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  • Electronic Resource  (11)
  • 1
    Electronic Resource
    Electronic Resource
    Complete sequence of the lamprey fibrinogen .alpha. chain (1989)
    s.l. : American Chemical Society
    Biochemistry 28 (1989), S. 9801-9806 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00451a039
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  • 2
    Electronic Resource
    Electronic Resource
    Strong pyroelectric response in semiconducting Y-Ba-Cu-O and its application to uncooled infrared detection (1997)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 70 (1997), S. 3495-3497 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A pyroelectric infrared detector operating at room temperature and based on semiconducting Y-Ba-Cu-O was fabricated. The capacitor structure consisting of semiconducting Y-Ba-Cu-O layer sandwiched between two Nb electrodes was fabricated on top of a thermally isolated SiO2 bridge. The polycrystalline Y-Ba-Cu-O layer was deposited by ambient-temperature sputtering while standard Si micromachining techniques were used to etch the silicon under the oxide bridge. The pyroelectric response of the material is characterized by the temperature coefficient of polarization (p=dP/dT) which was measured to be as high as 65 nC/K cm2 without an externally applied electric field. The pyroelectric figure of merit Fd for the material was estimated to be 0.032 (cm3/J)1/2. Employing a radiometric infrared source, the room-temperature voltage responsivity RV and specific detectivity D* of the unbiased detector were measured to be over 103 V/W and 108 cm Hz1/2/W, respectively. This letter discusses the characteristics of this complementary metal-oxide semiconductor-compatible pyroelectric detector and suggests methods for the improvement for its figures of performance. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.119211
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  • 3
    Electronic Resource
    Electronic Resource
    Aryl 5-nitro-2-furyl ketone antifungal agents (1974)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 17 (1974), S. 367-369 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00249a028
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  • 4
    Electronic Resource
    Electronic Resource
    International Energy Research and Development Cooperation (1985)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Environment and Resources 10 (1985), S. 589-611 
    Details
    ISSN: 0362-1626
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.eg.10.110185.003105
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  • 5
    Electronic Resource
    Electronic Resource
    The use of transgenic and naturally occurring mutants to understand and manipulate tomato fruit ripening (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Plant, cell & environment 17 (1994), S. 0 
    Details
    ISSN: 1365-3040
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: In the years since we last reviewed the use of mutants to study tomato fruit ripening (Grierson et al. 1987), considerable information has been gained by the cloning, sequencing and identification of many mRNAs implicated in this developmental process. Genes involved in cell wall degradation, colour change and ethylene synthesis have been cloned, and antisense techniques have been developed and used to produce genetically engineered mutant fruit deficient in these aspects of ripening (see Gray et al. 1992). Recently, a previously cloned ripening gene has been used to complement a naturally occurring fruit colour mutant, yellow flesh (Fray & Grierson 1993a), and a ripening impaired mutant, ripening inhibitor, has been used to identify several new ripening-related mRNAs (Picton et al. 1993b). The chromosomal region bearing the ripening inhibitor mutation has been subjected to high-resolution mapping (Churchill, Giovannoni & Tanksley 1993) and chromosome walking experiments are in progress to identify this gene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3040.1994.tb00149.x
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  • 6
    Electronic Resource
    Electronic Resource
    Percutaneous Absorption of Clindamycin in the Pig and the Rat (1983)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 22 (1983), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Clindamycin HCI in a 3% formulation was applied twice daily to the back skin of three white (Yorkshire) and three black (Hampshire) pigs for 22 days. Partial thickness samples of skin were obtained by use of a dermatome on shaved opposite sides at 4 hours and 5 days posttreatment. More than twice the antibiotic activity (P ≤ .001) was found in thinner (254μm epidermis) samples than in thicker (1016 μm epidermis and dermis, 1 to 3) samples. A significantly higher content of antibiotic (P = 0.015) was retained in the skin of black pigs at five days posttreatment. Croups of ten Upjohn Sprague-Dawley rats were treated similarly with clindamycin phosphate in a 3 % formulation three times daily for 22 days. At termination of treatment antibiotic activity was widely distributed, whereas at five days posttreatment residual activity was confined largely to samples of treated skin. No cutaneous irritation due to treatment was observed in either study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1983.tb02147.x
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  • 7
    Electronic Resource
    Electronic Resource
    Scrotal asymmetry (1977)
    [s.l.] : Nature Publishing Group
    Nature 266 (1977), S. 282-282 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] FOR the record, I report that since reading Morgan and Corballis1 on the subject of scrotal asymmetry and Rodin's dyslexia, I have made regular observations of the asymmetry in one person who is right handed, has not got situs inversus totalis (or even partialis), has never had surgical procedures ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/266282c0
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  • 8
    Electronic Resource
    Electronic Resource
    The Huemul (1873)
    [s.l.] : Nature Publishing Group
    Nature 8 (1873), S. 263-263 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN the number of NATURE for July 24, p. 253, I see it is stated that “the Chilian Exploring Expedition has discovered a specimen of tire Huemul, an animal that has been altogether lost sight of.” The late Earl of Derby received a female specimen of this animal from Port ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/008263a0
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  • 9
    Electronic Resource
    Electronic Resource
    The Nucleolus and Trisomy (1967)
    [s.l.] : Nature Publishing Group
    Nature 215 (1967), S. 533-534 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1. Metaphase of a human lymphocyte showing a G group chromosome attached to a nucleolus. Fig. 1 is a photograph of a human lymphocyte in mitotic metaphase in which a G group chromosome is detached from the other chromosomes and related by its short arms to a persistent nucleolus. The ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/215533a0
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  • 10
    Electronic Resource
    Electronic Resource
    A phase I and pharmacologic study of DMP 840 administered by 24-hour infusion (1998)
    Springer
    Annals of oncology 9 (1998), S. 101-104 
    Details
    ISSN: 1569-8041
    Keywords: DMP 840 ; pharmacodynamics ; pharmacokinetics ; phase I
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: DMP 840, a novel bisnaphthalimide, has demonstrated promising schedule dependent anti-tumor activity in vitro and in vivo against several tumor cell lines. A phase I study was conducted to evaluate the effect of a 24-hour infusion schedule repeated every three weeks, on the therapeutic efficacy of DMP 840. Patients and methods: Fourteen patients with refractory solid tumor malignancies were treated with DMP 840 at doses of 20, 40, 50 and 60 mg/m2. Results: A combination of neutropenia, thrombocytopenia and stomatitis were dose-limiting at doses of 50 and 60 mg/m2 in both minimally- and extensively-pretreated patients. In contrast, all courses at lower dose levels were well tolerated. Pharmacokinetic analysis demonstrated that DMP 840 had a prolonged terminal half life (median 39 hours; range 25–86) and that dose-limiting events were significantly related to several indices of systemic DMP 840 exposure (P 〈 0.01, Wilcoxon Rank Sum test). Conclusion: The recommended dose of DMP 840 for further disease oriented evaluations is 40 mg/m2 administered over 24 hours every three weeks. The infusion duration evaluated in this study did not result in a substantial increase in the tolerable dose compared to shorter, less cumbersome schedules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008260515869
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