ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
In this paper, the adsorption of human serum albumin (HSA), human serum fibrinogen (HFG)and human serum immune globulin (IG) on surfaces of diamond like carbon film (DLC), diamond film(DF) and graphite has been studied. The adsorption isotherms of single component protein solution andthe competitive adsorption of binary system have been investigated by radioisotope 125 I labeling method.Results showed that (1) the adsorptive amounts of HSA on DLC is more than that of HFG, but the adsorptiveamounts of HFG on DF and graphite are apparently more than those HSA; (2) the relative competitiveadsorption ability of three proteins on DF and graphite surfaces is HFG 〉 IG 〉 HSA, but that on DLC isHFG ≈ HAS 〉 IG, comparison with HSA, there is no apparent competitive adsorption superiority on DLCfor HFG. These results indicated that there is no apparent distinction for the adsorption of three humanserum proteins on DLC, but the adsorption of HFG on DF and graphite takes precedence in varyingdegrees. It probably makes rational explanation for the result of blood-compatibility tests in vitro thatDLC is good, but DF and graphite are worse
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.336-338.1814.pdf
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