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  • 1
    Electronic Resource
    Electronic Resource
    Determination of plasma serotonin by high-performance liquid chromatography with pre-column sample enrichment and fluorimetric detection
    Amsterdam : Elsevier
    Journal of Chromatography B: Biomedical Sciences and Applications 417 (1987), S. 378-384 
    Details
    ISSN: 0378-4347
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0378-4347(87)80132-9
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  • 2
    Electronic Resource
    Electronic Resource
    Solidification of an aqueous salt solution in the presence of thermosolutal convection (1993)
    Springer
    Heat and mass transfer 28 (1993), S. 205-216 
    Details
    ISSN: 1432-1181
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Description / Table of Contents: Zusammenfassung Es wurde der Gefriervorgang einer Wasser-Salzlösung (H2O-NaCl) an der senkrechten Wand einer rechtekigen Kammer experimentell untersucht, und zwar unter dem Einfluß der durch Temperatur- und Konzentrationsunterschiede ausgelösten Freikonvektion. Die mitgeteilten Ergebnisse betreffen die räumlichen und zeitlichen Temperaturänderungen im Fest-, Misch- und Flüssigkeitsgebiet. Die Konzentrationsänderungen wurden durch selektive Entnahme von Flüssigkeitsproben in Verbindung mit refraktometrischen Messungen ermittelt. Das Gefriergeschehen hängt wesentlich von der durch Temperatur- und Konzentrationsunterschiede gesteuerten Konvektionsströmung ab. Infolge ständiger Anreicherung der Flüssigkeit mit Salz entwickelte sich eine konzentrationsstabilisierte Schicht am Boden der Versuchskammer, die mit zunehmender Eisbildung anwuchs und vom konvektiv beeinflußten Flüssigkeitsgebiet durch eine dünne Grenzschicht getrennt blieb.
    Notes: Abstract The freezing of water-salt (sodium chloride) solution on a vertical wall of a rectangular cavity has been studied experimentally. The influence of thermally and solutally driven natural convection on the freezing process has been examined. The spatial and temporal variations of the temperature in the solid, mush and liquid regions have been recorded. By selectively withdrawing liquid samples and in conjunction with a refractometer, the concentration variation has been studied. The thermosolutal convective flow strongly influenced the rate of freezing. Due to the continuous rejection of salt, a solutally stratified stable region developed at the bottom of the test cell. The thickness of this region increased with the progress of freezing and it was separated from the remaining bulk liquid, where convective flow was present, by a thin interface.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01541191
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  • 3
    Electronic Resource
    Electronic Resource
    Phase I–II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: A regimen with a low subjective toxic burden (1997)
    Springer
    Annals of oncology 8 (1997), S. 865-870 
    Details
    ISSN: 1569-8041
    Keywords: breast cancer ; chemotherapy ; fluorouracil ; folates ; vinorelbine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Vinorelbine, is an active drug in the treatment of metastatic breast cancer and has a favorable toxicity profile. Its combination with other effective and well-tolerated cytotoxics may thus be beneficial. We investigated the therapeutic effect of a combination of vinorelbine plus 5-fluorouracil and folinic acid as first-line treatment in patients with metastatic breast cancer. Patients and methods: Forty-five patients with advanced or metastatic breast cancer were enrolled in this phase I–II study and treated with 5-fluorouracil (350 mg/m2 i.v. on day 1 to 3), folinic acid (100 mg/m2 i.v. on day 1 to 3) and vinorelbine given on days 1 and 3 at the dose of 25 mg/m2 (dose level 1), or 30 mg/m2 (dose level 2). Therapy was given on an outpatient basis every three weeks. Results: Phase I: Dose limiting toxicity (DLT) occurred at the second dose level of vinorelbine (30 mg/m2), with two out of three patients developing severe constipation (‘ileus-like syndrome’ grade 4), and fever (grade 2). Consequently, the dose evaluated in the phase II study was 25 mg/m2. Phase II: Objective responses were observed in 24 of 39 evaluable patients (95% confidence interval (95% CI), 47% to 77%). There were seven complete responses (18%), 17 partial responses (44%), and for nine patients (23%) disease was stable. Only six patients (15%) experienced disease progression. The median response duration was 10 months (range 6 to 24+) and the median time to progression was eight months (range 2 to 24+). Granulocytopenia was the most frequently observed side effect, with a grade 4 nadir being observed in 30 patients (77%), with four hospital admissions due to febrile neutropenia. Nausea, vomiting, and anorexia were mild to moderate and reported by less than half of the patients. Alopecia was moderate and occurred in about one-third of the patients. The other side effects were mild and easily manageable. Conclusions: This effective combination chemotherapy of vinorelbine, 5-fluorouracil and folinic acid is comparable to other first-line regimens in terms of efficacy, and is subjectively well tolerated, thus deserving a test in randomized trials in the advanced and adjuvant settings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008209429204
