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Digitale Medien

Three different classes of oral antidiabetic drugs do not increase insulin binding and insulin-inducedRNA synthesis in human fibroblast cultures (1985)

Frorath, B. ; Dreyer, M. ; Rüdiger, H. W.

Springer

Research in experimental medicine 185 (1985), S. 45-49

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Details

ISSN: 1433-8580

Schlagwort(e): Oral antidiabetic drugs ; Extrapancreatic action ; Cultured fibroblasts ; Insulin receptor ; RNA synthesis

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary We describe insulin binding and insulin-mediated RNA synthesis on seven human fibroblasts strains in culture initiated from skin biopsies in the presence of three oral antidiabetic agents, Metformin, Gliquidone, and a non-sulfonylurea antidiabetic drug (B × DF 591 ZW), which belong to different chemical classes. At least at a nontoxic pharmacologic concentration of 1 µg/ml these drugs did not influence the number and affinity of insulin receptors, nor did they increase the insulin-mediated RNA synthesis. We conclude that cultured fibroblasts do not represent the proper target for an evaluation of an extrapancreatic action of oral antidiabetic drugs.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01851526

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