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  • 1980-1984  (3)
  • 1965-1969
  • 1982  (3)
  • 1
    ISSN: 1432-1041
    Keywords: acetylsalicylic acid ; salicylic acid ; effervescent tablets ; enteric coated tablets ; liquid chromatography ; platelet aggregation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Single doses of effervescent tablets (1200 mg) and enteric coated (EC) tablets (1300 mg and 650 mg) of acetylsalicylic acid (aspirin, ASA) were given to healthy volunteers in random order. Plasma ASA and salicylic acid (SA) levels were measured and concurrent in vitro measurements of the volunteers' platelet aggregation were carried out. The effervescent preparation resulted in peak ASA concentrations of 17–40 mg/l, achieved 20 to 30 min after a 1200 mg dose, whereas peak ASA levels of 0.01–0.37 mg/l were observed 4–6 h after a 650 mg dose of the EC preparation. With all the aggregating agents that were added to the test system maximum inhibition of platelet aggregation (about 50% of pre dose levels) was seen 1.0 h after the effervescent ASA dose, and persisted to at least 24 h, but with the EC preparation not until 24 h, at which time the degree of inhibition was also about 50% of pre-dose levels. A 1.0 g dose of sodium salicylate had no effect on in vitro platelet function. It was concluded that mean plasma levels of ASA of less than 0.25 mg/l are sufficient to depress aggregation by approximately 50%. A low dose of ASA taken daily either as effervescent ASA or EC ASA, significantly inhibits platelet aggregation and so may reduce the risk of ischaemic episodes in susceptible patients.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The results of an experiment to study elasticK + K − photoproduction are presented. Differential cross sections and spin density matrix elements for ϕ(1.019) production are stddied as a function of incident photon energy and over a wide range of momentum transfer,t (t min 〉t〉−1.5(GeV/c)2). Helicity conserving amplitudes are observed to dominate ϕ production throughout this range and the differential cross sections exhibit a forward diffractive peak which cannot be understood in terms of a simple exponential dependence. A new value of the photon ϕ coupling constant is determined and shown to be consistent withe + e − annihilation measurements. A detailed study of the energy dependence of the differential cross sections is made, including other experimental data, and the extracted effective Regge trajectory compared with other diffractive processes. A study of the dependence of theK + K − decay angular distribution on invariant mass reveals evidence for ans wave contribution interfering with thep wave ϕ which may be attributable to theS * meson.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 28 (1982), S. 616-625 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A multiparameter corresponding-states correlation has been developed to describe fossil-fluid thermodynamic properties needed to design fluid-flow, heat-exchange, and other unit operations in coal-liquefaction plants. Three equation-of-state parameters, a molecular-size/separation parameter, a molecular-energy parameter, and a molecular-orientation parameter are used to characterize nonpolar and slightly polar aromatic hydrocarbons. A conformal-solution model is developed for predicting thermodynamic properties of coal-derived mixtures.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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