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  • 1
    Electronic Resource
    Electronic Resource
    Recruiters & Academia (2005)
    [s.l.] : Nature Publishing Group
    Nature 433 (2005), S. 442-442 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Top 10 tips for success in graduate school Ensure that the choices you make enhance both your work and your career prospects. 10 Starting out Don't take classes as an undergraduate that you will take as a postgrad. Go to college to get a broad education — go to ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nj7024-442b
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Myosin phosphorylation, agonist concentration and contraction of tracheal smooth muscle (1982)
    [s.l.] : Nature Publishing Group
    Nature 298 (1982), S. 871-872 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Canine tracheal smooth muscles were obtained and treated as previously described8 except that: (1) muscles were maintained in the muscle baths as flat sheets in order to minimize non-uniform rates of agonist diffusion to receptor sites; (2) individual smooth muscle strips were maintained at a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/298871a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Actin and myosin I in the nucleus: what next? (2005)
    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 12 (2005), S. 742-746 
    Details
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Several recent publications have demonstrated the importance of nuclear actin and nuclear myosin I in transcription. Here we review these publications and their implications. In addition, we discuss some important issues that should be addressed to gain a more comprehensive understanding of how ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nsmb983
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Morphologic characterization of cultured smooth muscle cells isolated from the tracheas of adult dogs (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 218 (1987), S. 313-328 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The goals of our study were to isolate smooth muscle cells from the trachealis muscle of adult dogs and to characterize the cells morphologically when they were maintained in primary culture. Enzymatic digestion of the muscle yielded 4.8 ± 1.8 × 106 viable smooth muscle cells per gram of tissue. When placed in culture, these cells rapidly proliferated until confluence was reached. The proliferating cells in culture differed from the cells in the intact tissue in that they stained less intensely for smooth muscle myosin, developed immunoflurescent staining for the intermediate filament protein vimentin, and lost many of the ultrastructural properties of the intact muscle. Only within nodules of cells in the confluent cultures were these ultrastructural properties preserved. Cultures of canine tracheal fibroblasts differed from these smooth muscle cell culturs in that the fibroblasts did not stain for smooth muscle myosin and did not form nodules at confluence. We concluded that adult canine airway smooth muscle cells may be maintained in primary culture, that the confluent cultures contain nodules of cells with many morphologic characteristics of the intact muscle, and that these preparations may be distinguished from cultured canine tracheal fibroblasts on specific morphologic grounds.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092180313
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    Paper (German National Licenses)
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  • 5
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    The Impact of Membrane Protein Diffusion on GPCR Signaling (2022)
    Details
    Publication Date: 2023-01-06
    Description: Spatiotemporal signal shaping in G protein-coupled receptor (GPCR) signaling is now a well-established and accepted notion to explain how signaling specificity can be achieved by a superfamily sharing only a handful of downstream second messengers. Dozens of Gs-coupled GPCR signals ultimately converge on the production of cAMP, a ubiquitous second messenger. This idea is almost always framed in terms of local concentrations, the differences in which are maintained by means of spatial separation. However, given the dynamic nature of the reaction-diffusion processes at hand, the dynamics, in particular the local diffusional properties of the receptors and their cognate G proteins, are also important. By combining some first principle considerations, simulated data, and experimental data of the receptors diffusing on the membranes of living cells, we offer a short perspective on the modulatory role of local membrane diffusion in regulating GPCR-mediated cell signaling. Our analysis points to a diffusion-limited regime where the effective production rate of activated G protein scales linearly with the receptor–G protein complex’s relative diffusion rate and to an interesting role played by the membrane geometry in modulating the efficiency of coupling
    Language: English
    Type: article , doc-type:article
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