Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Alterations of local cerebral blood flow, phorbol 12,13-dibutyrate binding activity, and histological damage during acute focal ischaemia in rat brain (1996)
    Springer
    Acta neurochirurgica 138 (1996), S. 1118-1125 
    Details
    ISSN: 0942-0940
    Keywords: Cerebral ischaemia ; local cerebral blood flow ; ischaemic damage ; PDBu binding activity ; duration of middle cerebral artery occlusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The alterations of the local cerebral blood flow (LCBF),3 H-phorbol 12,13-dibutyrate (PDBu) binding activity were measured, and histological findings were also examined during the closed time course (0, 1, 3, 5, 7 hour) after middle cerebral artery occlusion (MCAO) in rat brain to assess the complex pathophysiology of acute focal ischaemia. From 1 to 3 hours after the start of MCAO, significant (p 〈 0.01) hyperreactivity of the second messenger system involving PDBu binding may be present, despite low perfusion of LCBF, and severe damage in the striatum whereas sparing almost completely the cortex on histological examination. At 5 hours, the PDBu binding activity increased slightly but not significantly but is reduced markedly at 7 hours after MCAO compared with the control group. The measurement of PDBu binding activity, additionally to measuring the LCBF and observation of the histological change might be a useful indicator in determining the threshold and duration of ischaemia which cause functionally irreversible cell damage in the brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01412317
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Serotonin Synthesis Rate Measured in Living Dog Brain by Positron Emission Tomography (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 56 (1991), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: In vivo measurements by positron emission tomography of the brain serotonin synthesis rates in the normal dog, in the dog with increased plasma tryptophan concentration, and in the dog under different arterial oxygen tensions are described. The method described here permits repeated measurements in the same brain for the first time. An increase in the plasma tryptophan concentration from 16.6 to 191.5 and then to 381 μM resulted in close to a linear increase in the brain serotonin synthesis rate. When PaO2 was raised from 76 ± 2 to 106 ± 1 mm Hg, the rate of serotonin synthesis in the dog brain increased from 39 ± 8 to 54 ± 10 pmol g−1 min−1. The estimates of the Michaelis-Menten constants, Kappm and Vmax for the transport of tryptophan through the blood-brain barrier are 303 ± 54 μM and 63 ± 10 nmol g−1, min−1, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1991.tb02575.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Regional differences in local cerebral blood flow (LCBF) and glucose utilization (LCGU) in the basal ganglia after occlusion of the middle cerebral artery in rats (1987)
    Springer
    Journal of neural transmission 68 (1987), S. 271-287 
    Details
    ISSN: 1435-1463
    Keywords: Cerebral ischemia ; cerebral blood flow ; cerebral glucose utilization ; basal ganglia ; dopamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Acute effects of occlusion of the middle cerebral artery on local cerebral blood flow (LCBF) and local cerebral glucose utilization (LCGU) were investigated quantitatively in separate groups of rats using (14C) iodoantipyrine (14C-IAP) or (14C) 2-deoxyglucose (14C-DG) respectively. LCBF was significantly decreased in the ipsilateral cerebral cortices (to less than 45 ml/100 g/min or 30% of the control side) and the lateral part of the striatum (to 22 ml/100 g/min or 10% of the control side) which were supplied by the middle cerebral artery. No significant changes in LCBF were found in any other of the subcortical regions. In contrast to the unanimous decrease of LCBF in the ipsilateral cortices and the lateral striatum, complexed changes in LCGU were found in not only the cortex and striatum but also in many other subcortical regions which were closely related to the distribution of the mesencephalic dopamine neurons, such as globus pallidus, substantia nigra, subthalamic nucleus, nucleus accumbens, olfactory tubercle and lateral habenular nucleus. Relevance of this putative neurotransmitter and GABA on the glucose metabolism in ischemic brain is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02098503
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of 11C-labelled BCNU and SarCNU in gliomas studied by PET (1991)
    Springer
    Journal of neuro-oncology 10 (1991), S. 47-55 
    Details
    ISSN: 1573-7373
    Keywords: nitrosoureas ; glioma ; BCNU ; SarCNU ; PET ; chemotherapy ; brain tumor ; BBB
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This paper describes the study of the pharmacodynamics of two 11C-labelled nitrosoureas, 1,3-bis-(2-chloroethyl) nitrosourea (BNCU) and sarcosinamide chloroethylnitrosourea (SarCNU), both labelled in the carbonyl position. Distribution of the radioactivity as measured by positron emission tomography was compared to the distribution of radioactivity observed after injection of 68Ga-EDTA, this being used as an indicator of the blood-brain barrier integrity around the brain tumor. Data suggest that the new nitrosourea, SarCNU, most likely enters brain tissue by different mechanism(s) than BCNU, which enters by diffusion. Data also indicate that use of SarCNU may result in a better tumor to brain ratio than BCNU.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00151246
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Synthesis of “no-carrier-added”11C-labelled nitrosoureas (1985)
    Springer
    Journal of radioanalytical and nuclear chemistry 89 (1985), S. 45-54 
    Details
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract This paper decribes syntheses for the11C-labelled chemotherapeutic drug, CCNU,11C-labelled BFNU and CFNU (analogs of BCNU) as well as an improved synthesis for11C-BCNU. Also discussed are procedures for the separation of dual isomers in the case of11C-labelled CCNU and CFNU. The specific activity of these “no-carrier-added” radiopharmaceuticals was approximately 104 lower than expected for a carrier-free product. The syntheses were normally finished 20–25 min after the end of the collection of11C-COCl2. Chemical and radiochemical purity of the final product, as determined by HPLC and TLRC respectively, was at least 98%. The syntheses yielded 10–25 mCi of nitrosourea ready for use in PET studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02070202
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...