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  • 1
    Electronic Resource
    Electronic Resource
    Determination of histamine in human plasma: the European external quality control study 1988 (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 20 (1990), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: There is an increasing interest in measuring human plasma histamine levels in various clinical conditions. A variety of ‘old’ and newly developed techniques are applied to meet this demand. However, the discrepancy between reported reference values for histamine in human plasma measured using this variety of techniques, suggests the existence of a certain degree of inaccuracy and imprecision. We therefore organized an external quality control study on the reliability of current histamine determinations in European laboratories. Three lyophilized plasma quality control samples, in duplicate, covering the normal and pathological range of histamine concentrations (0–45 nmol/l), two different aqueous histamine standard samples and one solvent sample were sent to 10 laboratories for the analysis of their histamine content. The following methods were used: gas chromatography-mass spectrometry (n= 2), enzymatic single isotopic assay (n= 1), fluorometric-fluoroenzymatic assay (n= 3), radioimmunoassay (n= 3) and high performance liquid chromatography (n= 2). The study was performed and evaluated according to the approved recommendations (1983) of the International Federation of Clinical Chemistry (IFCC). The target values ±s.d. of the three plasma samples were: 39·5±4·6 nmol/1 (CV=ll·6%), 2·3 ± 2·2 nmol/1 (CV = 96%) and 8·9±1·5 nmol/1 (CV = 17%), respectively. The target values ±s.d. of the two aqueous samples were: 0·9±1·1 nmol/1 (CV = 120%; true value: 0·00 nmol/1) and 10·2 ± 0·5 nmol/1 (CV = 5·3%; true value: 10·0 nmol/1), respectively. A Youden plot of two unrelated plasma samples in the pathological range defined 7/11 results as accurate and precise. The Youden plot of the two unrelated aqueous samples only denned 6/11 results as accurate and precise. In general, estimating histamine concentrations within the normal range seemed to be the most difficult part of measuring histamine in human plasma samples. It is suggested to define reference standards, methods and laboratories for plasma histamine determinations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1990.tb02793.x
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of isoprenaline and terbutaline on urinary excretion of histamine and its two main metabolites in systemic mastocytosis (1986)
    Springer
    Inflammation research 18 (1986), S. 269-272 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Both short-term and long-term effects of the β-sympathomimetic drugs isoprenaline and terbutaline on the urinary excretion of histamine and its two main metabolites were evaluated in patients with systemic mastocytosis. In a short-term study isoprenaline and terbutaline were given intravenously during five hours to three and two patients, respectively. Compared with placebo infusion Nt-methyl-histamine excretion fell during terbutaline administration, whereas during isoprenaline no changes were observed. In a long-term study three patients received a treatment with orally administered terbutaline for 24 days. In one patient a slight reduction of the excretion of the histamine metabolites was found. In another patient the excretion of histamine and its metabolites, decreased especially during the eight days observation period after the end of the treatment. In this study we saw occasionally large and rapid changes occurring simultaneously in all three urinary parameters of histamine release. In conclusion, terbutaline can reduce histamine release in systemic mastocytosis. However, because of the small symptomatic and biochemical effects found in our patients, the clinical significance of β-sympathomimetic drug treatment in this disease has yet to be established.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01988039
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  • 3
    Electronic Resource
    Electronic Resource
    Correlation between urinary levels of histamine metabolites in 24-hour urine and morning urine samples of man: Influence of histamine-rich food (1989)
    Springer
    Inflammation research 27 (1989), S. 205-207 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In this study, we have determined and correlated the excretion of the 2 most important histamine metabolites, Nτ-methylhistamine and Nτ-methylimidazoleacetic acid, in 24-hour urine and morning urine samples of 14 normal healthy persons. We found no significant difference between morning urine and 24-hour urine samples, provided that the subjects were on a histamine-poor diet for at least 24 hours. We also studied the influence of the consumption of histamine-rich foodstuffs on the reliability of these parameters. The morning urinary Nτ-methylhistamine excretion is less affected by histamine-rich foodstuffs and therefore proposed to be the most reliable parameter for endogeneous histamine release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02222240
