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  • 2005-2009
  • 1980-1984  (3)
  • 1984  (3)
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Material
Years
  • 2005-2009
  • 1980-1984  (3)
Year
  • 1
    Electronic Resource
    Electronic Resource
    High melanosome engulfing activity of cutaneous fibroblasts in macular amyloidosis: an electron microscopic study (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 11 (1984), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Six patients with macular amyloidosis were investigated by electron microscopy and various morphological changes in fibroblasts were identified. Many cells, which seemed to be macrophages by light microscopy, proved to be fibroblasts. The digesting action of fibroblasts was well developed and many melanosomes were taken into the cells making the cells resemble melanophages. The fibroblasts extended long, thin and branched cytoplasmic processes to surround the amyloid mass, and the cells selectively extended these into the narrow spaces between collagen and amyloid. The fibroblast showed highly developed endocytotic activity and probable ingcstion of amyloid by pinocytosis or phagocytosis. The developed rough cndoplasmic reticulum contained much protein and was active in secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1984.tb00406.x
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    The use of improved ruthenium red staining for the ultrastructural detection of proteoglycan aggregates in normal skin and Lichen myxoedematosus (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 11 (1984), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Improved ruthenium red staining has been applied to normal human skin and lichen myxoedematosus skin lesions for the detection of the fine structure proteoglycan aggregates. In 4 samples of normal skin and in a patient with lichen myxoedematosus, the typical fine ultrastructures of proteoglycan aggregates, i.e., many short irregularly-curled filaments of varying lengths attached to long and rather straight filaments of hyaluronic acid were shown. Although lichen myxoedematosus is thought o be due to the faulty formation of proteoglycan aggregates, we suggest a different view, that this improved method of ruthenium red staining is useful for the detection of proteoglycan aggregates, and provides a better preparation for electron microscopy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1984.tb00380.x
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    An ultrastructural study of pretibial myxedema utilizing improved ruthenium red stain (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 11 (1984), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A case of pretibial myxedema associated with Graves' diseases has been studied by electron microscopy utilizing an improved ruthenium red stain. An organized network of microfibrils with knobs were found within the widened interfibrous spaces. This network was clearly demonstrated by the ruthenium red stain, but only a weak trace could be observed when conventional staining techniques were utilized. Knobs of the network seemed to be composed of ruthenium red-positive granules which surrounded normal fibers and granules of degrading collagen fibers. Many fibroblasts showed dilated rough endoplasmic reticulum containing much amorphous material which indicated a significant role of fibroblasts in the pathogenesis of this disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1984.tb00362.x
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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