Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 45 (1996), S. 62-67 
    ISSN: 1420-908X
    Keywords: Neutrophil ; Defensin ; Phagocytosis ; Adhesion molecule ; Superoxide anion generation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Defensins are known to be the microbicidal components of neutrophil granules, which contribute to oxygen-independent antimicrobial mechanisms. In this study, we have examined the effect of defensins on neutrophil functions, such as adhesion, superoxide anion generation, phagocytosis and chemotaxis. Guinea-pig defensins increased the expression of CD11b, CD11c and CD54 (intercellular adhesion molecule ICAM-1) on human neutrophils, and induced adhesion of guinea-pig and human neutrophils. When the effect of guinea-pig defensins on superoxide anion generation was examined, defensins inhibited superoxide anion generation during phagocytosis of complement-opsonized particles. Furthermore, defensins inhibited complement-dependent phagocytosis. However, they did not inhibit the binding of complement-opsonized particles to neutrophils, suggesting that defensins possibly inhibit complement-dependent phagocytosis by affecting the ingestion step but not the binding step. Defensins exhibited neither chemotactic nor chemokine activity. Interestingly, 10–20% of total defensins were released extracellularly from phagocytosing neutrophils. Together these observations indicate that, in addition to their antimicrobial activity, defensins may have the ability to modulate the functions of neutrophils at sites of infection or inflammation.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Pure and applied geophysics 155 (1999), S. 625-647 
    ISSN: 1420-9136
    Keywords: Key words: Faulting, fractures, earthquake swarm, permeability, porosity, seismicity.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract —Spatio-temporal variation of rupture activity is modeled assuming fluid migration in a narrow porous fault zone formed along a vertical strike-slip fault in a semi-infinite elastic medium. Pores are assumed to be created in the fault zone by fault slip. The effective stress principle coupled to the Coulomb failure criterion introduces mechanical coupling between fault slip and pore fluid. The fluid is assumed to flow out of a localized high-pressure fluid compartment in the fault with the onset of earthquake rupture. The duration of the earthquake sequence is assumed to be considerably shorter than the recurrence period of characteristic events on the fault. The rupture process is shown to be significantly dependent on the rate of pore creation. If the rate is large enough, a foreshock–mainshock sequence is never observed. When an inhomogeneity is introduced in the spatial distribution of permeability, high complexity is observed in the spatio-temporal variation of rupture activity. For example, frequency-magnitude statistics of intermediate-size events are shown to obey the Gutenberg–Richter relation. Rupture sequences with features of earthquake swarms can be simulated when the rate of pore creation is relatively large. Such sequences generally start and end gradually with no single event dominating in the sequence. In addition, the b values are shown to be unusually large. These are consistent with seismological observations on earthquake swarms.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1432-0428
    Keywords: Keywords Gestational diabetes, pregnancy, stature, obesity, risk factors, undernourishment.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. To examine the association between maternal stature and gestational diabetes mellitus.¶Methods. We studied a sample of 5564 consecutive Brazilian women 20 or more years old, who were pregnant for approximately 21–28 weeks, had no history of diabetes outside pregnancy and were attending general prenatal care units in six state capitals in Brazil from 1991 to 1995. We did a 2-h, 75-g oral glucose tolerance test, defining gestational diabetes by World Health Organisation criteria.¶Results. Those in the shortest quartile of height ( ≤ 151 cm) had a 60 % increase in the odds of having gestational diabetes, independently of prenatal clinic, age, global obesity, family history of diabetes, skin colour, referral pattern, waist circumference, parity, previous gestational diabetes, education, ambient temperature and gestational age compared with the tallest quartile [odds ratio (OR) = 1.60, p = 0.005]. This association was observed for those with above median values of skinfold thickness (OR = 1.74, p = 0.006) but not for those with below median values (OR = 1.22, p = 0.51). Associations of short stature with high 2-h glycaemia ( ≥ 7.8 mmol/l) (OR = 1.61, p = 0.005) were essentially the same as those for gestational diabetes. There was, however, no association between short stature and gestational hyperglycaemia when the latter was defined exclusively by fasting values (OR = 0.97, p = 0.90).¶Conclusion/interpretation. In Brazil short stature associates with gestational diabetes, principally in women with greater fat mass. This difference in glycaemic levels is present postprandially but not in the fasting state. [Diabetologia (2000) 43: 848–851]
