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  • 1
    Electronic Resource
    Electronic Resource
    Simple Preparation of Diethyldithiocarbamic Acid Selenotrisulfide (1995)
    Springer
    Naturwissenschaften 82 (1995), S. 476-477 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01131600
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  • 2
    Electronic Resource
    Electronic Resource
    Simple preparation of diethyldithiocarbamic acid selenotrisulfide (1995)
    Springer
    Naturwissenschaften 82 (1995), S. 476-477 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01131600
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  • 3
    Electronic Resource
    Electronic Resource
    Heats of Fusion and Transformation for Some Metals and Compounds. (1966)
    s.l. : American Chemical Society
    Journal of chemical & engineering data 11 (1966), S. 571-574 
    Details
    ISSN: 1520-5134
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/je60031a031
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  • 4
    Electronic Resource
    Electronic Resource
    Vesicle propulsion in haptotaxis: A local model (2000)
    Springer
    The European physical journal 3 (2000), S. 403-412 
    Details
    ISSN: 1292-895X
    Keywords: PACS. 87.16.-b Subcellular structure and processes [:AND:] 87.19.-j Properties of higher organisms - 47.55.Dz Drops and bubbles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: We study theoretically vesicle locomotion due to haptotaxis. Haptotaxis is referred to motion induced by an adhesion gradient on a substrate. The problem is solved within a local approximation where a Rayleigh-type dissipation is adopted. The dynamical model is akin to the Rousse model for polymers. An invariant formulation is used to solve a dynamical model which includes a kind of dissipation due to bond breaking/restoring with the substrate. For a stationary situation where the vesicle acquires a constant drift velocity, we formulate the propulsion problem in terms of a nonlinear eigenvalue (the a priori unknown drift velocity) one of Barenblat-Zeldovitch type. A counting argument shows that the velocity belongs to a discrete set. For a relatively tense vesicle, we provide an analytical expression for the drift velocity as a function of relevant parameters. We find good agreement with the full numerical solution. Despite the oversimplification of the model it allows the identification of a relevant quantity, namely the adhesion length, which turns out to be crucial also in the nonlocal model in the presence of hydrodynamics, a situation on which we have recently reported (I. Cantat and C. Misbah, Phys. Rev. Lett. 83, 235 (1999)) and which constitutes the subject of a forthcoming extensive study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101890070011
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  • 5
    Electronic Resource
    Electronic Resource
    Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases (2000)
    Springer
    Cellular and molecular life sciences 57 (2000), S. 738-746 
    Details
    ISSN: 1420-9071
    Keywords: Key words.klotho; endothelial function; nitric oxide production; hypertension; renal failure; cytokine.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. The human aging process is associated with vascular endothelial dysfunction. However, humoral factors which might protect against endothelial dysfucntion during aging have not yet been identified. We recently identified the klotho gene as a possible regulator of human aging. In the present study using the klotho-deficient heterozygous mouse, we examined whether the Klotho protein is a humoral factor protecting against endothelial dysfunction. We further cloned rat klotho cDNA and investigated whether klotho mRNA expression in rat kidney is altered under pathological conditions such as hypertension, hyperlipidemia, renal failure, and inflammatory stress. The Klotho protein itself, or its metabolites, promotes endothelial NO production in aorta as well as arterioles, and klotho mRNA in kidney is downregulated under sustained circulatory stress.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000180050038
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  • 6
    Electronic Resource
    Electronic Resource
    A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro (1998)
    Springer
    Diabetologia 41 (1998), S. 1024-1028 
    Details
    ISSN: 1432-0428
