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  • 1
    Electronic Resource
    Electronic Resource
    Carbon Monoxide Hydrogenation on the Ru(001) Surface at Low Temperature Using Gas-Phase Atomic Hydrogen: Spectroscopic Evidence for the Carbonyl Insertion Mechanism on a Transition Metal Surface (1995)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 117 (1995), S. 2606-2617 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00114a025
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Hydrogenation of carbon monoxide at 100 K on the ruthenium(001) surface: spectroscopic identification of formyl intermediates (1993)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 115 (1993), S. 4381-4382 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00063a074
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  • 3
    Electronic Resource
    Electronic Resource
    Mechano-Active Cartilage Tissue Engineering (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Advances in science and technology Vol. 49 (Oct. 2006), p. 189-196 
    Details
    ISSN: 1662-0356
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Natural Sciences in General , Technology
    Notes: To engineer cartilaginous constructs with a mechano-active scaffold and dynamiccompression was performed for effective cartilage tissue engineering. Mechano-active scaffolds werefabricated from very elastic poly(L-lactide-co-ε-carprolactone)(5:5). The scaffolds with 85 %porosity and 300~500 μm pore size were prepared by a gel-pressing method. The scaffolds wereseeded with chondrocytes and the continuous compressive deformation of 5% strain was applied tocell-polymer constructs with 0.1Hz to evaluate for the effect of dynamic compression forregeneration of cartilage. Also, the chondrocytes-seeded constructs stimulated by the continuouscompressive deformation of 5% strain with 0.1Hz for 10 days and 24 days respectively wereimplanted in nude mice subcutaneously to investigate their biocompatibility and cartilage formation.From biochemical analyses, chondrogenic differentiation was sustained and enhanced significantlyand chondrial extracellular matrix was increased through mechanical stimulation. Histologicalanalysis showed that implants stimulated mechanically formed mature and well-developedcartilaginous tissue, as evidenced by chondrocytes within lacunae. Masson’s trichrome and SafraninO staining indicated an abundant accumulation of collagens and GAGs. Also, ECM in constructs wasstrongly immuno-stained with anti-rabbit collagen type II antibody. Consequently, the periodicapplication of dynamic compression can improve the quality of cartilaginous tissue formed in vitroand in vivo
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/42/transtech_doi~10.4028%252Fwww.scientific.net%252FAST.49.189.pdf
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  • 4
    Electronic Resource
    Electronic Resource
    Mechano-Active Cartilage Tissue Engineering: The Effect of Dynamic Compressive Stimulation (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 342-343 (July 2007), p. 409-412 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Mechano-active scaffolds were fabricated from very elasticpoly(lactide-co-carprolactone) by a gel-pressing method. The scaffolds were seeded with bonemarrow stromal cells and the continuous compressive deformation was applied to cell-polymerconstructs in the chondrogenic media. Then, they were implanted in nude mice subcutaneously toevaluate for the effect of dynamic compression for regeneration of cartilage. From the biochemicalanalyses, chondrogenic differentiation was sustained and enhanced significantly and chondralextracellular matrix was increased through mechanical stimulation. Histological analyses showedthat implants stimulated mechanically formed mature and well-developed cartilaginous tissue, asevidenced by bone marrow derived chondrocytes within lacunae. Consequently, the periodicapplication of dynamic compression can encourage bone marrow stromal cells to differentiation tochondrogenic lineage and to maintain their phenotypes
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.409.pdf
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  • 5
    Electronic Resource
    Electronic Resource
    Numerical Simulation of Gas-Solid Flow in a Precalciner of Cement Industry (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 575-578 (Apr. 2008), p. 1234-1239 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Precalciner, in which endothermic raw meal calcination and exothermic fuel combustionproceed simultaneously, is a key equipment in dry process of cement production. To increase theprecalcination degree and reduce the energy consumption, more and more attentions have been paidon modeling gas-solid flow field in precalciners. However, most of them aimed at just qualitativestudies lacking in necessary further quantitative analysis of precalciner performance parameters. Inthis paper, combining qualitative studies and quantitative analysis, the gas-solid flow field wascarried out aiming at an actual precalciner under operational-based boundary conditions. In Eulercoordinate system the gas phase is expressed with k-ε model, in Lagrange coordinate system the solidphase is expressed with Discrete Phase Model(DPM), and the random effects of turbulence on theparticle dispersion is accounted for with Discrete Random Walk (DRW) model. The predicted gasvelocity field agrees well with the measured result, and the calculated raw meal concentrationdistribution is consistent with the actul condition. The results predicted that there is a simplespraying-liked flow field in the precalciner, with not only a non-uniform particle dispersion conditionbut also a low solid residence-time and residence-time ratio between solid and gas
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/18/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.575-578.1234.pdf
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  • 6
    Electronic Resource
    Electronic Resource
