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  • 1985-1989  (8)
  • 1985  (8)
  • 1
    Electronic Resource
    Electronic Resource
    The acute changes in serum binding of disopyramide and flecainide after myocardial infarction (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 253-255 
    Details
    ISSN: 1432-1041
    Keywords: disopyramide ; flecainide ; myocardial infarction ; drug plasma binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In the serum basic drugs are principally bound to alpha1-acid glycoprotein (AAG). Following acute myocardial infarction it has been shown that the levels of AAG rise. The serum levels of total protein, albumin, AAG and the protein binding of 2 antiarrhythmic drugs which are bases, disopyramide and flecainide, was measured in vitro with blood samples from eleven patients taken over the first 5 days following myocardial infarction. Mean AAG levels significantly increased from 1.04 g/l on Day 1 to 1.80 g/l on Day 5. The binding of disopyramide, which is highly bound, rose from 80% to 87%, representing a 35% decrease in free drug concentration. In contrast the binding of flecainide fell from 61% to 53%, a 20% increase in free drug concentration. These data suggest that although the binding of strongly bound drugs responds appropriately to increases in binding protein after acute myocardial infarction, poorly bound drugs are displaced from binding sites possibly by endogenous substances. Since the pharmacological effects of a drug are related to its free (unbound) concentration, the changes in the proportions of free to bound drug after myocardial infarction may have important clinical implications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543319
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The relationship between clearance of theophylline and age within the adult age range (1985)
    Springer
    European journal of clinical pharmacology 29 (1985), S. 177-179 
    Details
    ISSN: 1432-1041
    Keywords: theophylline clearance ; age ; adult age range ; normal subjects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Twenty volunteers aged between 20 and 57 years were given 197 mg of theophylline (as lysine theophylline) by iv infusion over 5 minutes to test the hypothesis that within the adult age range theophylline clearance declines with age. Samples were assayed for theophylline using the EMIT assay and clearance was determined by standard methods. Clearance values were 0.73 ml/min/kg below age 38 years and 0.75 ml/min/kg at and above age 38 years. Multiple regression analysis using age as a continuous variable showed no relationship between age and clearance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00547418
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    A GREEK GRAFFITO FROM AREZZO (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Oxford journal of archaeology 4 (1985), S. 0 
    Details
    ISSN: 1468-0092
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Archaeology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-0092.1985.tb00236.x
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Uptake of CO2 by aquatic vegetation (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Plant, cell & environment 8 (1985), S. 0 
    Details
    ISSN: 1365-3040
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract Photosynthesis by aquatic plants based on the supply of CO2 from air-equilibrated solutions may be limited by the low diffusion coefficient of CO2 in water. For plants in which the transport of CO2 from the bulk medium is by diffusion, and the initial carboxylation uses RUBISCO, CO2 supply can be increased by growth in habitats with fast water flow over the surface (reducing unstirred layer thickness), or with heterotrophically-augmented CO2 levels, including the direct use of sediment CO2. Many aquatic plants using RUBISCO as their initial carboxylase counter the limitations on CO2 supply via the operation of biophysical CO2 concentrating mechanisms which are based on active transport of HCO−3, CO2 or H+ at the plasmalemma, and use bulk-phase HCO−3 or CO2 as the C source. A final group of aquatic plants use biochemical CO2 concentrating mechanisms based on auxiliary carboxylation by PEPc: C4-like and Crassulacean Acid Metabolism–like processes are involved. These various mechanisms for increasing CO2 supply to RUBISCO also help to offset the low specific reaction rate of aquatic plant RUBISCOs at low [CO2] and low [CO2]: [CO2]. In addition to overcoming restrictions on CO2 supply, the various methods of increasing inorganic C availability may also be important in alleviating shortages of nitrogen or photons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3040.1985.tb01677.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Concentration ofd-propranolol in cervico-vaginal mucus: targeting of a novel spermicide (1985)
    Springer
    Advances in contraception 1 (1985), S. 103-108 
    Details
    ISSN: 1573-7195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé On peut envisager la mise au point de nouveaux contraceptifs administrês par voie orale et qui exercent leurs effets en se concentrant dans la glaire cervico-vaginale. Six femmes volontaires bien portantes ont reçu dud-propranolol par voie orale, à des doses de 80 mg. Des prélèvements de plasma et de glaire cervico-vaginale ont été recueillis avant l'ingestion du médicament et à 6 reprises jusqu'à 24 heures après. On a constaté que led-propranolol se concentrait dans la glaire cervico-vaginale. On n'a observé aucune modification de la pression artérielle, de la fréquence cardiaque ou du débit expiratoire maximum.
