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  • Electronic Resource  (2)
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  • Electronic Resource  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Biological cybernetics 58 (1988), S. 19-33 
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract In an effort to understand the gating properties of ionic channels in biological membranes, an efficient method was developed to estimate the kinetic constants from opening-closing events of the channels. Our method is suitable to single channel patch-clamp recordings that contain several ionic channels functioning simultaneously. It is different from the maximum likelihood method previous developed by Horn and Lange, in that our method is a continuum approach and makes uses of analytic expressions of the probability density functions of the event times. Combinatorial analysis was necessary to correctly include more typical multi-channel recordings. This yields computationally quicker results than the method of Horn and Lange, which uses a discretized time series. Model-dependent portions of the code are minimal and easily modified. To illustrate the goodness of our method, we have generated the open-close processes of the patch-clamp records on a digital computer using the exponential random number generators. For multi-channel patches, we have introduced a few plausible approximations to make our algorithm more efficient. The soundness of the our approximations were tested with such measures as the fraction of the open state at time t, p open(t), and frequencies of the number of openings per run. A copy of the computer code implementing this algorithm can be obtained from the authors.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Biological cybernetics 61 (1989), S. 21-28 
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract A model of cardiac cells incorporating the membrane potential and the intracellular calcium concentration as the two dynamical variables is developed. This model is applied to simple systems of cells to investigate its behavior as a function of the model parameters. Rational entrainment is observed in systems of two coupled pacemaker cells. The propagation of the membrane potential and intracellular calcium concentration through a sheet is simulated. Behavior suggestive of circus movement tachycardias is observed.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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