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  • 1
    Electronic Resource
    Electronic Resource
    Structural selectivity of topological indexes in alkane series (1985)
    s.l. : American Chemical Society
    Journal of chemical information and modeling 25 (1985), S. 23-27 
    Details
    ISSN: 1520-5142
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ci00045a006
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cooperativity of tetrodotoxin action in the frog node of Ranvier (1985)
    Springer
    Pflügers Archiv 405 (1985), S. 237-243 
    Details
    ISSN: 1432-2013
    Keywords: Node of Ranvier ; Na channels ; Tetrodotoxin ; Cooperativity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 1. The steady state effects and rates of action of tetrodotoxin (TTX) on sodium current were studied in the voltage clamped frog node of Ranvier. 2. Inactivation of the sodium current was separated into fast and slow phases. Both phases were assumed to correspond to two different currents (fast and slow) flowing through fast and slow channels (Benoit et al. 1985). 3. The dose-response curve of the steady state effect of tetrodotoxin on the fast current was sigmoid. An analysis of this effect in double logarithmic coordinates gave a Hill coefficient of 1.74. 4. The rates of tetrodotoxin action on the fast current were determined by the reversible reduction of the peak current recorded at a potential (+20 mV) at which the slow current was relatively small. 5. After an initial delay, the onset of TTX effect followed an exponential function of time whose constant decreased with increasing tetrodotoxin concentrations. Expressed as the time corresponding to a reduction of 2% of the current, the delay (δt2%) increased from about 100 ms with 300 nM-TTX to about 30 s with 1 nM-TTX. 6. When tetrodotoxin was removed, the offset developed quasi-instantaneously and followed an exponential function of time whose constant was independent of the toxin concentration. 7. Both steady state and rates of tetrodotoxin effects could be fitted well if one assumed that the block of one fast channel occurred after binding of two TTX molecules to two cooperative sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00582567
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Chemical ideograms and molecular computer graphics (1985)
    Springer
    The visual computer 1 (1985), S. 49-63 
    Details
    ISSN: 1432-2315
    Keywords: Molecular modelling ; Computer-assisted drug design (CADD) ; Graphics language ; Molecular computer graphics (MCG) ; Chemical information systems
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract Molecular computer graphics (MCG) has become the indispensable complement of experimental chemical and biological tools and, in a way, will shape the evolution of these fields. This accelerated and popularized evolution takes root in the visual, even scenic, grasping of fundamental chemical concepts, perceived as veritable ideograms, which condense a vast amount of information with a few two- or threedimensional graphic symbols. With MCG one can carry out real computerized syntheses of chemical images. MCG is also an ideal tool through which to visualize the changes of a system as a function of time. This review article describes the potentials and advantages of structural MCG for visualizing the basic steps of important modelization concepts, particularly for handling on-line structures in information networks and in computer-assisted drug design (CADD) applications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01901269
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Radiation necrosis of the brain: Time of onset and incidence related to total dose and fractionation of radiation (1985)
    Springer
    Neuroradiology 27 (1985), S. 44-47 
    Details
    ISSN: 1432-1920
    Keywords: Radiation therapy ; radiation injuries ; radiation dose-interval of onset ; incidence ; brain tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Clinical deterioration during or after brain irradiation may be due to progression of neoplasm or radiation induced necrosis of the neoplasm and/or of normal brain tissues, or a combination of all. Eight patients with histologically documented radiation induced lesions of the brain are included in this study. The radiation therapy included the fractional schedule, group A, who received 280 to 300 rads daily, to a total dose of 4500 to 5000 rads and weekly exposure did not exceed 900 rads. Group B patients were exposed to 850 rads, daily dose on day 1, 3, 21 and 23 to a total dose of 3400 rads. The incidence of radiation induced lesions of brain was 3.4% in patients group A and 8.7% in group B patients (without) statistical significance). The median time of onset of these lesions after completion of radiation therapy was significantly shorter in group B patients (8.5 months) as opposed to group A patients (21 months).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00342516
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Chiral liquid crystalline side chain polymers (1985)
    Springer
    Polymer bulletin 14 (1985), S. 179-186 
    Details
    ISSN: 1436-2449
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary Optically active liquid crystalline side chain polymers with dif ferent flexible spacer groups (n=2–11) and different main chains (acry lates, methacrylates and α chloroacrylates) are described. (+)-2-methyl butyloxyphenyl esters of benzoic acid were chosen as the mesogenic group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00708478
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Thermotropic liquid crystalline polymers smectic “C” phase in a liquid side-chain poly α chloroacrylate (1985)
    Springer
    Polymer bulletin 14 (1985), S. 549-556 
    Details
    ISSN: 1436-2449
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary Microscopic observations, thermal studies, dielectric relaxation measurements and X-Ray diffraction experiments on magnetically aligned samples of a mesogenic side-chain poly 4 —butoxy-phenyl —4 (α chloroacryloyloxyhexyloxy) benzoate are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00271614
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    Paper (German National Licenses)
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