Digitale Medien
Springer
Naunyn-Schmiedeberg's archives of pharmacology
286 (1974), S. 195-210
ISSN:
1432-1912
Schlagwort(e):
Cats
;
Cardiac Glycosides
;
Inotropic Action
;
Distribution
;
Protein Binding
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary The tissue distribution and the positive inotropic effect of α- and β-methyl-digoxin, digoxin, and digitoxin were investigated in cats under pentobarbital anaesthesia, the emetic effect of β-methyl-digoxin and digoxin in unanaesthetized animals. 1. The distribution volume calculated by dividing the injected dose by the concentration in the plasma water after 60 min decreased in the order digitoxin 〉 β-methyl-digoxin ≥ α-methyl-digoxin 〉 digoxin. 2. The distribution coefficients between tissue and plasma water decreased for all glycosides in the order kidney 〉 liver 〉 heart 〉 diaphragm 〉 erythrocytes 〉 perirenal fat 〉 brain. 3. α-Methyl-digoxin and digoxin were metabolized to a larger extent than were β-methyl-digoxin and digitoxin. 4. 200 nmoles/kg digoxin produced arrhythmias, whereas equimolar doses of the other glycosides were well tolerated. 5. Except for α-methyl-digoxin, there was a close relation between the increase in dp/dt max and the concentration in the plasma water 60 min after the injection. The differences in the equieffective doses of β-methyl-digoxin, digoxin, and digitoxin can therefore be explained by the differences in tissue distribution. 6. Although higher concentrations of β-methyl-digoxin than of digoxin were found in the brain, there was no difference in the central activity of the two glycosides.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00501612
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