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  • Artikel: DFG Deutsche Nationallizenzen  (3)
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  • Artikel: DFG Deutsche Nationallizenzen  (3)
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  • 1
    Digitale Medien
    Digitale Medien
    Role of prostaglandin endoperoxide PGG 2 in inflammatory processes (1977)
    [s.l.] : Nature Publishing Group
    Nature 265 (1977), S. 170-173 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] During a search for potential non-steroidal anti-inflammatory drugs, one was found to possess a high degree of biological activity, yet it was inactive asan inhibitor in the routine PG synthetase assay4. In rat foot oedema, this compound, 2-aminomethyl-4-t-butyl-6-iodophenol (MK-447), exhibited ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/265170a0
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  • 2
    Digitale Medien
    Digitale Medien
    The regulatory role of steroid hormones on the PGF/PGE ratio in target tissues (1976)
    Springer
    Inflammation research 6 (1976), S. 165-170 
    Details
    ISSN: 1420-908X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Estrogen has been found to regulate cyclic nucleotide and prostaglandin levels in the rat uterus. This action of estrogen is associated with a simultaneous rise in cyclic GMP and PGF levels. Alterations in PG levels are either independent of or secondary to the formation of cyclic GMP. The mechanism by which estrogen induces the rise in uterine PGFs, although not precisely defined, is associated with alterations of the enzymes rather than of the substrates involved with prostaglandin synthesis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01972202
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  • 3
    Digitale Medien
    Digitale Medien
    Biologically active derivatives of fatty acids (1977)
    Springer
    Inflammation 2 (1977), S. 285-294 
    Details
    ISSN: 1573-2576
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The causal role assigned to the E and F prostaglandins in inflammatory processes, implied by the antiinflammatory action of prostaglandin synthetase inhibitors, is not consistent with the findings reported here that a compound (MK-447) capable of increasing levels of these prostaglandins is antiinflammatory in classical animal models of acute inflammation. That both MK-447 and prostaglandin synthetase inhibitors depress the enzymatic formation of PGG2 from arachidonic acid suggests that this endoperoxide plays a pivotal role in acute inflammation. However, in view of the intermediate nature of PGG2, it seems likely that such a pivotal role for this substance is a function of its ability to be converted to other inflammatory mediators. Possible candidates for a causal role are thromboxane A2 (TXA2) prostacyclin (PGI2), both of which derive from PGG2. However, direct evidence is presented to show that an oxygen equivalent released in the enzymatic conversion of PGG2 to PGH2 is a prime factor in inflammation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00921008
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