination of Plecoptera and Trichoptera. Shannon-Weaver diversity index values ranged from 3.4 at the upstream control station to 1.2 to 1.7 below the oil field effluent. The representation of Diptera increased from 10% of the total insects at the least polluted station to 46% at the station containing the most dissolved hydrocarbons. On the basis of our findings, discharge of oil into fresh water should be closely regulated to prevent the development of concentrations in water and sediment of the receiving stream that would alter the structure of macrobenthos communities and thereby threaten the fishery resources.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01059410
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Concentrations of Metals Associated with Mining Waste in Sediments, Biofilm, Benthic Macroinvertebrates, and Fish from the Coeur d'Alene River Basin, Idaho (1998)
    Springer
    Archives of environmental contamination and toxicology 34 (1998), S. 119-127 
    Details
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract. Arsenic, Cd, Cu, Pb, Hg, and Zn were measured in sediments, biofilm, benthic macroinvertebrates, and fish from the Coeur d'Alene (CDA) River to characterize the pathway of metals transfer between these components. Metals enter the CDA Basin via tributaries where mining activities have occurred. In general, the ranking of food-web components from the greatest to smallest concentrations of metals was as follows: biofilm (the layer of abiotic and biotic material on rock surfaces) and sediments 〉 invertebrates 〉 whole fish. Elevated Pb was documented in invertebrates, and elevated Cd and Zn were documented in sediment and biofilm approximately 80 km downstream to the Spokane River. The accumulation of metals in invertebrates was dependent on functional feeding group and shredders-scrapers that feed on biofilm accumulated the largest concentrations of metals. Although the absolute concentrations of metals were the largest in biofilm and sediments, the metals have accumulated in fish approximately 50 km downstream from Kellogg, near the town of Harrison. While metals do not biomagnify between trophic levels, the metals in the CDA Basin are bioavailable and do biotransfer. Trout less than 100 mm long feed exclusively on small invertebrates, and small invertebrates accumulate greater concentrations of metals than large invertebrates. Therefore, early-lifestage fish may be exposed to a larger dose of metals than adults.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002449900295
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Accumulation, sublethal effects, and safe concentration of a refined oil as evaluated with cutthroat trout (1983)
    Springer
    Archives of environmental contamination and toxicology 12 (1983), S. 455-464 
    Details
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract Cutthroat trout (Salmo clarki) were exposed for 90 days in the laboratory to a refined oil collected from the North Platte River at a seepage site below the American Oil Company refinery at Casper, Wyoming. Fish were exposed to five concentrations and a control, and seven biological responses (survival, growth, gill pathology, liver pathology, caudal fin erosion, caudal fin pathology and swimming performance) were correlated with water concentration and tissue accumulation of petroleum hydrocarbons. Fish in the highest water concentration, 183μg/L total oil, accumulated tissue concentrations of 4.6μg/g total naphthalenes and responded adversely to all seven biological measurements. Cutthroat trout in the lowest water concentration, 24μg/L total oil, had a mean tissue concentration of 1.2μg/g total naphthalenes, but their response was similar to that of the control fish to all seven biological responses. Fish exposed to 39μg/L water concentration accumulated tissue concentrations of 2.7μg/g and responded negatively to 2 of the 7 biological measurements. Therefore, the maximum safe limit for this oil and cutthroat trout is between 24 and 39μg/L.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01057589
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Histamine-induced microvascular permeability increases in hamster skin: a response predominantly mediated by H2-receptors (1986)
    Springer
    Inflammation research 18 (1986), S. 504-507 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The pharmacology of histamine-induced increases in cutaneous microvascular permeability was investigated in the hamster by (a) examining the effects of cimetidine and pyrilamine on the increase in microvascular permeability evoked by graded doses of intradermally-injected histamine, and (b) comparing the cutaneous microvascular permeability responses to graded doses of impromidine (0.1–100 μg), dimaprit (1–100 μg) and β-histine (0.1–100 μg). Pretreatment with pyrilamine (0.1 mg/kg i.v. bolus injection) did not reduce the increase in microvascular permeability produced by any dose of histamine. In contrast, cimetidine (0.5 mg/kg/min i.v. infusion) significantly inhibited the microvascular permeability responses to 10 and 100 μg histamine. Although neither cimetidine nor pyrilamine significantly altered the microvascular permeability response to 0.1 and 1μg histamine, inhibition was afforded by a cimetidine-pyrilamine combination. These results suggest a predominantly H2-receptor mediated phenomenon with a minor H1-receptor mediated component. Studies with the H2-receptor agonists impromidine and dimaprit and the H1-receptor agonist β-histine provide further support for this contention. Dimaprit and impromidine caused a dose-dependent increase in cutaneous microvascular permeability, but betahistine produced only a relatively modest response. In other laboratory species, increased cutaneous microvascular permeability appears to be mediated solely by H1-receptors. Therefore, the hamster skin appears unique with respect to the pronounced H2-receptor involvement in histamine-induced microvascular permeability changes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01964954
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Histamine involvement in the local and systemic microvascular effects produced by intradermal substance P (1985)
    Springer
    Inflammation research 17 (1985), S. 126-130 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The cutaneous microvascular changes produced by intradermal substance P were quantitatively evaluated in both substance P-injected and contralateral, saline-injected guinea pig ears. Substance P evoked a dose-dependent increase in cutaneous microvascular permeability in both treated and untreated ears which was reduced, but not abolished, by a mepyramine-cimetidine combination. This indicates that the local effect of substance P on microvascular permeability and the effect on the contralateral ear (presumably the result of systemic substance P absorption) are both partially mediated by histamine. A cutaneous vasodilator response was also observed in substance P treated and contralateral ears, but a bell-shaped dose-response relationship was apparent. Unlike microvascular permeability, pretreatment with mepyramine and cimetidine failed to consistently attenuate the vasodilator response to substance P. Thus, a direct cutaneous vasodilator effect appars to predominate in both substance P-injected and saline-injected ears.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01966580
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...