ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The complex alkylation reactions of leucoflavin derivatives are shown to give O-substituted products of a new type rather than N-substituted ones. Characteristic differences in the chemical behaviour of (iso)alloxazines and of their leuco-compounds are outlined. Stabilization and decomposition of flavosemiquinones have been further studied. It is shown, that flavin catabolism (N-10-dealkylation) occurs in the semiquinonoid state at room temperature, and is neither confined to hydroxyalkylflavins, nor to specific catalysis by light. Based upon these and recent findings of other authors, a new mechanism of metal-catalysed flavin catabolism is proposed. 1,3,10-Trimethyl-leucoflavin was prepared and found to give a stabilized monomeric semiquinone on oxidation.
Additional Material:
7 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19600430149
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