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  • 1
    Electronic Resource
    Electronic Resource
    Comparison of the antitussive effects of codeine phosphate 20 mg, dextromethorphan 30 mg and noscapine 30 mg using citric acid-induced cough in normal subjects (1979)
    Springer
    European journal of clinical pharmacology 16 (1979), S. 393-397 
    Details
    ISSN: 1432-1041
    Keywords: codeine ; dextromethorphan ; noscapine ; cough ; citric acid ; normal subjects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary 1. Protection by codeine 20 mg, dextromethorphan 30 mg, noscapine 30 mg, and placebo against citric acid-induced cough was determined in eighteen healthy subjects. 2. Drug differences occurred at 2 1/2 h following ingestion of the drugs but not at 1 1/4 h. 3. Only codeine 20 mg had a greater antitussive action than placebo, but dextromethorphan 30 mg also did not differ from codeine 20 mg. 4. This technique may offer a useful screening test for the activity of new potential antitussive compounds in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00568199
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  • 2
    Electronic Resource
    Electronic Resource
    Titrimetric analysis of carboxylic acid-anhydride mixtures with tetrabutylammonium hydroxide (1974)
    s.l. : American Chemical Society
    Analytical chemistry 46 (1974), S. 1331-1334 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60345a021
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  • 3
    Electronic Resource
    Electronic Resource
    Viral Infections of Domestic Animals (1964)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Microbiology 18 (1964), S. 269-300 
    Details
    ISSN: 0066-4227
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.mi.18.100164.001413
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  • 4
    Electronic Resource
    Electronic Resource
    GOSSES BLUFF AIRBORNE MAGNETIC SURVEY (1972)
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical prospecting 20 (1972), S. 0 
    Details
    ISSN: 1365-2478
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Physics
    Notes: An airborne magnetic survey of an area of 580 km2 centred on Gosses Bluff was flown in 1968. This survey formed part of a joint project by the Australian Bureau of Mineral Resources and the United States Geological Survey to evaluate the hypothesis that Gosses Bluff is of impact origin.Analyses of the magnetic data show that shallow sources of magnetic disturbance flank the Bluff on its southern side. Interpretation of the magnetic anomalies indicates their source to be shock-melted breccias of possible Jurassic age.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2478.1972.tb00621.x
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  • 5
    Electronic Resource
    Electronic Resource
    D-Amino acids in chronic renal failure and the effects of dialysis and urinary losses (1994)
    Springer
    Amino acids 6 (1994), S. 283-293 
    Details
    ISSN: 1438-2199
    Keywords: Amino acids ; Chronic renal failure ; Plasma ; Urine ; D-amino acids ; CAPD ; D-Tyrosine ; D-Phenylalanine ; Haemodialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Total D-amino acids were measured in plasma for 20 non-dialysed patients (creatinine clearance 〈 12 ml/minute), 20 on CAPD, 20 on haemodialysis and 20 normals. Plasma D-tyrosine and D-phenylalanine were measured in 8 of each group by HPLC. Total D-amino acids, D-tyrosine and D-phenylalanine were significantly greater for patients than normals. D-amino acids and D-tyrosine correlated with creatinine and were decreased during HD. During dialysis, the mean losses for D-tyrosine and D-phenylalanine were similar, about 0.2 mg/CAPD exchange and 3 mg/4 hour haemodialysis (i.e. 2% of the total amino acid, as in plasma). Clearance was unaffected by stereochemical configuration. Urinary losses/24 hour in the non-dialysed patients were 0.35 mg D-tyrosine and 0.25 mg D-phenylalanine. Clearance for D-phenylalanine was greater than for the L-enantiomer. Increases in D-amino acids in renal failure are probably due to depletion of D-amino acid oxidase, but may be enhanced by a D-amino acid rich diet, peptide antibiotics and D-amino acid oxidase inhibiting drugs and metabolites. Possible toxic effects need further investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00813748
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  • 6
    Electronic Resource
    Electronic Resource
    Amino acids and the kidney (1991)
    Springer
    Amino acids 1 (1991), S. 183-192 
    Details
    ISSN: 1438-2199
    Keywords: Amino acids ; Kidney ; Nutrition ; Phenylalanine ; Tyrosine ; Uraemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The kidney has an important role in the metabolism of amino acids and control of plasma concentrations. Reabsorption by the tubules recovers about 70g/day of amino acids, derived from both the diet and metabolism in other tissues. Amino acids regulate haemodynamics and proteolysis and maintain integrity of the kidney. Abnormal plasma and muscle amino acid profiles in chronic renal failure (i.e. low essentials and tyrosine with high nonessentials) first indicated malnutrition, which can be partially corrected by supplementation. The loss of effective kidney tissue and uraemia, in addition to nutrition, have been considered in studies of phenylalanine hydroxylation used to investigate low tyrosine. Investigations in normal kidney have shown that glutamine uptake maintains acid-base homeostasis, glycine and citrulline are removed, and serine and arginine are released into the circulation. These metabolic processes are impaired in chronic renal failure. Uraemia affects most tissues and causes malnutrition, whilst acidosis activates catabolism of amino acids and proteins in muscle. Hyperinsulinaemia probably depresses plasma branchedchain amino acids and particularly valine. These abnormalities are less likely to respond to dietary supplementation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00806915
