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Digitale Medien

Copper metabolism in the LEC rat: Involvement of induction of metallothionein and disposition of zinc and iron (1991)

Sugawara, N. ; Sugawara, C. ; Katakura, M. ; [weitere]

Springer

Cellular and molecular life sciences 47 (1991), S. 1060-1063

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Details

ISSN: 1420-9071

Schlagwort(e): LEC rat ; copper ; metallothionein ; ceruloplasmin ; zinc ; iron

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Abstract The Cu concentration was about 40 times higher in the liver of LEC (Long-Evans with a cinnamon-like coat color) rats aged 77 days (227.5±21.6 μg/g liver) than in Fischer rats (5.2±0.1 μg/g liver). However, in the kidney and brain of the LEC rats, Cu concentrations were lower than in these organs of the Fischer rats. Cu concentration in the hepatic metallothionein fraction was about 130 times higher in the LEC rats than in the Fischer rats. The LEC rats showed markedly low concentrations of Cu in the serum and bile. It seems likely that excretion of Cu from the liver into the bile and blood (as ceruloplasmin) is inherently lacking in the LEC rat.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01923342

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