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 50 (1980), S. 139-142 
    ISSN: 1432-0533
    Keywords: Cerebellar neuroblastoma ; Medulloblastoma ; Synaptic vesicle ; Synapse ; Granule cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A cerebellar tumor of a 4-month-old girl was examined by light and electron microscopy. The presence of numerous synaptic vesicles in many cell processes and the occasional synaptic devices warranted the diagnosis of neuroblastoma of the cerebellum. The nature of the tumor is discussed briefly.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 62 (1984), S. 340-344 
    ISSN: 1432-0533
    Keywords: Pituitary gland ; Tumor ; Folliculo-stellate ; Cell adenoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An unusual tumor of the pituitary gland is reported. The most characteristic finding of the present tumor was the presence of numerous “colloid” and mucoid secretions. The cells were stellate in shape and there were intra- or intercellular lumina which were lined by many microvilli and occasional cilia. There were also large accumulations of 10 nm filaments in their cytoplasm. Junctional devices were well formed at the points of mutual contact of these cells. They thus correspond to fetal follicular cells of the anterior pituitary lobe. For this reason, “folliculo-stellate cell adenoma of the pituitary” would best characterize this hitherto undescribed neoplasm.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1432-0509
    Keywords: Key words: Computed tomography during arterial portography (CTAP)—Arterioportal venous shunts—Hepatocellular carcinoma—Pseudolesion—Balloon occlusion—Hepatic artery.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Computed tomography during arterial portography (CTAP) under temporary balloon occlusion of the hepatic artery (BOHA-CTAP) was introduced to evaluate pseudolesions caused by portal venous impairments such as arterioportal shunt and tumor thrombus. Methods: BOHA-CTAP was performed in seven patients with hepatocellular carcinoma and correlated with clinical outcomes. For patients with wedge-shaped defects suggestive of pseudolesions, BOHA-CTAP was obtained by a 5-F balloon occlusion catheter into the proper hepatic artery through the second 5-F introducer inserted into the common femoral artery a few centimeters below the first 5-F sheath for CTAP. Results: Eight pseudolesions were determined clinically on follow-up CT, ultrasonography, or magnetic resonance imagings. On BOHA-CTAP, five of the eight pseudolesions were eliminated, and two were diminished in comparision with conventional CTAP. One wedge-shaped defect due to tumor thrombus in the portal vein did not show any change. Conclusion: BOHA-CTAP can reduce pseudolesions caused by portal venous impairments and enable the demarcation of the true tumors. RID="" ID="" 〈E5〉Correspondence to:〈/E5〉 J. Koizumi
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 37 (1981), S. 748-750 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A new rapid method for measuring intra-cellular water content by gas chromatography and an isotopic (3H-sucrose) technique is described. Water content of circulating red cells was revealed to be 71.26±0.31%. Intra-cellular water content increased to 102.9% of its original value following addition of 3 volumes of acid-citrate-dextrose (ACD) to 20 volumes of blood.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  Polymorphism of the HLA-G gene in a Japanese population was investigated employing polymerase chain reaction (PCR)-single-strand conformation polymorphism (SSCP) analysis, PCR sequence-specific oligonucleotide (SSO) analysis, and DNA direct sequencing. Nucleotide sequence variations in exons 2, 3, and 4 of the HLA-G gene in 54 healthy Japanese individuals were examined. In addition, seven Japanese samples carrying common HLA haplotypes were analyzed. In total, nine single-base substitutions compared with the sequence of G * 01011 were identified: one in intron 1 (nucleotide position 970), one in exon 2 (the third base of codon 57: G → A), three in intron 2 (1264, 1276, and 1292), three in exon 3 (the third base of codon 93: C → T, the third base of codon 107: A → T, and the first base of codon 110: C → A), and one in intron 3 (2334). The substitution at codon 110 was non-synonymous and led to an amino acid substitution from leucine to isoleucine. The other three nucleotide substitutions in exons were synonymous. Through analysis of combinations of the exon 2, 3, and 4 nucleotide sequences we identified four alleles, which we provisionally designated GJ1, GJ2, GJ3, and GJ4. The allele frequencies were estimated to be 0.33, 0.16, 0.45, and 0.06, respectively. Nucleotide sequences of GJ1, GJ2, and GJ4 were identical to G * 01011, the clone 7.0E, and G * 01013, respectively. GJ3 was a newly observed allele and was officially designated G * 0104 by the WHO Nomenclature Committee in January 1996. Strong positive associations were observed between HLA-G alleles and HLA-A, -B, or -DRB1 alleles.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 0942-0940
    Keywords: Aneurysm ; anti-single-stranded DNA antibody ; apoptosis ; DNA fragmentation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pathological specimens were collected from 14 unruptured and 13 ruptured aneurysms at the time of clipping and studied in order to assess the underlying mechanism of rupture by investigating degeneration of the aneurysmal wall and possible involvement of apoptosis. Immunohistochemistry with anti-actin antibody showed few smooth muscle cells in the ruptured aneurysms and replacement of the muscularis layer by a fibro-hyalin tissue. However, at least one layer of smooth muscle cells was clearly observed in the unruptured aneurysms. Thus, smooth muscle cells in the wall of the ruptured aneurysms were much more degenerated than those in the wall of unruptured aneurysms. In addition, unruptured aneurysms with an angiographically smooth wall showed well-layered positive staining for anti-smooth muscle actin antibody while those with irregular shapes rarely reacted. We found, for the first time, evidence of DNA fragmentation in the aneurysmal wall. Apoptotic bodies were detected by means of a terminal transferase (TdT)-mediated dUTP biotin nick end labelling technique (TUNEL) and an anti-single-stranded DNA antibody in 54% (7/13) of the ruptured aneurysms. In contrast, apoptotic bodies were found in only 7% (1/14) of the unruptured cases. These results suggest that apoptotic cell death might be involved in the rupture of aneurysms.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 131-133 (Oct. 2007), p. 399-404 
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Notes: The effectiveness of phosphorus diffusion gettering (PDG) and related segregation coefficients for differentmetal impurities were measured applying thermal treatments in the temperature range 800-950 °C for different times.We used multi-crystalline and mono-crystalline CZ p-type wafers with different boron concentrations and differentlevels of dislocations and bulk micro-defects (BMD). In all sample types, for Cu and Ni we found complete gettering inthe temperature range investigated. In the case of Fe, the segregation coefficient increases with both increase intemperature and extension of time. The increase is qualitatively changing when going above 900 °C. At 950 °C thesegregation coefficient increases faster at shorter diffusion time but at extended diffusion time it increases slower ascompared to diffusion at 900 °C. At the same temperature and time of phosphorus diffusion the segregation coefficient isfound to be independent of the metal impurity concentration in the range of 1012-1015 cm-3 investigated. We have shownthat the presence of BMD and dislocations in bulk silicon does not impede the ability of PDG to completely remove Fe,Ni and Cu metal impurities from the bulk. Further analysis suggests that the PDG has the same gettering efficiency formono-crystalline silicon and multi-crystalline silicon. We conclude that if any bulk precipitation of Fe, Ni and Cuimpurities is present in multi-crystalline silicon it cannot seriously compete with PDG. However we found thatincreasing the boron concentration in the samples reduces the segregation coefficient of Fe, and this reduction is moresevere at lower temperatures. Finally, by applying a post anneal ramp down from 900 °C to 700 °C after phosphorusdiffusion, we found that the Fe segregation coefficient increases by a factor of 36 for lightly B doped samples, from 53 to1919, leading to a significant reduction of Fe in the bulk after 2 hours ramp down anneal
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...