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  • 1
    ISSN: 1432-0428
    Keywords: Obese-hyperglycaemic mice ; isolated pancreatic islets ; islet transplantation ; serum glucose ; islet volume ; autoradiography ; islet cell replication ; immunocytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Implantation of allogeneic pancreatic islets encapsulated in Millipore diffusion chambers has been reported to normalize the obese-hyperglycaemic syndrome in mice. In the present study, both young and adult ob/ob mice remained hyperglycaemic and gained weight after intrasplenic implantation of 500 isogeneic islets isolated from lean mice. Such islets normalized the elevated blood-glucose of alloxan-diabetic lean mice. Morphometric analysis of the intrasplenically implanted islets showed that the mean islet volume in the ob/ob mice was five times larger than that of the lean, non-diabetic mice. Immunocytochemical staining of the spleens showed an increased proportion of B-cells in the enlarged, intrasplenic islets in the ob/ob mice. Moreover, autoradiographical examination of these islets demonstrated the presence of several labelled cells. These results suggest that the growth of the implanted “lean” islets is due to extrapancreatic factors which stimulate islet cell replication in the obese-hyperglycaemic mouse.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0428
    Keywords: Somatostatin ; diabetic Chinese hamsters ; islet cells ; A1-cells ; glucagon ; insulin ; hypothalamus ; stomach
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The inhibitory effects of somatostatin on the release of insulin and glucagon, as well as its localization to the A1-cells (D-cells) of the pancreatic islets, suggest a role of this peptide in carbohydrate metabolism. In the present study we have measured the percentage islet volume, the total weight of the A1-cells and the somatostatin concentration in the pancreas of normal and spontaneously diabetic Chinese hamsters. In addition, the concentration of somatostatin in the stomach and hypothalamus as well as the insulin and glucagon content of the pancreas were evaluated. The percentage islet volume in the normal hamsters was 0.66±0.12, which was in marked excess of that in the diabetic group, 0.38±0.04. Similarly, the total weight of the A1-cells in the controls, 0.17±0.02 mg, was significantly larger than that in the diabetic animals, 0.12±0.02 mg. In agreement with these findings there was also a decreased pancreatic concentration of insulin and somatostatin, whereas the glucagon concentration was in the normal range. Also the stomach of the diabetic hamsters showed a decreased concentration of somatostatin. In the hypothalamus the total content of somatostatin appeared similar in the two groups of animals, but when expressed per mg wet weight this value was also decreased in the diabetic hamsters. These observations strongly suggest that, in the diabetic Chinese hamster, apart from the well-known B-cell deficiency there exists also a decreased functional activity of the somatostatin-producing cells.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0428
    Keywords: Spontaneous diabetes ; mutation ob ; obesehyperglycemic mice ; growth hormone ; sulfate uptake of costal cartilage ; epiphyseal width ; insulin resistance ; pituitary morphology ; liver hexokinase ; liver glucokinase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé La cause de la résistance prononcée à l'insuline caractérisant le syndrome obèse-hyperglycémique de la sourisobob n'est pas encore connue. Cette étude a été entreprise dans le but d'évaluer le rôle pathogénique éventuel de l'hormone de croissance (GH), mesurantin vivo le taux d'incorporation de sulfate dans le cartilage costal chez les souris normales et obèse hyperglycémiques de même nichées et à des âges différents. Les résultats suivants ont été obtenus: a) L'administration de GH augmente l'incorporation de sulfate dans le cartilage costal des deux types de souris, b) La présence de GH augmente la résistance à l'insuline des animaux obèses-hyperglycémiques. c) L'incorporation de sulfate est considérablement augmentée chez la souris obèse âgée de plus d'un mois et reste élevée jusqu'à environ 10 mois. Chez des animaux de 17 mois, elle est ramené à un taux semblable à celui des souris normales d'une même nichée. En plus, l'épiphyse du tibia était plus large chez la souris obèse. Une étude morphologique de l'hypophyse a été faite ensuite puisqu'il n'était pas établi que les taux élevés d'incorporation de sulfate soient dûs à une activité endogène accrue de la GH et/ou à l'insulinémie élevée observée chez la souris obèse en cette période de la vie. L'absence de différences structurelles ou quantitatives entre les cellules α hypophysaires des souris normales et obèses n'exclut pas l'éventualité que l'activité de sulfation accrue soit due à l'insulinémie élevée plutôt qu'à une augmentation de l'activité de l'hormone de croissance. Une activité de la glycokinase caractérisée par unK m élevé a été trouvée dans le foie des souris normales et obèses. Chez la souris obèse, une élévation significative de cette activité enzymatique, — valors que l'activité de l'hexokinase n'est pas augmentée-suggère que les cellules hépatiques ne sont pas impliquées par la résistance à l'insuline décrite dans le syndrome obèse — hyperglycémique.
