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  • 1
    ISSN: 0003-2670
    Keywords: Amperometry ; Electrophoresis ; Hydrazines
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 116 (1994), S. 2821-2826 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1420-9136
    Keywords: Qinghai-Xizang (Tibetan) plateau ; source process ; moment tensor ; tectonic stress field
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract TheM s =6.9 Gonghe, China, earthquake of April 26, 1990 is the largest earthquake to have been documented historically as well as recorded instrumentally in the northeastern Qinghai-Xizang (Tibetan) plateau. The source process of this earthquake and the tectonic stress field in the northeastern Qinghai-Xizang plateau are investigated using geodetic and seismic data. The leveling data are used to invert the focal mechanism, the shape of the slipped region and the slip distribution on the fault plane. It is obtained through inversion of the leveling data that this earthquake was caused by a mainly reverse dip-slipping buried fault with strike 102°, dip 46° to SSW, rake 86° and a seismic moment of 9,4×1018 Nm. The stress drop, strain and energy released for this earthquake are estimated to be 4.9 MPa, 7.4×10−5 and 7.0×1014 J, respectively. The slip distributes in a region slightly deep from NWW to SEE, with two nuclei, i.e., knots with highly concentrated slip, located in a shallower depth in the NWW and a deeper depth in the SEE, respectively. Broadband body waves data recorded by the China Digital Seismograph Network (CDSN) for the Gonghe earthquake are used to retrieve the source process of the earthquakes. It is found through moment-tensor inversion that theM s =6.9 main shock is a complex rupture process dominated by shear faulting with scalar seismic moment of the best double-couple of 9.4×1018 Nm, which is identical to the seismic moment determined from leveling data. The moment rate tensor functions reveal that this earthquake consists of three consecutive events. The first event, with a scalar seismic moment of 4.7×1018 Nm, occurred between 0–12 s, and has a focal mechanism similar to that inverted from leveling data. The second event, with a smaller seismic moment of 2.1×1018 Nm, occurred between 12–31 s, and has a variable focal mechanism. The third event, with a sealar seismic moment of 2.5×1018 Nm, occurred between 31–41 s, and has a focal mechanism similar to that inverted from leveling data. The strike of the 1990 Gonghe earthquake, and the significantly reverse dip-slip with minor left-lateral strike-slip motion suggest that the pressure axis of the tectonic stress field in the northeastern Qinghai-Xizang plateau is close to horizontal and oriented NNE to SSW, consistent with the relative collision motion between the Indian and Eurasian plates. The predominant thrust mechanism and the complexity in the tempo-spatial rupture process of the Gonghe earthquake, as revealed by the geodetic and seismic data, is generally consistent with the overall distribution of isoseismals, aftershock seismicity and the geometry of intersecting faults structure in the Gonghe basin of the northeastern Qinghai-Xizang plateau.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Pure and applied geophysics 155 (1999), S. 1-32 
    ISSN: 1420-9136
    Keywords: Key words: COAMPS, coupled model, mutual response, tropical squall line, atmosphere, ocean, heat fluxes.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract —The Coupled Ocean/Atmosphere Mesoscale Prediction System (COAMPS) is used to investigate the mutual response of a tropical squall line and the ocean. Simulated squall line compares well with the observations, and consists of counterrotating vortices, and has a bow shape bulge toward the leading edge. In addition to these features, which are also shown in the previous numerical simulations, the unique results from the coupled simulation indicate that the air–sea interaction processes within the squall line are important. They affect both the atmosphere and the ocean locally. Simulated upper ocean displays significant response to the squall line with upwelling and baroclinicity. Depth of the ocean mixed layer in the coupled simulation becomes modified due to feedback processes. Ocean temperature acts as a destabilizing factor, and the salinity as a stabilizing factor. Surface turbulent fluxes from the coupled simulation are about 10% less than that of the uncoupled simulation. The SST in the coupled simulation decreases by about 0.21°C. Predicted squall line in the coupled simulation is weaker as compared to the uncoupled simulation. This is reflected in terms of differences in surface fluxes, cloud water, rain water and vertical velocities between the two simulations.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    The journal of membrane biology 143 (1995), S. 79-87 
