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  • 1980-1984  (2)
  • 1981  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 20 (1981), S. 268-273 
    ISSN: 1432-0428
    Keywords: Central nervous system ; CNS peptides ; insulin receptors ; insulin ; experimental diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary While insulin effects on the central nervous system (CNS) mediated through hypoglycaemia are well known, direct insulin effects on the CNS remain controversial. Recently, we found insulin receptors in all areas of the rat brain, with highest concentrations in the olfactory bulb, cerebral cortex and hypothalamus; all areas involved in feeding. Insulin receptors in brain were, by multiple criteria, similar to insulin receptors on classical target tissues for insulin, such as liver and fat. Insulin itself has been identified in the rat brain at concentrations on average ten times higher than in plasma. Highest concentrations were found in the olfactory bulb and hypothalamus. Brain insulin was indistinguishable from purified insulin by its behaviour in the radioimmunoassay, radioreceptor assay, bioassay and gel chromatography. In two experimental models representing extremes of plasma insulin concentrations (obese hyperinsulinaemic mice and diabetic insulinopenic rats) there were no significant changes in the concentration of insulin receptors in brain while liver receptors were modified in the expected way. This may reflect the protective influence of the blood-brain barrier or some special quality of brain insulin receptors. Insulin concentrations in brain were also unchanged in both models, which is probably indicative of the local synthesis of insulin. The role of insulin in the CNS is unknown. Besides well known metabolic actions of insulin, new roles can be postulated such as neurotransmission, neuromodulation and paracrine signalling.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of fusion energy 1 (1981), S. 117-127 
    ISSN: 1572-9591
    Keywords: Advanced fuels ; wall loading ; plasma reactivity ; high beta
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract This paper investigates the effect of wall loading limitations and choice of plasma stability index beta on the feasibility of advanced fuel fusion reactors. Two new conceptual tools are introduced to facilitate this analysis: the “effective reactivity,” which includes all of the reaction-relevant parameters that determine the fusion power density, and the “critical radius,” which is the maximum allowable minor radius of a fusion reactor, beyond which the power generated in the plasma will exceed allowable loadings of radiant energy or neutrons on the first wall. It is shown that if high beta (greater than 0.2) fusion reactors are feasible, the high reactivity of the DT reaction cannot be fully exploited because of wall loading limitations. In addition, some high beta reactors with advanced fuels are also found to be wall loading limited, and to have excess reactivity, which can be traded off for lower magnetic fields, longer particle containment times, etc. Under certain circumstances, the reduced materials problems associated with some advanced fuels may outweigh the reactivity advantage of the DT reaction, and make one of them the reaction of choice for high beta fusion reactors.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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