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Digitale Medien

Human immune response to allergens of house dust mite, Dermatophagoides pteronyssinius (1988)

Saint-Remy, J. M. R. ; Lebrun, P. M. ; Lebecque, S. J. ; [weitere]

Oxford, UK : Blackwell Publishing Ltd

Allergy 43 (1988), S. 0

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ISSN: 1398-9995

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: Specific antibodies isolated by immunoabsorption on four main insolubilized allergens from Dermatophagoides pteronyssinus (DPT) had the following isotypic distribution: in 16 atopic patients, 52% IgG, 40% IgM, 8% IgA, 0.1% IgE and, in 12 non-atopic individuals, 48% IgG, 46% IgM, 6% IgA, 0.03% IgE. The ratios between geometric means of antibody values in each class (atopic vs non-atopies) were 2.4 for IgG, 2.0 for IgM, 2.8 for IgA and 66.7 for IgE. The amount of anti-DPT antibodies in IgG subclasses (did not follow the usual distribution of total IgG subclasses, i.e., IgG1 〉 lgG2 〉 IgG3 〉 IgG4. In atopies the order was IgG2 〉 IgG1 〉 IgG4 〉 lgG3 and in non-atopies, IgG4 〉 IgGl - IgG2 〉 IgG3 although 6/12 of the latter had no detectable (〈 0.5 μg/ml plasma) IgG4.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1398-9995.1988.tb00427.x

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