ISSN:
1432-0738
Schlagwort(e):
Ah locus
;
Aryl hydrocarbon hydroxylase inducibility
;
Cytochrome P1-450
;
Benzo[a]pyrene metabolism
;
Benzo[a]pyrene mutagenesis
;
Benzo[a]pyrene recessive lethal mutations
;
β-Naphthoflavone
;
Aroclor 1254
;
Phenobarbital
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract Four strains of Drosophila melanogaster exhibit differences in aryl hydrocarbon hydroxylase (AHH) inducibility by phenobarbital or Aroclor 1254, yet do not show the typical AHH induction response when exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or benzo[a]anthracene. Adult flies were nevertheless examined for the presence of cytosolic TCDD-specific binding (Ah receptor). Berlin-K and Haag 79 exhibit AHH induction by Aroclor 1254 and possess detectable amounts of Ah receptor. Hikone-R has negligible AHH inducibility by Aroclor 1254, yet possesses measurable amounts of the receptor. Oregon-K displays AHH induction by Aroclor 1254 but has no detectable levels of the cytosolic receptor. Specific (high-affinity, low-capacity and saturable) binding of [3H-1,6]TCDD to the Ah receptor in D. melanogaster was shown to be similar to that observed in C57BL/6 mouse liver. Similar specific binding of generally labeled [3H]benzo[a]anthracene in D. melanogaster cytosol was not found. These data suggest that the presence of the Ah receptor per se, or quantity of receptor, does not guarantee AHH inducibility by TCDD or benzo[a]anthracene in adults of these four fruit fly strains.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00295157
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