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Digitale Medien

Nephrotoxicity of lomustine (1985)

Ellis, Mark E. ; Weiss, Raymond B. ; Kuperminc, Mario

Springer

Cancer chemotherapy and pharmacology 15 (1985), S. 174-175

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ISSN: 1432-0843

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary A patient is presented who developed nephrotoxicity after therapy with lomustine (CCNU) for astrocytoma of the brain. Only three other cases of lomustine nephrotoxicity have been reported, and all cases have been associated with cumulative drug doses of greater than 1,500 mg/m2. The clinical and pathologic features of lomustine nephrotoxicity are reviewed. It is recommended that cumulative doses of more than 1,200–1,400 mg/m2 lomustine be avoided because of the risk of nephrotoxicity.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00257532

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