    Abstract: Zusammenfassung Die Ursache der Insulinresistenz derobob Maus ist noch immer unbekannt. Um festzustellen, ob dem Wachstumshormon eventuell pathogenetische Bedeutung zukomme, wurde die Inkorporation von Sulfat in den Rippenknorpel vonobob Mäusen und normalgewichtigen Kontrolltieren verschiedener Altersklassen gemessen. Die Injektion von Wachstumshormon erhöht die Inkorporation von Sulfat bei allen Tieren. Bei den fettsüchtigen nahm nach der Injektion außerhalb die Insulinresistenz zu. Die spontane Inkorporation von Sulfat in die Rippenknorpel war bei denobob Tieren nach dem ersten und ungefähr bis zum zehnten Lebensmonat signifikant erhöht. Bei 17 Monate alten Tieren wurden den bei Normaltieren gemessenen entsprechende Werte gefunden. Weiterhin war die Breite der Tibia-Epiphyse der obesen Maus größer. Da es auf Grund dieser Resultate nicht möglich war, zu unterscheiden, ob die erhöhte Inkorporation tatsächlich auf erhöhte Konzentrationen endogenen Wachstumshormons und/oder auf die gleichzeitig bestehende Hyperinsulinämie zurückzuführen sei, wurden die Hypophysen der Tiere histologisch untersucht. Dabei konnten zwischen den obes-hyperglykämischen und den normalen Tieren weder strukturelle Unterschiede noch solche in der Zahl der A-Zellen festgestellt werden. Es ist deshalb vorderhand unmöglich, die Hyperinsulinämie als Ursache der bei denobob Mäusen festgestellten Erhöhung der Sulfatinkorporation auszuschließen. Bei Kontrollundobob-Mäusen war die Glucokinaseaktivität, nicht aber diejenige der Hexokinase erhöht. Die Aktivitätssteigerung der Glucokinase war bei denobob Mäusen deutlich ausgeprägter und es wird deshalb angenommen, daß die Leberzellen derobob Tiere nicht insulinresistent sind.
    Notes: Summary The cause of the pronounced insulin resistance of the hereditary obese-hyperglycemic syndrome in mice (obob) is so far unknown. To evaluate whether growth hormone (GH) is of pathogenetic significance in this context thein vivo incorporation of sulfate into costal cartilage was measured in obese-hyperglycemic mice and their lean littermates at various ages. It was found that a) GH administration raised the sulfation activity of the costal cartilage in both types of mice; b) the hormone further increased the insulin resistance of the obesehyperglycemic animals; c) the sulfate incorporation of the obese mice was considerably elevated after 1 month of age and remained high until the age of about 10 months. In 17 months old animals it had returned to a level similar to that of the lean littermates. In addition, the epiphyseal width of the tibia was increased in the obese mice. Since it was not clear whether the increased rate of sulfate in corporation was due to an elevated endogenous GH activity and/or the high serum insulin levels prevailing in the obese mice at this period of life a study of the pituitary morphology was carried out. The lack of obvious structural or quantitative differences between the pituitary alpha cells of the lean and obese mice did not exclude the possibility that the elevated sulfation activity was caused by the high serum insulin levels rather than an increased circulating GH activity. — Glucokinase activity, characterized by a highK m value, was found in the livers of both lean and obese mice. A significant elevation of this enzyme activity, but not of the hexokinase activity, in the obese mice strongly suggests that the insulin resistance does not extend to the liver cells in the obese-hyperglycemic syndrome.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0428
    Keywords: Isolated islets of Langerhans ; A2-cells ; B-cells ; glucose oxidation ; fatty acid oxidation ; glucagon.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'oxydation du glucose et des acides gras a été mesurée dans les îlots normaux de Langerhans chez le cobaye, ainsi que dans les îlots riches en cellules A2 du cobaye traité à la streptozotocine. Le taux d'oxydation de ces composés dans les cellules A2 et les cellules B du cobaye a été estimé. Dans les cellules B, l'oxydation du glucose et de l'acide octanoique a fortement répondu à des changements dans les taux extra-cellulaires de ces substrats. L'acide palmitique ne semble pas avoir été oxydé par les cellules B. Au contraire, l'oxydation de l'acide octanoique et de l'acide palmitique dans les cellules A2 était très sensible aux changements dans la concentration des acides gras extra-cellulaires. La sensibilité de l'oxydation du glucose envers les changements dans la concentration du glucose était comparativement faible. Le taux élevé de l'oxydation des acides gras dans les cellules A2 corrobore l'hypothèse que le degré du métabolisme des acides gras dans ces cellules joue un rôle important dans la régulation de la sécrétion du glucagon.
