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  • Articles: DFG German National Licenses  (3)
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  • Articles: DFG German National Licenses  (3)
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  • 1
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background A recent report provided evidence that a disintegrin and metalloprotease domain 33 (ADAM33), a member of the ADAM family, is a novel susceptibility gene in asthma linked to bronchial hyper-responsiveness. However, there has been no investigation of the genetic role of ADAM33 variants in nasal allergy.Objective The purpose of this study was to test the association between ADAM33 polymorphisms and Japanese cedar pollinosis (JCPsis), a most common seasonal allergic rhinitis in Japan.Methods We conducted a case–control association study among a Japanese population, involving 95 adult individuals with JCPsis and 95 normal healthy controls. A total of 22 single-nucleotide polymorphisms (SNPs) in ADAM33 were genotyped using PCR-based molecular methods.Results Six SNPs of ADAM33 gene, three in introns (7575G/A, 9073G/A and 12540C/T) and three in the coding region (10918G/C, 12433T/C and 12462C/T), were strongly associated with JCPsis (P=0.0002−0.022 for absolute allele frequencies) and most of the SNPs were in linkage disequilibrium with each other. A higher frequency of the common alleles of these SNPs was noted for the subjects with JCPsis in comparison with healthy controls. We also identified a haplotype associated with the disease susceptibility. In addition, associations were found between ADAM33 polymorphisms and various cedar pollinosis phenotypes including clinical severity, eosinophil counts in nasal secretion and allergen-specific IgE levels in sera, but not total serum IgE levels.Conclusion These results indicate that polymorphisms in the ADAM33 gene are associated with susceptibility to allergic rhinitis due to Japanese cedar pollen, but the functional relationship still needs clarification.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 36 (1981), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have deqeloped a para-carotid approach for internal jugular cannulation which utlizes only the carotid artery as a landmark. This technique allows us to locatedhe puncture site regardless of an individual patient's physical, skeletal or postural variations. This study was undertaken in the period from January 1979 to June 1980 on 456 consecutive patients in a wide range of age groups and various clinical conditions. The overall success rate was 96.1%. The only complications encountered during our study were Five carotid artery punctures with formation of two haematomas.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Fatigue & fracture of engineering materials & structures 20 (1997), S. 0 
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract— Low cycle fatigue tests under axial, torsional and combined axial-torsional loading were conducted using thin-wall tubular specimens of Ti-6A1–4V titanium alloys. Two kinds of alloys with different microstructures, the (α+β) and β alloys, were investigated in fatigue tests at room temperature. When the failure life was correlated with the equivalent plastic strain, the life in axial loading shifted toward the lower life region compared with those in other loading modes in both alloys. Dominant surface cracks propagated in mode I under axial and combined loading in the two alloys. Although growth by the mode II type was predominant under torsional loading, the growth direction of the main crack coincided with the specimen axis in the (α+β) alloy, but the circumferential direction in the β alloy. The cracking morphology depended on the microstructure, especially under the torsional mode of loading, and was simulated successfully by using the proposed model for crack initiation.
    Type of Medium: Electronic Resource
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