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  • 1
    Digitale Medien
    Digitale Medien
    Prion Diseases and Neurodegeneration (1994)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Neuroscience 17 (1994), S. 311-339 
    Details
    ISSN: 0147-006X
    Quelle: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Thema: Biologie , Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1146/annurev.ne.17.030194.001523
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Ischemic stress induces deposition of amyloid β immunoreactivity in human brain (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 461-466 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Key words Amyloid β protein ; Ischemia ; Alzheimer's disease ; Histoblot
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The histoblot immunostaining technique for locating and characterizing amyloidogenic proteins was used to obtain information about the relationship of cerebral ischemia/hypoxia to the accumulation of amyloid β protein (Aβ). We investigated brains of 131 subjects (ages 25–94 years, mean 72 years). Three distribution patterns of Aβ immunoreactivity were identified: (1) colocalization with diffuse and neuritic plaques of Alzheimer's disease (AD) and aging; (2) diffuse punctate deposits in the cerebral cortex in association with small vessel cerebral vascular disease; and (3) cerebral cortical accumulation localized to arterial boundary zones and other regions susceptible to ischemic/hypoxic injury designated "stress-induced deposits" (SID). SID were not identified in tissue sections by immunohistochemical, Congo red or Bielschowsky silver techniques; no histological abnormalities were present in adjacent formalin-fixed tissue sections. SID occurred in subjects with histories of cerebral ischemia, and severe orthostatic hypotension. There was also an association with aging in general and with the incidence of neuritic plaques specifically. These latter findings are consistent with the hypothesis that brain ischemia/hypoxia plays a role in the pathogenesis of AD.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00294806
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Sulfated glycosaminoglycans in amyloid plaques of prion diseases (1989)
    Springer
    Acta neuropathologica 77 (1989), S. 337-342 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Amyloid ; Alzheimer's disease ; Glycosaminoglycans ; Proteoglycans ; Priom diseases
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Brain sections from cases of human Creutzfeldt-Jakob disease, Gerstmann-Sträussler syndrome, kuru, and hamster scrapie containing amyloid were examined for the presence of sulfated glycosaminoglycans (GAGs), the anionic component of proteoglycans, using the sulfated Alcian blue method and Alcian blue technique with 0.3 M and 0.7 M magnesium chloride. These studies suggest that sulfated glycosaminoglycans are part of the CNS amyloid plaques in each of the above human prion disorders as well as in experimental scrapie. All the amyloid plaques stained positively with Alcian blue at 0.3 M, and less so at 0.7 M magnesium chloride indicating the presence of sulfated GAGs. Therefore, the amyloid plaques of prion diseases possess similar histochemical features to those found in Alzheimer's disease.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00687367
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Ischemic stress induces deposition of amyloid β immunoreactivity in human brain (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 461-466 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Amyloid β protein ; Ischemia ; Alzheimer's disease ; Histoblot
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The histoblot immunostaining technique for locating and characterizing amyloidogenic proteins was used to obtain information about the relationship of cerebral ischemia/hypoxia to the accumulation of amyloid β protein (Aß). We investigated brains of 131 subjects (ages 25–94 years, mean 72 years). Three distribution patterns of Aβ immunoreactivity were identified: (1) colocalization with diffuse and neuritic plaques of Alzheimer's disease (AD) and aging; (2) diffuse punctate deposits in the cerebral cortex in association with small vessel cerebral vascular disease; and (3) cerebral cortical accumulation localized to arterial boundary zones and other regions susceptible to ischemic/hypoxic injury designated “stress-induced deposits” (SID). SID were not identified in tissue sections by immunohistochemical, Congo red or Bielschowsky silver techniques; no histological abnormalities were present in adjacent formalin-fixed tissue sections. SID occurred in subjects with histories of cerebral ischemia, and severe orthostatic hypotension. There was also an association with aging in general and with the incidence of neuritic plaques specifically. These latter findings are consistent with the hypothesis that brain ischemia/hypoxia plays a role in the pathogenesis of AD.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00294806
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
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  • 5
    Digitale Medien
    Digitale Medien
    Immunocytochemical demonstration of S-phase cells by anti-bromodeoxyuridine monoclonal antibody in human brain tumor tissues (1985)
    Springer
    Acta neuropathologica 67 (1985), S. 155-159 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Brain tumor ; Glioma ; Cell kinetics ; Bromodeoxyuridine monoclonal antibody ; Labeling index ; Immunocytochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Five patients with various brain tumors received bromodeoxyuridine (BrdU), 150–200 mg/m2 i.v.; at the time of craniotomy. Biopsied materials were fixed in 70% ethanol, sectioned, denatured with hydrochloric acid, and reacted with monoclonal antibodies against BrdU. Immunofluorescence and immunocytochemical methods were used to visualize BrdU-labeled nuclei. Our results showed that both methods demonstrated BrdU-labeled nuclei satisfactorily in tissue sections. Thus, BrdU can be used to measure the proliferative potential of human tumors in situ.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00688136
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