    Keywords: Keywords CD38 gene ; susceptibility ; missense mutation ; Type II diabetes mellitus ; cyclic ADP-ribose ; ADP-ribosyl cyclase ; cyclic ADP-ribose hydrolase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cyclic adenosine 5′diphosphate-ribose (cADPR) is thought to have a second messenger role in insulin secretion through mobilisation of Ca2 +. As human lymphocyte antigen CD38 has both ADP-ribosyl cyclase and cADPR hydrolase activity, it may be important in glucose-induced insulin secretion in islets. Thirty one randomly selected Japanese patients with Type II diabetes mellitus who had first-degree and/or second-degree relative(s) with Type II diabetes mellitus were screened for mutations of this gene using single-stranded conformation polymorphism. Two variant patterns in exon 3 and exon 4 of the CD38 gene were identified. The variant in exon 3 resulted in an amino acid substitution from Arg140 (CGG) to Trp (TGG). The Arg140Trp mutation was observed in 4 of 31 patients, and allele frequencies were significantly different in patients and the control subjects (p = 0.004). One patient with this mutation has two missense mutations on beta cell/liver glucose transporter (GLUT2) gene; her mother, who has impaired glucose tolerance, also has this mutation on the CD38 gene and one missense mutation on the GLUT2 gene. Enzyme activity studies using COS-7 cells expressing the Arg140Trp mutation showed a reduction in ADP-ribosyl cyclase and cADPR hydrolase activity of around 50 %. The Arg140Trp mutation on CD38 thus appears to contribute to the development of Type II diabetes mellitus via the impairment of glucose-induced insulin secretion in the presence of other genetic defects. [Diabetologia (1998) 41: 1024–1028]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051026
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  • 7
    Electronic Resource
    Electronic Resource
    5′-flanking DNA of the human insulin receptor gene and long terminal repeat of mouse mammary tumour virus bind to the same nuclear protein(s) (1989)
    Springer
    Diabetologia 32 (1989), S. 877-880 
    Details
    ISSN: 1432-0428
    Keywords: Insulin receptor ; glucocorticoid responsive element ; gel mobility shift analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The interaction of nuclear protein extracted from rat liver and 5′-flanking DNA of the human insulin receptor gene was investigated with the aid of gel mobility shift analysis. When 5′-flanking DNA (-1255/-1206 or -385/-345 base pairs) was incubated with nuclear protein, two or three 32P-DNA species (protein binding DNA fragment(s) and free DNA fragment) were detected. These bands did not disappear in spite of increasing amounts of synthetic poly(dI-dC), showing that nuclear protein binds specifically to 5′-flanking DNA of the insulin receptor gene. Increasing amounts of long terminal repeat of mouse mammary tumour virus resulted in a reciprocal decrease in nuclear protein binding to 5′-flanking DNA of insulin receptor gene. These results suggest that 5′-flanking DNA of insulin receptor gene binds to the same nuclear protein to which long terminal repeat of mouse mammary tumour binds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00297453
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  • 8
    Electronic Resource
    Electronic Resource
    Transforming growth factor-β receptor and fibronectin expressions in aortic smooth muscle cells in diabetic rats (1997)
    Springer
    Diabetologia 40 (1997), S. 383-391 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Transforming growth factor-β (TGF-β) ; TGF-β receptor ; fibronectin ; aortic smooth muscle cells ; diabetes mellitus ; smooth muscle cell phenotype.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Smooth muscle cells in arteries of diabetic rats and rabbits have unique properties including the overexpression of platelet-derived growth factor (PDGF) β-receptor compared with controls. Fibronectin, one of the increased components of extracellular matrices in diabetic arteries, plays an important role in the phenotypic change of smooth muscle cells from the contractile to the synthetic type with the expression of the PDGF β-receptor. Moreover, fibronectin synthesis is regulated by transforming growth factor-β (TGF-β). In this study, we report on the expression of TGF-β receptors in diabetic smooth muscle cells, by immunohistochemistry, cross-linking of 125I-TGF-β1 to cells and quantitative reverse transcription-polymerase chain reaction. We also report on the effects of TGF-β1 on fibronectin synthesis of diabetic smooth muscle cells by use of ELISA and immunoprecipitation, in order to clarify the role of TGF-β-fibronectin pathway in forming characteristic changes of diabetic smooth muscle cells. Cultured aortic smooth muscle cells