    Abstract: Resumen Es posible desarrollar nuevos contraceptivos que puedan ser administrados por boca y vayan a producir efecto después de concentrarse en el moco cervico-vaginal. Se administró por bocad-propanolol en dosis de 80 mg a seis voluntarias sanas. Se obtuvieron muestras de plasma sanguíneo y de moco cervico-vaginal antes y en seis ocasiones hasta 24 horas después de la ingestión de la droga. Eld-propanolol fué concentrado en el moco cervico-vaginal. No se observaron cambios en la presión sanguínea, en el pulso o en el pico de expiración forzada.
    Notes: Abstract It may be possible to develop new contraceptives that can be administered by mouth and will exert their effects after concentration in cervico-vaginal mucus.d-Propanolol was administered in 80 mg doses by mouth to six healthy female volunteers. Samples of blood plasma and cervico-vaginal mucus were obtained before and on six occasions up to 24 hours after drug ingestion.d-Propranolol was concentrated in cervico-vaginal mucus. No changes in blood pressure, pulse, or forced expiratory peak flow (FEPF) were observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01849149
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    psi, a plasmid-linked Rhizobium phaseoli gene that inhibits exopolysaccharide production and which is required for symbiotic nitrogen fixation (1985)
    Springer
    Molecular genetics and genomics 200 (1985), S. 278-282 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A strain of R. phaseoli cured of its symbiotic plasmid, pRP2JI, retained the ability to make exopolysaccharide (EPS). However, a region of pRP2JI, when cloned at an increased copy number in wide host-range vectors and transferred to this and other strains of Rhizobium, inhibited EPS synthesis. The gene responsible was termed psi (polysaccharide inhibition) and was located in a region of the symbiotic plasmid close to nodulation and nitrogen fixation genes. psi is important in the symbiosis since a wild-type strain containing psi cloned on a multicopy plasmid failed to form Phaseolus nodules, and mutant strains containing psi::Tn5 mutations failed to fix nitrogen in Phaseolus nodules. It is proposed that the function of psi may be to repress in the bacteriod the expression of genes such as those for EPS synthesis which are normally expressed in free-living culture.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00425436
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Identification of the host-range DNA which allows Rhizobium leguminosarum strain TOM to nodulate cv. Afghanistan peas (1985)
    Springer
    Molecular genetics and genomics 201 (1985), S. 296-300 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The special ability of Rhizobium leguminosarum strain TOM to nodulate cv. Afghanistan peas had previously been shown to be determined by the symbiotic plasmid, pRL5JI, of this strain. A region of pRL5JI, 2.0 kb in size, was found to confer the ability to nodulate cv. Afghanistan peas when transferred to strains of R. leguminosarum which normally fail to nodulate this host. This region of pRL5JI, responsible for the extension of host-range, was closely linked to, but did not include, the genes required for root hair curling. Although extensive homology has been found between the R. leguminosarum nod genes on pRL5JI and those on the normal symbiotic plasmid pRL1JI, a fragment from the 2.0 kb region involved in nodulation of cv. Afghanistan has been identified, which was not homologous to DNA in strains which do not nodulate cv. Afghanistan.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00425674
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  • 8
    Electronic Resource
    Electronic Resource
    Identification of genes and gene products involved in the nodulation of peas by Rhizobium leguminosarum (1985)
    Springer
    Molecular genetics and genomics 198 (1985), S. 255-262 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Mutant strains of Rhizobium leguminosarum have been isolated in which the transposon Tn5 was inserted into the cloned nodulation genes. The mutant strains were examined for their ability to induce nodules and to induce normal root hair curling on peas. Five distinct classes of nod mutations were identified on the basis of the phenotypes of the various mutant strains, and of the mapped locations of the nod:: Tn5 alleles. Three classes of mutants (I, II and III) were defective in nodulation and two classes (IV and V) were delayed in nodule appearance. Mutations of classes I, II and III types affected root hair curling and a subcloned 6.6 kb fragment of DNA containing this region conferred the ability to induce root hair curling upon a Rhizobium strain deleted of its nod genes. Analysis of protein products formed after in vitro transcription and translation of the plasmid DNA corresponding to the class I, II, III and IV regions indicated that proteins of molecular weights 48,000, 45,000, 36,000 and 34,000 were formed. A comparison of protein products formed by equivalent plasmids carrying nod:: Tn5 alleles indicated that the class I mutations blocked the synthesis of the 45,000 molecular weight peptide and that the two products of molecular weights 36,000 and 34,000 were absent from the class II mutants. It is concluded that at least five nod genes are involved in nodulation and the polypeptide products of some of these genes have been identified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00383003
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    Paper (German National Licenses)
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