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  • 1
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 312-314 (July 1999), p. 275-280 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Journal of metastable and nanocrystalline materials Vol. 2-6 (July 1999), p. 275-280 
    ISSN: 1422-6375
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 235-238 (Oct. 1996), p. 355-360 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Leukotriene receptor antagonists have been demonstrated in several studies to possess bronchodilating and anti-inflammatory properties in asthma. However, there are few experimental studies performed to compare the effects of anti-leukotrienes and glucocorticoids, most used anti-inflammatory agents in asthma. In the present study, we evaluated the effects of treatment with dexamethasone or montelukast on eosinophil and mononuclear cell recruitment in an experimental model of allergen-induced chronic airway inflammation in guinea-pigs (GP).Methods GP were submitted to increasing concentrations of aerosols of ovalbumin (OVA) twice a week for 4 weeks. After 2 weeks, animals were treated daily with dexamethasone, montelukast or saline solution. After this period, GP were anaesthetized, tracheostomized, mechanically ventilated and challenged with OVA aerosol.Results Maximal changes of respiratory system resistance and elastance induced by OVA challenge were attenuated by dexamethasone (P〈0.001), but not by montelukast treatment. Neither dexamethasone nor montelukast significantly influenced bronchial oedema formation. Dexamethasone but not montelukast induced a decrease in mononuclear cells in airways (P〈0.001). Eosinophil infiltration in the bronchial wall was reduced by both dexamethasone and montelukast (P〈0.005). Only dexamethasone treatment reduced the levels of exhaled nitric oxide (P〈0.025).Conclusion Although leukotriene receptor antagonist treatment reduces eosinophil accumulation induced by multiple antigen challenges, glucocorticoid treatment attenuates both eosinophil and mononuclear cell infiltration.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of materials science 20 (1985), S. 3141-3149 
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The microstructure of melt-spun Al-17.3 at% Cu eutectic alloy ribbons with different thicknesses have been revealed by means of electron microscopy and X-ray techniques. Thick ribbons (〉20μm) consist of finely-dispersed α-Al and Al2Cu equilibrium phases showing lamellar or irregular morphology. In thin ribbons a considerable fraction of supersaturated α-Al solid solution and the metastable Al4Cu9 phase have been detected. The experimental facts on the identity of the phases, their morphology and particle size for given processing conditions are discussed within the framework of a heat flow model including the solidification process as well as post-solidification transformations. The microstructural features are considered to be determined by local and time variations of the ribbon-wheel contact.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Der Nervenarzt 67 (1996), S. 947-952 
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Hermann F. Hoffmann ; Nationalsozialismus ; Biologismus ; Psychiatriegeschichte ; Key words Hermann F. Hoffmann ; National Socialism ; Biologism ; History of psychiatry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary This study covers the life and scientific work of Hermann F. Hoffmann who was a disciple of Robert Gaup and in 1936 took over from him as head of the psychiatric clinic at the University of Tübingen. As a scientist, Hoffmann was especially involved in research into genetic problems in psychiatry. He introduced a new approach to some premises of the so-called Tübingen Psychiatric School. In 1933, he joined the NSDAP and became one of the most prominent members of the National Socialist party at the University of Tübingen. From then on, he saw himself as a prophet of a new “biological” philosophy of life. From the present point of view, Hoffmann is something of a contradiction. On the one hand, he was a good doctor and a serious scientist; on the other, he promoted biologistic ideology and a criminal regime. These biographical inconsistencies point to some inconsistencies in the history of psychiatry itself with its dialectics of philanthropy and discrimination.