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  • 4
    Electronic Resource
    Electronic Resource
    Urinary excretion of histamine and some of its metabolites in man: Influence of the diet (1984)
    Springer
    Inflammation research 15 (1984), S. 189-194 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Urinary excretions of histamine,N τ-methylhistamine andN τ-methylimidazoleacetic acid have been determined in 10 normal subjects on 3 different diets, containing a very low protein, a low protein and a high protein amount. Foodstuffs which could contain histamine were excluded. The mean excretion ofN τ-methylhistamine on the second day of each diet amounted to 0.861 μmol/24 h, 1.051 μmol/24 h and 1.378 μmol/24 h, respectively. The excretions of histamine andN τ-methylimidazoleacetic acid were not affected. In 6 normal persons on a protein low diet, the excretions of histamine,N τ-methylhistamine andN τ-methylimidazoleacetic acid have been determined for 10 days. On the fifth day, to 3 persons 200 μmol of histamine was given orally, the other 3 persons received a high protein diet. The persons receiving histamine showed a strongly enhanced excretion ofN τ-methylimidazoleacetic acid, corresponding to 36.1% of the administered histamine, whereas the urinary excretions of histamine andN τ-methylhistamine were only slightly elevated. On the high protein diet, only the excretion ofN τ-methylhistamine was slightly elevated. The urinary excretions of histamine in the female subjects sometimes showed unexpectedly high values. Most probably, this phenomenon is attributable to bacterial histamine production in the urogenital tract.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972348
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  • 5
    Electronic Resource
    Electronic Resource
    Measurement ofN τ-methylhistamine concentrations in plasma and urine as a parameter for histamine release during anaphylactoid reactions (1985)
    Springer
    Inflammation research 16 (1985), S. 76-79 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract N τ-methylhistamine concentrations in plasma and urine were determined using a newly developed simultaneous determination for histamine andN τ-methylhistamine, based on isotope dilution mass fragmentography. Three groups of patients were investigated: patients receiving intravenously-administered iodamide for excretory urography, patients receiving a wasp-sting challenge, and patients treated with an intravenously-administered muscle relaxant. In all patients showing a distinct systemic anaphylactic or anaphylactoid reaction histamine andN τ-methylhistamine concentrations were found to be elevated. From the results of this study it can be concluded thatN τ-methylhistamine in plasma and urine is a good parameter for histamine release, and that the determination of this histamine metabolite are less hampered by possible artefacts (due to basophil disrupture, a very short half-life time or bacterial production) than determinations of histamine itself.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01983105
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  • 6
    Electronic Resource
    Electronic Resource
    Influence of decontamination of the digestive tract on the urinary excretion of histamine and some of its metabolites (1984)
    Springer
    Inflammation research 15 (1984), S. 238-241 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Urinary excretions of histamine, Nt-methylhistamine and Nt-methylimidazoleacetic acid have been determined for 8 healthy volunteers during 14 consecutive days. Selective decontamination of the digestive tract was performed from day 3 to day 6, followed by total decontamination from day 7 to day 10. Urinary excretions of Nt-methylhistamine and Nt-methylimidazoleacetic acid decreased to a small though significant degree (about 15–20%) after total decontamination, suggesting a histamine production by anaerobic bacteria. Cadaverine decreased for about 70% under both selective and total decontamination, suggesting that this amine in human urine mainly originates from aerobic bacteria in the intestinal tract.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972355
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  • 7
    Electronic Resource
    Electronic Resource
    Histamine in late asthmatic reactions following house-dust mite inhalation (1985)
    Springer