of diabetic rats expressed TGF-β type II receptor about 8.7 times that of controls at the protein level and 5.7 times at the mRNA level, whereas the expression of the type I receptor did not differ between the two types of smooth muscle cells. These changes were accompanied by increased fibronectin synthesis in diabetic smooth muscle cells in response to TGF-β1. Furthermore, protein expression of fibronectin, and mRNA and protein of TGF-β type II receptor were increased in the diabetic aorta compared with the control aorta in vivo, implying the importance of the TGF-β-fibronectin pathway for the unique biology of smooth muscle cells in the diabetic artery. [Diabetologia (1997) 40: 383–391]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050691
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  • 9
    Electronic Resource
    Electronic Resource
    Expression of MyoD and myogenin in dystrophic mice, mdx and dy, during regeneration (2000)
    Springer
    Acta neuropathologica 99 (2000), S. 619-627 
    Details
    ISSN: 1432-0533
    Keywords: Key words MyoD ; Myogenin ; Muscle regeneration ; dy mouse ; mdx mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Expression of two myogenic regulatory factors, MyoD and myogenin, was studied in regenerating muscles of dystrophic mice and compared to a chemically induced regeneration process. First, the distribution of the two proteins was determined immunohistochemically at various time points after single administrations of a local anaesthetic, bupivacaine hydrochloride, which causes myonecrosis followed by regeneration. Detectable levels of MyoD appeared at 18 h and the expression reached their maximum levels at 48 h after the injection, which coincide with the stage when satellite cells are activated and start to proliferate. Myogenin became detectable in 24 h and its expression reached its highest level at 72 h after injection when newly formed myotubes appeared. The two genes were also expressed in the dystrophic muscles from dy and mdx mice which exhibit dystrophic pathological features but are associated with different phenotypes. In mdx mice the two genes were expressed at reasonably high levels in parallel with the active regenerating process, whereas in dy mice MyoD and myogenin expressions decreased as fibrosis progressed. However, MyoD was relatively more strongly expressed in the larger mature myotubes of dy mice than in those of mdx mice, suggesting prolonged regenerative activity. In dy and mdx mice, MyoD and myogenin were expressed in different quantities, indicating that these animals have distinct regenerating activities. Our findings confirm that expression of both MyoD and myogenin genes is necessary in the regenerative process for the proliferation of satellite cells (myoblasts) and for the development of early regenerating fibers (myotubes) even in dystrophic muscles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010051172
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  • 10
    Electronic Resource
    Electronic Resource
    Initiation of satellite cell replication in bupivacaine-induced myonecrosis (1994)
    Springer
    Acta neuropathologica 88 (1994), S. 252-257 
    Details
    ISSN: 1432-0533
    Keywords: Key words Satellite cell ; Satellite cell replication ; Regeneration ; Bupivacaine ; Bromodeoxyuridine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To determine how and when the satellite cells are stimulated to replicate in muscle regeneration, the rat soleus muscle was examined chronologically after bupivacaine-induced myonecrosis. Bromodeoxyuridine and desmin-positive mononuclear cells, indicating the start of satellite cell replication, were seen 25 h after bupivacaine treatment when macrophages had already invaded the sarcoplasm of necrotic fiber. These findings suggest that muscle regeneration starts as early as the time at which macrophages begin to scavenge necrotic material. Proliferating myoblasts increased in number, reaching a maximum at 49 h after myonecrosis, and decreased in number 3 days after the myoblasts fused with each other to form myotubes. The satellite cell proliferation after bupivacaine-induced myonecrosis began at almost the same time as in crush injury, and earlier than after muscle transplantation using whole intact or minced muscle fragments. The earlier begining and more rapid regenerating process probably resulted from the preservation of intact satellite cells, blood vessels and peripheral nerves in the bupivacaine-induced myonecrosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293401
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