    Notes: Zusammenfassung Es wird ein Überblick über das Leben und das wissenschaftliche Werk Hermann F. Hoffmanns gegeben. Hoffmann war als Schüler und Nachfolger Robert Gaupps von 1936–1944 Direktor der Tübinger Universitätsnervenklinik. Wissenschaftlich befaßte er sich besonders mit Fragen der psychiatrischen Vererbungslehre, wobei er auf eine originelle Weise Grundpositionen der sog. Tübinger Schule variierte. Nach seinem NSDAP-Beitritt 1933 gehörte Hoffmann zu den einflußreichsten Nationalsozialisten an der Universität Tübingen. Er verstand sich nunmehr als Wegbereiter einer neuen, „biologischen“ Weltanschauung. Aus heutiger Sicht erscheint die Person Hoffmanns merkwürdig gebrochen. Neben traditioneller ärztlicher Haltung und ernsthafter Wissenschaftlichkeit findet man bei ihm biologistisches Denken und Engagement für ein verbrecherisches Regime. Diese biographischen Widersprüche weisen auf Widersprüche in der Geschichte der Psychiatrie selbst hin mit ihrer Dialektik von Humanität und Ausgrenzung.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Elektrokrampfbehandlung ; Ältere Patienten ; Depression ; Nutzen ; Risiken ; Key words Electroconvulsive therapy ; Elderly patients ; Depression ; Benefits ; Risks
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Between January 1995 and June 1996, 24 inpatients at our hospital (mean age 55.6 years) were treated with electroconvulsive therapy (ECT). Clinical improvement was observed in 80% of the patients, including those without risk factors (NRG, n=16), as well as those with concomitant cardiovascular diseases (RG, n=8). During a mean period of observation of 224 days after the end of ECT 7 patients (35%) relapsed. The rate of relapse was higher in RG than in NRG patients (57.1 vs 23.1%). In all cases ECT was well tolerated; 285 applications of ECT did not result in mortality or persistent morbidity. However, RG patients may be at increased risk for the development of minor cardiovascular complications, which were noted in three RG patients (37.5%), but only in one patient (6.2%) in the NRG (Fisher’s test, P=0.09). Taken together, our results demonstrate that ECT is a safe treatment regimen for depression even in medically ill patients of old age.
    Notes: Zusammenfassung Vierundzwanzig Patienten (Altersdurchschnitt 55,6 Jahre) wurden im Zeitraum 1/95 bis 6/96 an unserer Klinik mit der Elektrokrampftherapie (EKT) behandelt. Sowohl Risikopatienten mit kardiovaskulären Begleiterkrankungen (RG, n=8) als auch Patienten mit p.d. nicht erhöhtem Risiko (NRG, n=16) zeigten in über 80% der Fälle eine klinische Besserung. Bei 7 (35%) dieser Patienten kam es während des mittleren Beobachtungszeitraumes von 224 Tagen nach Abschluß der 1. EKT-Serie zu einer erneuten Exazerbation der psychischen Störung. Dabei zeigten RG-Patienten eine höhere Rückfallquote im Vergleich zu Patienten der NRG (57,1% vs. 23,1%). In allen Fällen konnte die EKT regulär beendet werden; bei insgesamt 285 durchgeführten EKT traten keine schwerwiegenden Komplikationen auf. Allerdings hatten RG-Patienten im Vergleich zu Patienten der NRG ein höheres Risiko für das Auftreten geringfügiger kardialer Komplikationen (37,5% vs. 6,2%, Fisher’s Test p=0,09). Zusammenfassend demonstrieren unsere Ergebnisse, daß die EKT auch bei Risikopatienten eine sichere Behandlungsmethode ist.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Monatshefte für Chemie 128 (1997), S. 105-112 
    ISSN: 1434-4475
    Keywords: Absorption/fluorescence properties ; Molecular structure ; Perylene tetracarboxylic derivatives ; Vibronic structure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Theoretische Molekülgeometrien der Perylen-Derivate 3,4,9,10-Perylentetracarbonsäuredianhydrid (PTCDA), 3,4,9,10-Perylentetracarbonsäurediimid (PTCDI), N,N′-Dimethyl-3,4,9,10-Perylentetracarbonsäurediimid (MePTCDI) und 3,4,9,10-Perylentetracarbonsäuredisulfid (PTCDS) für die elektronischen ZuständeS 0 undS 1 werden vorgestellt. Auf dieser Grundlage können die elektronischen Absorptionseigenschaften interpretiert und mit experimentellen Daten verglichen werden. Die vibronische Struktur derS 0 →S 1-Absorption und derS 1 →S 2-Fluoreszenz konnte reproduziert werden. Die Analyse der aktiven Schwingungsmoden zeigen ein gegenüber Perylen vergleichbares Verhalten der Derivate.