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  • 7
    Electronic Resource
    Electronic Resource
    Steroid responsive cyclical neutropenia (1984)
    Springer
    Annals of hematology 48 (1984), S. 153-159 
    Details
    ISSN: 1432-0584
    Keywords: Cyclical neutropenia ; Prednisolone ; Remission ; Bone marrow culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 19-year old girl with severe cyclical neutropenia associated with life-threatening infection and who responded dramatically to the administration of oral prednisolone is described. During reduction and eventual cessation of steroid therapy normal or near normal neutrophil counts have been maintained, and there has been parallel improvement in clinical well-being. Prior to therapy and at a time of peak blood neutrophil count low numbers of granulocyte-macrophage progenitor cells (CFU-C) were found in the patient's bone marrow, and her lymphocytes co-cultured with normal marrow failed to show the inhibitory effect normally seen with normal lymphocytes. The findings in this patient are compared with those in the two other cases where cyclical neutropenia has been shown to respond to steroids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320338
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  • 8
    Electronic Resource
    Electronic Resource
    Head-Shake distributions during self-maintained dependence on morphine, methadone, and l-alpha-acetylmethadol (LAAM) in the rat (1977)
    Springer
    Psychopharmacology 54 (1977), S. 105-107 
    Details
    ISSN: 1432-2072
    Keywords: Morphine ; Methadone ; LAAM dependence ; Self-administration ; Head shakes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Adult female Sprague-Dawley rats were prepared with chronic cortical and muscle electrodes and i.v. cannulas, made tolerant to and physically dependent on morphine, and trained to lever press for i.v. morphine self-injections to maintain dependence. Methadone or l-alpha-acetylmethadol (LAAM) was then substituted for morphine in some of these rats. During self-maintained dependence on either morphine or methadone, head shakes appeared and increased in frequency before lever pressing for selfinjections. In contrast, there were fewer head shakes during LAAM dependence, which were evenly distributed over the entire duration of the interinjection interval. These findings suggest a relationship between head-shake distributions, drug-seeking behavior, and the pharmacodynamics of these three narcotics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426549
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  • 9
    Electronic Resource
    Electronic Resource
    CFU-C inhibitors in aplastic anaemia (1984)
    Springer
    Annals of hematology 48 (1984), S. 61-74 
    Details
    ISSN: 1432-0584
    Keywords: Aplastic anaemia ; CFU-C ; Lymphocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Peripheral blood lymphocytes from 15 patients with marrow aplasia were tested for their ability to inhibit the proliferation of normal granulopoietic precursor cells (CFU-C) in agar culture, relative to the inhibitory effect of normal lymphocytes studied in parallel. Eight of the 15 patients with marrow aplasia had lymphocytes which were significantly less inhibitory to normal CFU-C than controls whereas 3 patients had lymphocytes which were significantly more inhibitory. Two further patients who had recovered from marrow aplasia were also studied. The effect of patient's plasma and normal plasma on normal CFU-C proliferation was also studied and in 1 case a potent inhibitor of granulopoiesis was demonstrated. In 9 cases CFU-C could be cultured from patient's marrow, and parallel studies examining the effects of lymphocytes or plasma on patient's CFU-C. In none of the 9 marrow samples tested was inhibition by patient lymphocytes significantly greater than normal controls. The results highlight the heterogeneity inherent in the study of aplastic states and serve to underline the importance of controls. In only a minority of cases (20%) was lymphocyte suppression of normal granulopoiesis by lymphocytes from patients with aplastic anaemia significantly greater than normal lymphocyte suppression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320032
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  • 10
    Electronic Resource
    Electronic Resource
    Case Report: Myelofibrosis Presenting as Splenic Tumor (1999)
    Springer
    Digestive diseases and sciences 44 (1999), S. 1817-1822 
    Details
    ISSN: 1573-2568
    Keywords: MYELOFIBROSIS ; SPLENIC TUMOR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018838505479
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