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  • 1
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 6 (1873), S. 345-352 
    ISSN: 0365-9496
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 77 (1955), S. 820-821 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 88 (1966), S. 1251-1256 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 43 (1994), S. 79-81 
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1420-9071
    Keywords: CQP 201-403 ; 8α-amino-ergolines ; ergot pharmacology ; D-2 agonist ; endocrine ; CNS ; cardiovascular actions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The profile of action in animals of CQP 201-403, a novel 8α-amino-ergoline, is in most aspects that of a very potent dopaminomimetic, both as a prolactin secretion inhibitor, and at the levels of the CNS and the cardiovascular system. Qualitatively CQP 201-403 differs slightly from bromocriptine and apomorphine in its effects on the CNS (no influence on serotonin metabolism in the rat cortex; induction of masculine mounting behavior in rats) and the cardiovascular system of the dog (reflex tachycardia in response to a blood-pressure fall). In man the new compound proved to be highly active in lowering prolactin serum levels and to be more potent than bromocriptine (Parlodel®).
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1440
    Keywords: Herbizide ; Paraquat ; Vergiftung ; Hämoperfusion ; Herbicides ; Paraquat ; Intoxication ; Hemoperfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary “Continuous hemoperfusion” (8 h/day for 2–3 weeks) was performed in two patients suffering from severe paraquat intoxication. On account of paraquat plasma concentrations a fatal outcome due to pulmonary fibrosis would have been expected in both cases. However, both patients survived following “continuous hemoperfusion” therapy. Coated activated charcoal seems to have a higher affinity for paraquat than lung tissue.
    Notes: Zusammenfassung „Kontinuierliche Hämoperfusion“ (ca. 8 h täglich während 2–3 Wochen) wurde wegen Paraquatvergiftung an zwei Patienten durchgeführt, bei denen aufgrund der Höhe der Paraquat-Plasma-Spiegel mit der Entwicklung einer letalen Lungenfibrose gerechnet werden mußte. Beide Patienten konnten durch diese Maßnahme der „Kontinuierlichen Hämoperfusion“ gerettet werden. Beschichtete Aktivkohle scheint eine größere Affinität für Paraquat zu haben als die Lungen.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 14 (1935), S. 1582-1584 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 71 (1993), S. 423-434 
    ISSN: 1432-1440
    Keywords: Cholecystolithiasis ; Supersaturation ; Gallstones ; Cholesterol ; Cholecystitis ; Occlusion of the cystic duct
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The development and growth pattern of solitary and multiple cholesterol gallbladder stones was defined using cholecystography in a prospective study of 48 patients whose initial cholecystograms indicated a stone-free gallbladder and who developed gallstones within the subsequent 5 years. Radiological observations performed over 365 patient-years were complemented by macroscopic examination, radiograms, scanning electron microscopy, and chemical analysis of gallstones from these and other patients obtained at cholecystectomy. Solitary gallstones were found to develop after a precursor phase of over 2 years during which free-floating crystal laminae of cholesterol formed. These laminae subsequently aggregated loosely and underwent external compaction and internal remodeling by movement of cholesterol molecules to form compact spheroids. A single lamina was observed to function as a nucleus for the development of a solitary stone shaped as an ellipsoid. About 10% of solitary stones were found to have a solitary pigment stone in their center. In contrast, multiple cholesterol gallstones formed without a precursor phase. Innumerable, very thin cholesterol crystals appeared which very abruptly aggregated to form spheres of up to 1 mm in diameter. Within 3 months a second aggregation took place in which these spheres coalesced to form mulberry stones. Mulberry stones in turn were transformed either to faceted stones (if many were present in the gallbladder) or to barrel stones (if few were present) over a period of 3 years. It is proposed that temporary occlusion of the cystic duct leads to supersaturation of bile with calcium bilirubinate and/or calcium carbonate which in turn promotes deposition of either or both of these calcium salts on the surface of single or multiple gallstones. For multiple gallstones, this process or the deposition of additional cholesterol crystals seals the gallstone surface and is followed by metamorphosis of the stone center.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 71 (1993), S. 208-213 
    ISSN: 1432-1440
