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Digitale Medien

Ethanol and tetrahydroisoquinoline alkaloids do not produce narcotic discriminative stimulus effects (1983)

Shearman, Gary T. ; Herz, Albert

Springer

Psychopharmacology 81 (1983), S. 224-227

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Details

ISSN: 1432-2072

Schlagwort(e): Discriminative stimulus ; Fentanyl ; Morphine ; Ethanol ; Tetrahydropapaveroline ; Salsolinol ; 3-Carboxysalsolinol ; Rat

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Male Sprague-Dawley rats were trained in a two lever food-reinforced procedure to discriminate between the effects of saline and the synthetic narcotic analgestic fentanyl (0.04 mg/kg). After acquisition of this discrimination, generalization tests with morphine, ethanol and some tetrahydroisoquinoline alkaloids were conducted. The rats dose-dependently generalized the effect of morphine but did not generalize the effects of either ethanol, tetrahydropapaveroline, salsolinol or 3-carboxysalsolinol to the fentanyl discriminative stimulus. Thus, these data do not support a biochemical link between ethanol and opiates.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00427266

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