    Inflammation research 16 (1985), S. 252-255 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to investigate the role of histamine in the late asthmatic reaction (LAR) following house-dust mite (HDM) inhalation, we studied, with hourly intervals, urinaryN τ-methylhistamine (an important metabolite of histamine) in 14 allergic asthmatic patients before and after broncho provocation with HDM. Four patients showed an early asthmatic reaction (EAR), while 10 patients developed a LAR as well. In the hour following the EAR a significant increase in urinaryN τ-methylhistamine was observed as compared to the control day (0.01〈p〈0.05). During the LAR no increase of this metabolite was detected in the urine of the patients. Additionally, histamine was measured in broncho alveolar lavage fluid (BAF) obtained from 6 patients during the HDM-provoked LAR and compared to histamine levels in BAF from patients without a LAR, following broncho provocation. In the LAR group higher histamine levels were found than in the other patient and control groups. For the whole patient group no correlation was found between the degree of bronchial obstruction during the LAR and the BAF histamine values. No difference was found inN τ-methylhistamine in BAF between patients with LAR and controls. Thus histamine metabolite studies in the urine failed to provide evidence of involvement of histamine in the LAR, while further data are needed to interpret the results of local sampling in the lung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01983153
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  • 8
    Electronic Resource
    Electronic Resource
    Measurement of urinary Nτ-methylhistamine excretion: Correlation of a newly developed radioimmunoassay (RIA) with gas chromatography mass spectrometry (GCMS) (1991)
    Springer
    Inflammation research 33 (1991), S. 215-217 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A newly developed radioimmunoassay (RIA, Y) for the determination of urinary Nτ-methylhistamine concentrations was correlated with gas chromatography mass spectrometry (GCMS, X). In 34 urine samples, with histamine and Nτ-methylhistamine levels within our reference values, the correlation was: Y=1.47X−0.245 μmol/l (r=0.92;p-slope ≤0.0001). In 14 pathological urine samples, derived from patients with mastocytosis and having upper reference values, the correlation was: Y=1.75X−1.02 μmol/l (r=0.93;p-slope ≤0.001). In spite of the greater specificity of the monoclonal antibody for Nτ-methylhistamine compared with that of histamine, relatively high urinary histamine concentrations gave a false positive influence on the RIA results, which was 100% when the histamine/Nτ-methylhistamine ratio was about 19. Clear cases of mastocytosis can be diagnosed, using the RIA-kit, but for a more precise Nτ-methylhistamine value GCMS analyses will remain necessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01993171
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  • 9
    Electronic Resource
    Electronic Resource
    Histamine metabolism after adverse reactions due to d-tubocurarine administration (1987)
    Springer
    Inflammation research 21 (1987), S. 54-61 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated histamine release in five female patients, submitted for gynaecological surgery, after intravenous administration of the neuromuscular blocking agent d-tubocurarine. In these patients we measured the plasma levels of histamine and its metabolites, Nτ-methylhistamine and Nτ-methylimidazoleacetic acid, making use of mass fragmentographic methods. The newly developed determination of plasma Nτ-methylimidazoleacetic acid had a within-day coefficient of variation of 2.7% (n=10). Normal values of Nτ-methylimidazoleacetic acid in plasma ranged from 41.3–75.6 nmol/l (n=13). All five patients developed anaphylactoid reactions: two patients showed severe systemic reactions, one patient a minor systemic reaction and two had skin reactions only. Plasma histamine and Nτ-methylhistamine levels appeared to be the most reliable biochemical parameters for confirming both the occurrence and severity of an anaphylactoid reaction. In comparison with plasma histamine, the determination of plasma Nτ-methylhistamine is less hampered by artefacts caused by blood collection and plasma preparation. Together with the fact that the increase in plasma Nτ-methylhistamine levels after anaphylactoid reactions lasts much longer than the increase in plasma histamine levels, this leads to the conclusion that the determination of plasma Nτ-methylhistamine is a useful retrospective parameter for histamine release in this type of pathological state. The plasma Nτ-methylimidazoleacetic acid levels fluctuated considerably, showing only a significant increase after administration of d-tubocurarine in the two patients who had severe anaphylactoid reactions. This parameter is, therefore, less useful in such studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01974921
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  • 10
    Electronic Resource
    Electronic Resource
    Age dependent normal values of histamine and histamine metabolites in human urine (1988)
    Springer
    Inflammation research 23 (1988), S. 307-310 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We collected morning urine samples from normal healthy persons, who had not yet breakfasted, in the age range of 2–61 years and measured urinary excretion of histamine and its metabolites Nτ-methylhistamine and Nτ-methylimidazoleacetic acid. The values obtained (expressed in terms of urinary creatinine excretion), were age dependent up to the age of 12. Thereafter, values stabilized and were no longer are dependent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02142572
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