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Digitale Medien

A possible role of the kidney in activating a renin preinhibitor (1975)

Baggio, B. ; Favaro, S. ; Antonello, A. ; [weitere]

Springer

Research in experimental medicine 166 (1975), S. 201-207

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Details

ISSN: 1433-8580

Schlagwort(e): Phospholipid renin preinhibitor ; Conversion to lysophospholipid renin inhibitor ; Human plasma ; Human kidney homogenate

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary In order to verify the possibility than human plasma and kidney can activate a renin preinhibitor (Phospholipid) into inhibitor (lysophospholipid), constant quantities of preinhibitor were added to plasma and kidney homogenate. Addition of preinhibitor to plasma did not modify the quantity of Angiotensin I that developed. On the other hand, addition of preinhibitor to crude kidney homogenate, followed by incubation with human angiotensinogen, caused a significant fall in the quantity of Angiotensin I generated. While plasma is deficient in the specific enzyme delegated to the transformation of preinhibitor into inhibitor, it appears that this enzyme is present in the kidney.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01852632

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