    Keywords: Allergy ; Whooping cough ; Pertussis toxin ; IgE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To evaluate whether pertussis induces the development of allergy, a prospective study was performed in 25 children aged 0.8–12.2 years. The patients underwent allergy diagnostics during pertussis infection and at a follow-up visit 8–14 months later. Diagnostic criteria included the medical history of the patients and their families, a modified skin prick test, measurement of serum IgE and radio-allergosorbent test screening for specific sensitizations. At the time of pertussis, serum IgE concentration in the study group was 62+ 30 kU/ml. At the follow-up visit, there was a significant increase in serum IgE to 137 ± 51 kU/ml, which was also significantly higher than IgE in an age-matched control group. Children at a significantly higher risk for developing IgE increase or new allergic sensitizations were those with a family history of allergy or potentially allergic disease in their personal history. Our results indicate that pertussis may induce IgE production in affected children.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Lung 142 (1970), S. 7-19 
    ISSN: 1432-1750
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über Erfahrungen in Prophylaxe und Behandlung schwerer postoperativer Nachblutungen in der Thoraxchirurgie berichtet. Ist es zu einer größeren Nachblutung gekommen, so beseitigt die möglichst frühzeitige Rethorakotomie mit der Ausräumung der Coagel die Einflußstauung und den Blutungsschock und bringt optimale funktionelle Ergebnisse. Darstellung anhand der Operationsstatistik von ca. 1967 Fällen in 6 Jahren (1963/1968). Durch eine postoperative Blutungsprophylaxe mit Trasylol® und Trans-AMCHA konnte die Zahl der schweren Nachblutungen bei Eingriffen der Thoraxchirurgie gegenüber Trasylol® und ACS von 2,3% auf unter 1% gesenkt werden. Der Beginn der Thrombo-Embolieprophylaxe wurde dabei auf den Operationstag oder 1. postoperativen Tag vorverlegt. Dosierung und Nebenwirkungen sowie die theoretischen Grundlagen werden besprochen. In letzter Zeit haben Bloedner, Wachsmuth und Viereck und auch Wolfart u. Mitarb. über postoperative Blutungen in der Thoraxchirurgie, ihre Prophylaxe und Behandlung berichtet. Dabei erscheinen uns folgende Punkte wichtig: 1. Die postoperative Blutung ist unter den Gegebenheiten des Thorax immer ein ernstes Problem. 2. Als Blutungsmechanismus ist Hyperfibrinolyse häufig und anscheinend zunehmend anzunehmen. 3. Zur Behandlung ist baldigste Rethorakotomie mit Ausräumung der Coagel die beste Methode. 4. Blutungsprophylaxe kann die funktionellen Ergebnisse verbessern und die Thromboserate sowie die Hepatitisrate herabsetzen. Im eigenen Krankengut haben wir in der Zeit von 1963–1968, also in 6 Jahren, unter 1967 Thorakotomien in 32 Fällen wegen einer Blutung eine Rethorakotomie mit akuter Indikation 6–36 Std nach dem ersten Eingriff durchgeführt. Über das Krankengut und die Eingriffe orientieren die Tabellen 1 und 2. Dabei wurde die Indikation zur Rethorakotomie immer dann gestellt, wenn a) größere Blutmengen (mehr als 1000 ml) in wenigen Stunden in der Saugdrainage abliefen, b) die Röntgenkontrolle ein zunehmendes Hämatom zeigte und größere Coagelmassen im Thorax anzunehmen waren. Bei 32 Rethorakotomien fanden wir dabei nur 6mal (= 19%) eine Gefäßblutung, die versorgt werden konnte. (In 3 Fällen lagen arterielle Blutungen aus Brustwandgefäßen vor, 2 Fälle hatten eine Blutung aus einer kleinen Zwerchfellarterie in den Bauchraum und Thorax und 1mal lag eine Lungenvenenblutung vor.) In allen übrigen 26 Fällen (= 81%) handelte es sich um diffuse Sickerblutungen. Die Komplikation war allein durch Ausräumen der Blutcoagel und durch Auffüllen des Kreislaufes zu beherrschen. Nur selten kam es nach der Hämatomausräumung nochmals zu einer nennenswerten Blutung.
    Notes: Abstract This paper reports experiences with prophylaxis and treatment of postoperative hemorrhage in thoracic surgery. In a series of 1967 thoracotomies performed for a variety of reasons between the years 1963 and 1968, 32 urgent secondary interventions were necessary 6 to 32 hours postoperatively. In only 6 patients were these interventions thought to be due to localized bleeding. In 26 cases (81%) hemorrhage and shock were cured by removal of blood clots only. In case of hemorrhage complications, it seems, that a secondary thoracotomy, performed soon after, is the best treatment to bring about early recovery and best functional results. If it is supposed that 80% of these hemorrhages have a causal connection with fibrinolysis a postoperative prophylaxis with antifibrinolytic agents should be useful. We observed less bleeding complications, when Trasylol® and 1-aminocapromic acid were used; an even greater diminution was noted (from 2.3% to less than 1%), when Trasylol® and aminomethylcyclohexane acid were given from 24 to 48 hours (or longer) postoperatively. There was a remarkable diminution of fluids discharged into suction containers, less conserved blood was needed, and postoperative hepatic and thrombo-embolic complications decreased (Hepatitis 1%, Embolism 0,3%). In 500 cases during the years 1968 and 1969 we encountered only two incidents of hemorrhage. Most of the operations during the last two years (including lobectomies for tuberculosis) were performed without conserved blood. Embolism and hepatitis were also absent. The prophylaxis for embolism was usually started 24 hours postoperatively (in selected cases somewhat earlier). Heparine and Dicumarol were used in the follow-up treatment.
    Type of Medium: Electronic Resource
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