    Atomic hydrogen-induced decomposition of chemisorbed formate at 100 K on the Ru(001) surface (1994)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 101 (1994), S. 9195-9197 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Atomic hydrogen-induced C–O bond cleavage in chemisorbed formate on the Ru(001) surface has been investigated with high-resolution electron energy loss spectroscopy. The chemisorbed formate reacts at 100 K with gas-phase atomic hydrogen to produce chemisorbed formyls (η1-HCO and η2-HCO) and hydroxyls, and the hydroxyls react further with the impinging hydrogen to produce adsorbed water. The observation of these "direct'' surface reactions provides strong support for a "coupled'' reaction mechanism, postulated previously, in which hydrogen from C–H bond cleavage in one formate (which produces CO2) reacts with an adjacent formate to form HCO and OH, resulting in a CO to CO2 ratio of unity in the overall thermal decomposition reaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.468047
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  • 7
    Electronic Resource
    Electronic Resource
    The NC2 repressor is dispensable in yeast mutated for the Sin4p component of the holoenzyme and plays roles similar to Mot1p in vivo (2000)
    Oxford, UK : Blackwell Science Ltd
    Molecular microbiology 36 (2000), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: NC2 (Dr1/DRAP1) and Mot1p are global repressors of transcription that have been isolated in both Saccharomyces cerevisiae and humans. NC2 is a dimeric histone-fold complex that represses RNA polymerase II transcription through binding to TBP and inhibition of TFIIA and TFIIB. Mot1p is an ATPase that removes DNA-bound TBP upon ATP hydrolysis. In this work, we studied the core promoter specificity of NC2 in vivo using a strain that carries mutated NC2β activity. We show that NC2, like Mot1p, is required for transcription of the HIS3 and HIS4 TATA-less core promoters. Furthermore, whereas neither Mot1p nor NC2 appear to function as repressors of the HIS3 gene in cells growing exponentially in glucose, we find that both are required for repression of the HIS3 TATA promoter when cells go through the diauxic shift. Thus, the activity of these factors is similarly regulated depending upon the physiological conditions, and it appears that core promoters activated or repressed by them in vivo might be distinguishable by whether or not they contain a canonical TATA sequence. Finally, although NC2 is an essential factor for yeast viability, we isolated a mutation in a non-essential component of the holoenzyme, Sin4p, that bypasses the requirement for NC2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2958.2000.01839.x
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  • 8
    Electronic Resource
    Electronic Resource
    RNAi knockdown of Par-4 inhibits neurosynaptic degeneration in ALS-linked mice (2005)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 92 (2005), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Evidence from human amyotrophic lateral sclerosis (ALS) patients and ALS-linked Cu/Zn superoxide dismutase (Cu/Zn-SOD) transgenic mice bearing the mutation of glycine to alanine at position 93 (G93A) suggests that the pro-apoptotic protein prostate apoptosis response-4 (Par-4) might be a critical link in the chain of events leading to motor neuron degeneration. We now report that Par-4 is enriched in synaptosomes and post-synaptic density from the ventral horn of the spinal cord. Levels of Par-4 in synaptic compartments increased significantly during rapid and slow declining stages of muscle strength in hSOD1 G93A mutant mice. In the pre-muscle weakness stage, hSOD1 G93A mutation sensitized synaptosomes from the ventral horn of the spinal cord to increased levels of Par-4 expression following excitotoxic and apoptotic insults. In ventral spinal synaptosomes, Par-4-mediated production of pro-apoptotic cytosolic factor(s) was significantly enhanced by the hSOD1 G93A mutation. RNA interference (RNAi) knockdown of Par-4 inhibited mitochondrial dysfunction and caspase-3 activation induced by G93A mutation in synaptosomes from the ventral horn of the spinal cord, and protected spinal motor neurons from apoptosis. These results identify the synapse as a crucial cellular site for the cell death promoting actions of Par-4 in motor neurons, and suggest that targeted inhibition of Par-4 by RNAi may prove to be a neuroprotective strategy for motor neuron degeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.2004.02834.x
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  • 9
    Electronic Resource
    Electronic Resource
    Improved control and data-acquisition electronics for high-resolution electron energy loss spectroscopy (1996)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 67 (1996), S. 710-714 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A new version of low-noise, high-stability control, data-acquisition electronics has been designed and constructed for high-resolution electron energy loss spectroscopy to meet the requirements imposed by new digital signal processing techniques. The improved electronics feature fast, low-noise, high-stability, programable voltage sources with 16 bit precision for the electron optics and a custom-built 16 bit 100 MHz pulse counter. These electronics, controlled by an IBM-compatible PC through a user-friendly, graphical software interface, allow easy computerized tuning and spectral recording. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1146847
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  • 10
    Electronic Resource
    Electronic Resource
    Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease (1998)
    [s.l.] : Nature Publishing Group
    Nature medicine 4 (1998), S. 957-962 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Prostate apoptosis response-4 (Par-4) is a protein containing both a leucine zipper and a death domain that was isolated by differential screening for genes upreguiated in prostate cancer cells undergoing apoptosis1,2. Par-4 is expressed in the nervous system3, where its function is unknown. In ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm0898-957
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