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  • 4
    Electronic Resource
    Electronic Resource
    High-dose ifosfamide plus adriamycin in the treatment of adult advanced soft tissue sarcomas: Is it feasible? (1998)
    Springer
    Annals of oncology 9 (1998), S. 917-919 
    Details
    ISSN: 1569-8041
    Keywords: doxorubicin ; high-dose ifosfamide ; soft tissue sarcomas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Adriamycin (ADM) and ifosfamide (IFO) are the two most active agents in the treatment of soft tissue sarcomas (STS) with a clear dose-response relationship. We evaluated the feasibility and toxicity of a high-dose IFO-plus-ADM combination. Patients and methods: Fourteen patients with advanced disease and nine patients in adjuvant setting received IFO 12.5 g/m2 in 120-hour continuous infusion with Mesna uroprotection and ADM 20 mg/m2 on days 1–3 and G-CSF every three weeks. Results: Twenty-three patients received 89 chemotherapy cycles (70 cycles at full dose). Seventeen patients received the planned treatment, and nine patients required dose reductions. We observed grade 3–4 neutropenia in 52 cycles (59%)/20 patients; grade 3–4 thrombocytopenia in 16 cycles (18%)/nine patients; grade 3–4 anaemia in 24 cycles (27%)/11 patients. Eight patients experienced febrile neutropenia and six patients required blood transfusions. Conclusions: While feasible, this regimen showed heavy toxicity. Nevertheless, 74% of the patients were able to complete the planned treatment. Adjustment of the schedule of IFO continuous infusion to improve this combination is currently under investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008311901856
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  • 5
    Electronic Resource
    Electronic Resource
    Primary chemotherapy in operable breast cancer with favorable prognostic factors: A pilot study evaluating the efficacy of a regimen with a low subjective toxic burden containing vinorelbine, 5-fluorouracil and folinic acid (FLN) (1999)
    Springer
    Annals of oncology 10 (1999), S. 993-996 
    Details
    ISSN: 1569-8041
    Keywords: 5-fluorouracil ; breast cancer ; neoadjuvant ; primary chemotherapy ; vinorelbine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Biological considerations support the use of primary chemotherapy in operable breast cancer; and despite wide variations of used regimens, clinical studies consistently show a significant tumor response allowing breast conservation in many patients otherwise canditates for mastectomy. We investigated the efficacy and the acceptance of a combination chemotherapy with vinorelbine, 5-fluorouracil and high-dose folinic acid in operable breast cancer with favorable prognostic factors and tested the relationship of hormone receptor status, Ki67, p53, c-erbB2 and bcl-2 with treatment response. Patients and methods: Thirty-nine patients (median age 51 years, range 36–71 years), eight with T1, twenty-eight with T2 and two with T3 lesions, were treated with 5-fluorouracil (350 mg/m2, i.v. on day 1 to 3) preceded by folinic acid (100 mg/m2 i.v. on day 1 to 3) and vinorelbine, given on days 1 and 3 at the dose of 20 mg/m2 (FLN regimen). Therapy was administered on an outpatient basis every three weeks. Non responders had surgery after three courses, while complete or partial responders underwent surgery after six courses. All but one were evaluable for response and toxicity. Results: Objective responses were observed in 23 of the 38 evaluable patients (61%; 95% CI: 46%–76%): three complete responses (8%) and 20 partial responses (53%). Fifteen patients (39%) had stable disease, of whom nine (23%) had minor response. None of the patients had disease progression during treatment. Objective responses were significantly associated with no expression of estrogen and/or progesteron receptors and 〉50% decrease in Ki67 after induction chemotherapy. Tolerance was excellent and none of the patients experienced grade 2 alopecia. Conclusions: The ‘moderate’ efficacy of this regimen might be partially due to the selection of patients with high expression of steroid hormone receptors and low proliferation rate, which have an unfavorable impact on response to this chemotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008389106575
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