    Notes: Summary Theoretical molecular geometries of the perylene derivatives 3,4,9,10-perylene tetracarboxylic dianhydride (PTCDA), 3,4,9,10-perylene tetracarboxylic diimide (PTCDI), N,N′-dimethyl 3,4,9,10-perylene tetracarboxylic diimide (MePTCDI), and 3,4,9,10-perylene tetracarboxylic disulfide (PTCDS) are presented for the electronic statesS 0 andS 1. On this basis, the electronic absorption properties can be interpreted and compared with experimentel data. The vibronic structure ofS 0 →S 1 absorption andS 1 →S 0 fluorescence has been reproduced. The analysis of the active vibrational modes shows a corresponding behaviour of derivatives and perylene.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nutrition 36 (1997), S. 23-27 
    ISSN: 1436-6215
    Keywords: Vitamin E ; Fleisch ; Fettgewebe ; Leber ; Eigelb ; Vitamin E ; meat ; adipose tissue ; liver ; egg yolk
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Summary The α-tocopherol content of different meat cuts was examined. Chicken thigh had the highest vitamin E content, followed by chicken breast and pork shoulder (p〈0.05). The lowest concentrations were found in longissimus dorsi muscle from pork, beef, veal and in beef shoulder. Considering the average daily lean meat consumption (105 g) in Switzerland, recommendation for daily vitamin E intake was met to 3 %. Supplementation of 200 mg α-tocopherol acetate/kg feed to pigs and laying hens significantly increased the α-tocopherol content in all examined products. The α-tocopherol accumulation differed according to the following ranking: egg yolk 〉 liver 〉 adipose tissue 〉 musculus longissimus dorsi. The α-tocopherol:energy ratios were 28.8, 7.3, 0.9 and 1.2 mg/MJ for egg yolk, liver, adipose tissue and longissimus dorsi muscle of the vitamin E supplemented groups, respectively. The results showed that meat, with the exception of chicken thigh, is not an important supplier of vitamin E, not even from animals fed a vitamin E enriched diet. Egg yolk became a good source of vitamin E for human nutrition by dietary modification.
    Notes: Zusammenfassung In der vorliegenden Studie wurde der α-Tocopherolgehalt verschiedener Fleischstücke untersucht. Hähnchenschenkel hatte den höchsten α-Tocopherolgehalt, gefolgt von Hähnchenbrust und Schweineschulter (p〈0.05). Die niedrigsten Konzentrationen wurden im Musculus longissimus dorsi vom Schwein, Rind, Kalb und in der Rindsschulter nachgewiesen. Mit dem durchschnittlichen, täglichen Verzehr an magerem Fleisch (105 g) in der Schweiz wurden die Empfehlungen für die tägliche Vitamin E-Zufuhr zu 3 % gedeckt. Die Supplementierung des Schweine- und Legehennenfutters mit 200 mg α-Tocopherolacetat/kg führte zu einem signifikanten Anstieg des α-Tocopherolgehaltes in allen untersuchten Produkten. Die α-Tocopherolakkumulierung unterschied sich gemäß folgender Rangordnung: Eigelb 〉 Leber 〉 Fettgewebe 〉Musculus longissimus dorsi. Die Nährstoffdichten betrugen 28.8, 7.3, 0.9 und 1.2 mg α-Tocopherol/MJ für Eigelb, Leber, Fettgewebe und Musculus longissimus dorsi der jeweiligen mit Vitamin E supplementierten Gruppe. Diese Ergebnisse zeigen, daß Fleisch, mit Ausnahme des Hähnchenschenkels, von Tieren mit supplementierten Diäten kein bedeutender Vitamin E-Lieferant ist. Hingegen wurde Eigelb durch fütterungsbedingte Modifikation zu einer guten Vitamin E-Quelle.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nutrition 38 (1999), S. 1-13 
    ISSN: 1436-6215
    Keywords: Key words Pharmacotherapy – obesity – appetite suppressant – thermogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary Many new substances are currently being investigated for their usefulness in the pharmacotherapy of obesity. Most drugs interfere with monoamine neurotransmitter (serotonin, noradrenalin, dopamine and histamine) effects and act as an appetite suppressant. Other approaches are to primarily increase thermogenesis (e.g. β3-adrenoceptor agonists), or to decrease fat absorption by inhibiting the pancreatic lipase (orlistat). New promising agents are substances that increase the effect of corticotropin releasing factor (CRF) or urocortin in the brain (CRF-binding protein ligand inhibitor) and a neuropeptide Y (NPY) Y5 receptor antagonist. The clinical relevance of leptin in the therapy of obesity is probably limited, but can not be fully evaluated at the moment. As obesity has a multifactorial basis, all these substances have in common the fact that they can not cure obesity. They should only be used as an adjunct to classical strategies like diet and exercise in severe obesity. For developing new, perhaps even more specific pharmacological agents, further research is needed to understand the individually different genetic and physiological basis of obesity.
    Type of Medium: Electronic Resource
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