    ISSN: 1432-1424
    Keywords: Pancreatic beta-cell ; Islet of Langerhans ; Voltage clamp ; Gap junctions ; Electrotonic coupling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The quantitative characterization of ion channel properties in pancreatic β-cells under typical patch clamp conditions can be questioned because of the unreconciled differences in experimental conditions and observed behavior between microelectrode recordings of membrane potential in intact islets of Langerhans and patch recordings of single cells. Complex bursting is reliably observed in islets but not in isolated cells under patch clamp conditions. E. Rojas et al. (J. Membrane Biol. 143:65–77, 1995) have attempted to circumvent these incompatibilities by measuring currents in β-cells in intact islets by voltage-clamping with intracellular microelectrodes (150–250 MΩ tip resistance). The major potential pitfall is that β-cells within the islet are electrically coupled, and contaminating coupling currents must be subtracted from current measurements, just as linear leak currents are typically subtracted. To characterize the conditions under which such coupling current subtraction is valid, we have conducted a computational study of a model islet. Assuming that the impaled cell is well clamped, we calculate the native and coupling components of the observed current. Our simulations illustrate that coupling can be reliably subtracted when neighbor cells' potentials are constant or vary only slowly (e.g., during their silent phases) but not when they vary rapidly (e.g., during their active phases). We also show how to estimate coupling conductances in the intact islet from measurements of coupling currents.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    The journal of membrane biology 164 (1998), S. 139-153 
    ISSN: 1432-1424
    Keywords: Key words: Ion channels — Adrenal — Lanthanide — Potassium channel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract. The modulation of I A K+ current by ten trivalent lanthanide (Ln3+) cations spanning the series with ionic radii ranging from 0.99 Å to 1.14 Å was characterized by the whole-cell patch clamp technique in bovine adrenal zona fasciculata (AZF) cells. Each of the ten Ln3+s reduced I A amplitude measured at +20 mV in a concentration-dependent manner. Smaller Ln3+s were the most potent and half-maximally effective concentrations (EC50s) varied inversely with ionic radius for the larger elements. Estimation of EC50s yielded the following potency sequence: Lu3+ (EC50= 3.0 μm) ≈ Yb3+ (EC50= 2.7 μm) 〉 Er3+ (EC50= 3.7 μm) ≥ Dy3+ (EC50= 4.7 μm) 〉 Gd3+ (EC50= 6.7 μm) ≈ Sm3+ (EC50= 6.9 μm) 〉 Nd3+ (EC50= 11.2 μm) 〉 Pr3+ (EC50= 22.3 μm) 〉 Ce3+ (EC50= 28.0 μm) 〉 La3+ (EC50= 33.7 μm). Ln3+s altered selected voltage-dependent gating and kinetic parameters of I A with a potency and order of effectiveness that paralleled the reduction of I A amplitude. Ln3+s markedly slowed activation kinetics and shifted the voltage-dependence of I A gating such that activation and steady-state inactivation occurred at more depolarized potentials. In contrast, Ln3+s did not measurably alter inactivation or deactivation kinetics and only slightly slowed kinetics of inactivated channels returning to the closed state. Replacement of external Ca2+ with Mg2+ had no effect on the concentration-dependent inhibition of I A by Ln3+s. In contrast to their action on I A K+ current, Ln3+s inhibited T-type Ca2+ currents in AZF cells without slowing activation kinetics. These results indicate that Ln3+ modulate I A K+ channels through binding to a site on I A channels located within the electric field but which is not specific for Ca2+. They are consistent with a model where Ln3+ binding to negative charges on the gating apparatus alters the voltage-dependence and kinetics of channel opening. Ln3+s modulate transient K+ and Ca2+ currents by two fundamentally different mechanisms.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    The journal of membrane biology 169 (1999), S. 189-198 
    ISSN: 1432-1424
