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  • 1985-1989
  • 1975-1979  (4)
  • 1976  (4)
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  • 1985-1989
  • 1975-1979  (4)
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  • 1
    Electronic Resource
    Electronic Resource
    PLASMA PROPRANOLOL CONCENTRATION IN PATIENTS WITH ANGINA AND ACUTE MYOCARDIAL INFARCTION (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 3 (1976), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Plasma levels of propranolol were measured fluorometrically in patients with angina pectoris and in patients admitted to the Coronary Care Unit with acute myocardial infarction.2. In thirty patients with stable angina pectoris, plasma propranolol levels varied almost linearly with doses between 10 and 120 mg during 6-hourly chronic oral administration. Plasma levels greater than 100 ng/ml produced 70–80% reduction in the tachycardia induced by strenous exercise on a treadmill.3. In nineteen patients with acute myocardial infarction given oral propranolol, 20 mg 6-hourly, peak as well as trough plasma levels of the drug increased progressively but remained below 100 ng/ml in all except two patients during the first 24 h after their admission to the Coronary Care Unit.4. The data suggest that the use of low and fixed doses of propranolol may not produce adequate plasma levels or significant β-adrenoceptor blockade in the early stages of acute myocardial infarction in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1976.tb00606.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    EFFECTS OF AMIODARONE AND L8040, NOVEL ANTIANGINAL AND ANTIARRHYTHIC DRUGS, ON CARDIAC AND CORONARY HAEMODYNAMICS AND ON CARDIAC INTRACELLULAR POTENTIALS (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 3 (1976), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effects on the coronary and systemic haemodynamics of intravenous and intracoronary injections of two benzfuran derivatives, amiodarone and its brominated analogue (L8040), were studied in open-chest anaesthetized dogs. The effects of L8040 on cardiac intracellular potentials after 6 weeks of 20 mg/kg intraperitoneal injections in rabbits were also investigated.2. Both compounds produced dose-related and quantitatively similar decreases in coronary vascular resistance following their intracoronary administration; threshold effects occurred with about 0.25 mg of each drug and maximal effects with 4 mg. Larger intracoronary doses produced measurable systemic effects.3. Intravenous injections of amiodarone and L8040 (2·5·10 mg/kg) produced dose-related decreases in heart rate and aortic pressure with a fall in total peripheral resistance. The left ventricular output was either unaffected or increased with a consistent augmentation in stroke volume.4. The bradycardia produced by both drugs was associated with prolongation of the P–R interval of the electrocardiogram with no significant effect on the QRS duration or the Q–T interval.5. Each drug produced a decrease in the total peripheral vascular resistance with no change in left ventricular end diastolic pressure except after 10 mg/kg doses which led to an increase in this parameter.6. Cardiac contractile force and peak LV dp/dt were reduced by both drugs in a dose-related manner.7. Chronic intraperitoneal administration of L8040 in rabbits caused a prolongation of the duration of the atrial and ventricular intracellular potential without an effect on the maximal rate of depolarization.8. The effects of amiodarone or L8040 on the coronary circulation and arterial pressure may be attributed to their vasodilator properties but their depressant actions on cardiac contractile force and peak LV dp/dt with an increase in left ventricular end diastolic pressure at high doses, also suggest intrinsic negative inotropic propensity for both compounds.9. It is concluded that the overall effects on coronary and systemic haemodynamics of amiodarone and its brominated analogue are likely to permit a favourable influence on the balance of oxygen supply and demand in myocardial ischaemia; in addition, their actions on sinoatrial and atrio-ventricular conduction as well as those on cardiac repolarization suggest potential antiarrhythmic properties which merit investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1976.tb00620.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    DIFFERENTIAL LABELING OF JUVENILES A Multivariate Analysis (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Criminology 13 (1976), S. 0 
    Details
    ISSN: 1745-9125
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Law
    Notes: Prior studies and commonsense definitions of the decision-making process suggest that the ascriptive power of the commitment offense, gravity of the commitment offense, psychiatric characteristics of the offender, and the social identity given off by the offender's family would be causally related to variance in the deviance label, i.e., decisions to commit to a mental hospital rather than to a corrections institution. Case records from both settings were analyzed for traces of the decision. However, controlling for each of the alternative variables fails to eliminate the strong relationship between intensity of the offender's prior career of delinquent behavior and the formal deviance label qua type of commitment. The multivariate path model suggests that delinquency intensity and type of commitment are the two most important determinants of mental classification.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1745-9125.1976.tb00681.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Nitrate reductase and its relationship to protein and yield characteristic of triticale (1976)
    Springer
    Euphytica 25 (1976), S. 193-199 
    Details
    ISSN: 1573-5060
    Keywords: Triticale ; nitrate reductase activity ; correlation with protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary The optimum conditions for extraction and assay for nitrate reductase (NRase) activity in triticale were determined. NRase activity was positively correlated with plant height, grain yield and grain protein. The leaf protein, seed set or kernel weight had no significant correlation with the NRase activity. Data indicated an apparent interrelationship between NRase activity, grain protein, plant height and grain yield.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00041545
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    Paper (German National Licenses)
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