    Abstract: Zusammenfassung An normalen Langerhansschen Inseln vom Meerschweinchen und an mit A2-Zellen angereicherten Inseln von streptozotozin-behandelten Meerschweinchen wurde die Oxidation von Glucose und Fettsäuren gemessen und die Oxidationsrate in A2-Zellen und B-Zellen des Meerschweinchens bestimmt. In den B-Zellen hing die Oxidation von Glucose und Octansäure stark von den Änderungen der extracellulären Konzentrationen dieser Substanzen ab. Palmitinsäure schien in den B-Zellen nicht oxidiert zu werden. Dagegen war die Oxidation von Oktansäure und Palmitinsäure in den A2-Zellen sehr von den Schwankungen der extracellulären Fettsäurekonzentration abhängig. Die Änderung der Glucoseoxidation bei Schwankungen der Glucosekonzentration war im Verhältnis dazu gering. Die hohe Oxidationsrate der Fettsäuren in den A2-Zellen unterstützt die Theorie, daß der Fettsäuremetabolismus dieser Zellen eine wesentliche Rolle in der Regulierung der Glucose-sekretion spielt.
    Notes: Summary Glucose and fatty acid oxidation has been measured in normal guinea-pig islets of Langerhans, and in A2-cell rich islets from streptozotocin-treated guinea-pigs. The rate of oxidation of these compounds in guinea-pig A2-cells and B-cells has been estimated. In the B-cells, the oxidation of glucose and octanoic acid responded markedly to changes in the extracellular levels of these substrates. Palmitic acid did not appear to be oxidized by the B-cells. In contrast, the oxidation of octanoic acid and palmitic acid in the A2-cells was very sensitive to changes in the extracellular fatty acid concentration. The sensitivity of glucose oxidation to changes in the glucose concentration was small by comparison. The high rate of oxidation of fatty acids in the A2-cells supports the view that the rate of fatty acid metabolism in these cells plays an important role in the regulation of glucagon release.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Acta mechanica solida Sinica 7 (1994), S. 172-178 
    ISSN: 0894-9166
    Keywords: structure-borne emission ; moment actuator ; free angular velocity ; moment mobility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract In this paper, the measuring methods of the rotational components, i. e. the free angular velocity and the moment mobility are presented. The performance of a moment actuator composed of two magnetostrictive rods (Tb0.3 Dy0.7 Fe1.95) is discussed. Both theory and experiment show that the performance of the moment actuator does not influence the measurement results of the moment mobilities basically but affects the efficiency for exciting rotation. The efficiency for exciting rotation has also been calculated.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    International journal of social welfare 7 (1998), S. 0 
    ISSN: 1468-2397
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology
    Notes: In Denmark the life expectancy of women has been declining since 1980, and is now the lowest of all OECD countries. Based upon analyses of the different trends in mortality of 35–64-year-old women in Denmark compared to women in Norway and Sweden, national differentials in external determinants of morbidity and premature mortality are described. The excess mortality of women in Denmark is linked to lifestyle factors: tobacco smoking, alcohol and drug consumption. We discuss the possible impact of other external factors: full-time employment, work load, job insecurity, unemployment, single motherhood, and social isolation. The main hypothesis is that the daily life of women in Denmark has deteriorated over the years, and that changes in lifestyle and behaviour in part can be explained by evolved strategies in order to cope with anxiety and strain. Contrary to conditions in Sweden, the welfare system in Denmark has not facilitated the combination of child-bearing and paid work. The analysis points to the importance of including data of external stressors in discussions of national variances in lifestyle factors linked to premature mortality.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0011-2240
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Nuclear Physics, Section B 3 (1967), S. 234-240 
    ISSN: 0550-3213
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Nuclear Physics, Section B 215 (1983), S. 527-554 
    ISSN: 0550-3213
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Nuclear Physics, Section B 190 (1981), S. 504-518 
    ISSN: 0550-3213
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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