    Keywords: Key words: Ca2+ release channel — Ryanodine receptor — Sarcoplasmic reticulum — 2,3-butanedione 2-monoxime — Skeletal muscle — Cardiac muscle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract. Single channel and [3H]ryanodine binding measurements were performed to test for a direct functional interaction between 2,3-butanedione 2-monoxime (BDM) and the skeletal and cardiac muscle sarcoplasmic reticulum Ca2+ release channels (ryanodine receptors). Single channel measurements were carried out in symmetric 0.25 m KCl media using the planar lipid bilayer method. BDM (1–10 mm) activated suboptimally Ca2+-activated (0.5–1 μm free Ca2+) single, purified and native cardiac and skeletal release channels in a concentration-dependent manner by increasing the number of channel events without a change of single channel conductances. BDM activated the two channel isoforms when added to either side of the bilayer. At a maximally activating cytosolic Ca2+ concentration of 20 μm, BDM was without effect on the cardiac channel, whereas it inhibited skeletal channel activities with IC50≈ 2.5 mm. In agreement with single channel measurements, high-affinity [3H]ryanodine binding to the two channel isoforms was increased in a concentration-dependent manner at ≤1 μm Ca2+. BDM was without a noticeable effect at low (≤0.01 μm) Ca2+ concentrations. At 20 μm Ca2+, BDM inhibited the skeletal but not cardiac channel. These results suggest that BDM regulates the Ca2+ release channels from the sarcoplasmic reticulum of skeletal and cardiac muscle in a concentration, Ca2+ and tissue-dependent manner.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 57 (1986), S. 1851-1855 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A CAMAC-based LSI microcomputer coupled to a VAX minicomputer with a high (200 kbyte/s) transfer rate network make possible real-time data processing and control of a data-intensive plasma physics experiment. The system is constructed out of reliable, commercially available components. Most of the network software is written in fortran and is easy to maintain and modify. A description of its four software layers and illustrations of the type of experiments it has been used on are presented.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science, Ltd
    International journal of cosmetic science 26 (2004), S. 0 
    ISSN: 1468-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Telomeres protect the ends of chromosomes, which contain the DNA that comprises the genetic information. Without telomeres and their special way of replicating, chromosome ends dwindle away and also are easily damaged. Loss of telomere function promotes cancer and may occur in human aging. Most enzymes – the catalysts that carry out life's chemical reactions – are made of protein. In contrast, the enzyme telomerase, which replenishes the DNA at telomeres and protects them, is a ribonucleoprotein complex consisting of core components – a protein reverse transcriptase and the telomerase RNA moiety – as well as additional protein factors that regulate the action of telomerase on telomeres.A major known function of telomerase is to elongate telomeric DNA. This function is achieved by the enzyme copying a short template sequence within the inbuilt telomerase RNA, into telomeric DNA repeat sequences. The mechanism of telomerase has been analyzed and telomerase has been shown to be a dimeric enzyme. Functional dimerization of human telomerase requires a novel RNA–RNA interaction between two telomerase RNA molecules in the same enzyme complex. Telomeric repeats are added to the end of the chromosomal DNA by telomerase, elongating the chromosome and thus compensating for losses of terminal DNA that occur upon nuclease action and incomplete DNA replication of the ends of the chromosomal DNA.However, telomerase is largely repressed in proliferating cultured human fibroblasts or after a few passages of culturing of primary human keratinocytes. The normal senescence of such fibroblasts and other human cell types in culture can be overcome by forced expression of telomerase in these cells. The lifespan of the cells is extended and they grow healthily, generally without evidence of impairment to DNA checkpoint pathways.We analyzed the effects of forced expression of telomerase on the growth characteristics and sensitivity to ultraviolet (UV) irradiation of primary human cells in culture. Normal primary human foreskin epithelial keratinocytes and fibroblasts were stably infected with retroviral vector expressing various versions of hTERT (the reverse transcriptase protein component of telomerase), or the control empty retroviral vector pBABEpuro. Cells selected for the puromycin drug resistance marker were continuously passaged in puromycin-containing media, and their telomeres, cell growth and cell viability analyzed. The responses of such cells expressing telomerase to different challenges, including UV exposure were analyzed and found to differ from those of control cells.
    Type of Medium: Electronic Resource
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