ISSN:
1432-0428
Schlagwort(e):
Fructose-rich diet
;
aldose reductase inhibitor
;
ONO-2235
;
diabetic neuropathy
;
polyol pathway
;
sorbitol
;
sciatic nerve
;
retina
;
erythrocyte
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary Streptozotocin-diabetic rats were maintained on a 72% fructose diet for 4 weeks and some were treated with an aldose reductase inhibitor (either alrestatin: 0.9 g · kg−1 · day−1 or ONO-2235: 50 mg · kg−1 · day−1). Fructose feeding significantly influenced the development of impaired motor nerve conduction velocity in the diabetic rats and this effect was positively correlated with sorbitol accumulation in the sciatic nerve of diabetic rats maintained on a fructose-rich diet. Treatment with ONO-2235, a new aldose reductase inhibitor, prevented both slowing of motor nerve conduction velocity and elevation of nerve sorbitol concentration. On the other hand, erythrocyte sorbitol levels were significantly correlated to those of the sciatic nerve (r=0.86, p〈0.001) and the retina (r=0.91, p〈0.001) in these animals. Thus, our findings suggest that increased polyol pathway activity may be related to the pathogenesis of diabetic neuropathy and erythrocyte sorbitol concentrations may prove a useful indicator for the presence of diabetic complications.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00273868
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